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Inverse protein folding, the process of designing sequences that fold into a specific 3D structure, is crucial in bio-engineering and drug discovery. Traditional methods rely on experimentally resolved structures, but these cover only a…

Biomolecules · Quantitative Biology 2023-11-27 Igor Melnyk , Aurelie Lozano , Payel Das , Vijil Chenthamarakshan

Ensemble learning remains a cornerstone of machine learning, with stacking used to integrate predictions from multiple base learners through a meta-model. However, deep stacking remains uncommon due to feature redundancy, complexity, and…

Machine Learning · Computer Science 2026-03-03 Çağatay Demirel

Optimal multi-layer device design requires consideration of fabrication uncertainties associated with inter-layer alignment and conformal layering. We present layer-restricted topology optimization (TO), a novel technique which mitigates…

We develop an improved phase calibration method of a reflective spatial light modulator (SLM) using interferometry by employing novel phase masks. We generate the optimised phase masks by using Iterative Fourier Transform Algorithm (IFTA)…

Optics · Physics 2022-04-26 Amar Deo Chandra , Ayan Banerjee

In modern runtime systems, memory layout calculations are hand-coded in systems languages. Primitives in these languages are not powerful enough to describe a rich set of layouts, leading to reliance on ad-hoc macros, numerous interrelated…

Programming Languages · Computer Science 2019-09-13 Karl Cronburg , Samuel Z. Guyer

This paper aims to enhance the performance of Vehicular Platooning (VP) systems integrated with Wireless Federated Learning (WFL). In highly dynamic environments, vehicular platoons experience frequent communication changes and resource…

Networking and Internet Architecture · Computer Science 2025-07-02 Beining Wu , Jun Huang , Qiang Duan , Liang Dong , Zhipeng Cai

Feature pyramids and iterative refinement have recently led to great progress in optical flow estimation. However, downsampling in feature pyramids can cause blending of foreground objects with the background, which will mislead subsequent…

Computer Vision and Pattern Recognition · Computer Science 2021-07-26 Libo Long , Jochen Lang

With the increasing size of pre-trained language models (PLMs), fine-tuning all the parameters in the model is not efficient, especially when there are a large number of downstream tasks, which incur significant training and storage costs.…

Computation and Language · Computer Science 2023-08-24 Feiyu Zhang , Liangzhi Li , Junhao Chen , Zhouqiang Jiang , Bowen Wang , Yiming Qian

LLM-based recommender systems have made significant progress; however, the deployment cost associated with the large parameter volume of LLMs still hinders their real-world applications. This work explores parameter pruning to improve…

Information Retrieval · Computer Science 2025-07-10 Shanle Zheng , Keqin Bao , Jizhi Zhang , Yang Zhang , Fuli Feng , Xiangnan He

Increasing the degrees of freedom of robotic systems makes them more versatile and flexible. This usually renders the system kinematically redundant: the main manipulation or interaction task does not fully determine its joint maneuvers.…

Robotics · Computer Science 2023-09-08 Alin Albu-Schäffer , Arne Sachtler

This paper presents a learning-based extension to a Circular Field (CF)-based motion planner for efficient, collision-free trajectory generation in cluttered environments. The proposed approach overcomes the limitations of hand-tuned force…

Robotics · Computer Science 2025-11-17 Mateus Salomão , Tianyü Ren , Alexander König

Fine-tuning large language models (LLMs) with parameter-efficient techniques such as LoRA and QLoRA has enabled adaptation of foundation models on modest hardware. Yet the efficiency of such training on consumer-grade GPUs, especially under…

Machine Learning · Computer Science 2025-09-17 MSR Avinash

Low-Rank Adaptation (LoRA) has become a widely adopted technique for fine-tuning large-scale pre-trained models with minimal parameter updates. However, existing methods rely on fixed ranks or focus solely on either rank pruning or…

Machine Learning · Computer Science 2025-04-02 Huandong Chang , Zicheng Ma , Mingyuan Ma , Zhenting Qi , Andrew Sabot , Hong Jiang , H. T. Kung

Low-rank adaptation (LoRA) is a widely used parameter-efficient fine-tuning (PEFT) method that learns weight updates $\Delta W = AB$ for pretrained weights $W$ through low-rank adapters $A$ and $B$. While LoRA ensures hardware efficiency,…

Computer Vision and Pattern Recognition · Computer Science 2025-05-30 Yibo Zhong , Jinman Zhao , Yao Zhou

Motivated by a potential application in economics, we investigate a simple dynamical scheme to produce planted solutions in optimization problems with continuous variables. We consider the perceptron model as a prototypical model. Starting…

Disordered Systems and Neural Networks · Physics 2019-12-05 Dhruv Sharma , Jean-Philippe Bouchaud , Marco Tarzia , Francesco Zamponi

Recent advances in GPU accelerated global and detail placement have reduced the time to solution by an order of magnitude. This advancement allows us to leverage data driven optimization (such as Reinforcement Learning) in an effort to…

Machine Learning · Computer Science 2021-09-07 Robert Kirby , Kolby Nottingham , Rajarshi Roy , Saad Godil , Bryan Catanzaro

In this work, Yoshikawa's manipulability index is used to investigate reinforcement learning (RL) as a framework for morphology optimization in planar robotic manipulators. A 2R manipulator tracking a circular end-effector path is first…

Robotics · Computer Science 2025-11-18 Arvind Kumar Mishra , Sohom Chakrabarty

Surface mount technology (SMT) is an enhanced method in electronic packaging in which electronic components are placed directly on soldered printing circuit board (PCB) and are permanently attached on PCB with the aim of reflow soldering…

Optimization and Control · Mathematics 2020-01-28 Irandokht Parviziomran , Shun Cao , Haeyong Yang , Seungbae Park , Daehan Won

Molecular docking, a technique for predicting ligand binding poses, is crucial in structure-based drug design for understanding protein-ligand interactions. Recent advancements in docking methods, particularly those leveraging geometric…

Biomolecules · Quantitative Biology 2024-10-17 Jiaxian Yan , Zaixi Zhang , Jintao Zhu , Kai Zhang , Jianfeng Pei , Qi Liu

The performance of the code a compiler generates depends on the order in which it applies the optimization passes. Choosing a good order--often referred to as the phase-ordering problem, is an NP-hard problem. As a result, existing…

Distributed, Parallel, and Cluster Computing · Computer Science 2020-03-09 Qijing Huang , Ameer Haj-Ali , William Moses , John Xiang , Ion Stoica , Krste Asanovic , John Wawrzynek