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A widely tested approach to overcoming the diffraction limit in microscopy without disturbing the sample relies on substituting widefield sample illumination with a structured light beam. This gives rise to confocal, image-scanning and…

Optics · Physics 2024-06-03 Alexander Duplinskiy , Jernej Frank , Kaden Bearne , A. I. Lvovsky

Diffraction tomography is a widely used inverse scattering technique for quantitative imaging of weakly scattering media. In its conventional formulation, diffraction tomography assumes monochromatic plane wave illumination. This…

Numerical Analysis · Mathematics 2026-03-11 Peter Elbau , Noemi Naujoks , Otmar Scherzer

We propose a novel technique of microscopy to overcome the effects of both scattering and limitation of the accessible depth due to the objective working distance. By combining Laser Optical Feedback Imaging (LOFI) with Acoustic Photon…

Far-field optical microscopy using focused light is an important tool in a number of scientific disciplines including chemical, (bio)physical and biomedical research, particularly with respect to the study of living cells and organisms.…

Atomically controlled crystal growth of thin films has established foundations of nanotechnology aimed at the development of advanced functional devices. Crystallization under non-equilibrium conditions allows engineering of new materials…

In traditional optical imaging systems, the spatial resolution is limited by the physics of diffraction, which acts as a low-pass filter. The information on sub-wavelength features is carried by evanescent waves, never reaching the camera,…

Optics · Physics 2018-12-13 Oren Solomon , Yonina C. Eldar , Maor Mutzafi , Mordechai Segev

Detection of visual anomalies refers to the problem of finding patterns in different imaging data that do not conform to the expected visual appearance and is a widely studied problem in different domains. Due to the nature of anomaly…

Image and Video Processing · Electrical Eng. & Systems 2021-04-29 Dejan Stepec , Danijel Skocaj

Raman microscopy is a powerful method combining non-invasiveness with no special sample preparation. Because of this remarkable simplicity, it has been widely exploited in many fields, ranging from life and materials sciences, to…

The challenge of imaging low-density objects in an electron microscope without causing beam damage is significant in modern TEM. This is especially true for life science imaging, where the sample, rather than the instrument, still…

Optics · Physics 2025-01-29 Francisco Vega Ibáñez , Jo Verbeeck

We demonstrate numerically the diffraction-free propagation of sub-wavelength sized optical beams through simple elements built of metal-dielectric multilayers. The proposed metamaterial consists of silver and a high refractive index…

Optics · Physics 2011-06-07 R. Kotynski , T. Stefaniuk , A. Pastuszczak

Artificial nanostructures with ultrafine and deep-subwavelength feature sizes have emerged as a paradigm-shifting platform to advanced light field management, becoming a key building block for high-performance integrated optoelectronics and…

Terahertz single-pixel imaging (THz SPI) has garnered widespread attention for its potential to overcome challenges associated with THz focal plane arrays. However, the inherently long wavelength of THz waves limits imaging resolution,…

Image and Video Processing · Electrical Eng. & Systems 2025-08-05 Yongsheng Zhu , Shaojing Liu , Ximiao Wang , Runli Li , Haili Yang , Jiali Wang , Hongjia Zhu , Yanlin Ke , Ningsheng Xu , Huanjun Chen , Shaozhi Deng

Interferometric scattering microscopy has been a very promising technology for highly sensitive label-free imaging of a broad spectrum of biological nanoparticles from proteins to viruses in a high-throughput manner. Although it can reveal…

Optics · Physics 2021-08-11 Celalettin Yurdakul , Haonan Zong , Yeran Bai , Ji-Xin Cheng , M. Selim Unlu

Fluorescence labeling is the standard approach to reveal cellular structures and other subcellular constituents for microscopy images. However, this invasive procedure may perturb or even kill the cells and the procedure itself is highly…

Image and Video Processing · Electrical Eng. & Systems 2024-06-25 Han Liu , Hao Li , Jiacheng Wang , Yubo Fan , Zhoubing Xu , Ipek Oguz

Adaptive optics (AO) has revolutionized imaging in {fields} from astronomy to microscopy by correcting optical aberrations. In label-free microscopes, however, conventional AO faces limitations due to the absence of guidestar and the need…

Single-photon avalanche diode (SPAD) arrays have transformed optical imaging by enabling photon-counting sensitivity, picosecond resolution, and high frame-rate operation. These capabilities, however, have remained confined to the visible…

We demonstrate a compact, cost-effective snapshot spectral imaging system named Aperture Diffraction Imaging Spectrometer (ADIS), which consists only of an imaging lens with an ultra-thin orthogonal aperture mask and a mosaic filter sensor,…

Computer Vision and Pattern Recognition · Computer Science 2023-09-29 Tao Lv , Hao Ye , Quan Yuan , Zhan Shi , Yibo Wang , Shuming Wang , Xun Cao

Hyperspectral optoacoustic microscopy (OAM) enables obtaining images with label-free biomolecular contrast, offering excellent perspectives as a diagnostic tool to assess freshly excised and unprocessed tissues. However, time-consuming…

Image and Video Processing · Electrical Eng. & Systems 2024-11-08 Constantin Berger , Myeongseop Kim , Lukas Scheel-Platz , Vasilis Ntziachristos , Dominik Jüstel , Miguel A. Pleitez

Two-dimensional materials and their van der Waals heterostructures enable a large range of applications, including label-free biosensing. Lattice mismatch and work function difference in the heterostructure material result in strain and…

Mesoscale and Nanoscale Physics · Physics 2021-11-19 Tetyana Ignatova , Sajedeh Pourianejad , Xinyi Li , Kirby Schmidt , Frederick Aryeetey , Shyam Aravamudhan , Slava V. Rotkin

We present a rapid, large-field bimodal imaging platform that integrates conventional brightfield microscopy with a lensless IR imaging scanner, enabling whole-slide IR image stack acquisition in minutes. Using a dedicated deep learning…