Clinical Feasibility of Label-Free Digital Staining Using Mid-Infrared Microscopy at Subcellular Resolution

L. Duraffourg; H. Borges; M. Fernandes; M. Beurrier-Bousquet; J. Baraillon; B. Taurel; J. Le Galudec; K. Vianey; C. Maisin; L. Samaison; F. Staroz; M. Dupoy

Clinical Feasibility of Label-Free Digital Staining Using Mid-Infrared Microscopy at Subcellular Resolution

Optics 2026-01-26 v1 Image and Video Processing Biological Physics

Authors: L. Duraffourg , H. Borges , M. Fernandes , M. Beurrier-Bousquet , J. Baraillon , B. Taurel , J. Le Galudec , K. Vianey , C. Maisin , L. Samaison , F. Staroz , M. Dupoy

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Abstract

We present a rapid, large-field bimodal imaging platform that integrates conventional brightfield microscopy with a lensless IR imaging scanner, enabling whole-slide IR image stack acquisition in minutes. Using a dedicated deep learning model, we implement an optical HE staining strategy based on subcellular morpho-spectral fingerprinting.

Keywords

label-free digital staining mid-infrared microscopy deep learning subcellular resolution whole-slide imaging optical HE staining

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@article{arxiv.2601.16904,
  title  = {Clinical Feasibility of Label-Free Digital Staining Using Mid-Infrared Microscopy at Subcellular Resolution},
  author = {L. Duraffourg and H. Borges and M. Fernandes and M. Beurrier-Bousquet and J. Baraillon and B. Taurel and J. Le Galudec and K. Vianey and C. Maisin and L. Samaison and F. Staroz and M. Dupoy},
  journal= {arXiv preprint arXiv:2601.16904},
  year   = {2026}
}

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33 pages, 15 figures

Clinical Feasibility of Label-Free Digital Staining Using Mid-Infrared Microscopy at Subcellular Resolution

Abstract

Keywords

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