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This study investigates the potential of multimodal data integration, which combines electroencephalogram (EEG) data with sociodemographic characteristics like age, sex, education, and intelligence quotient (IQ), to diagnose mental diseases…

Machine Learning · Computer Science 2025-02-07 Himanshi Singh , Sadhana Tiwari , Sonali Agarwal , Ritesh Chandra , Sanjay Kumar Sonbhadra , Vrijendra Singh

Background: The evolution of symptoms over time is at the heart of understanding and treating mental disorders. However, a principled, quantitative framework explaining symptom dynamics remains elusive. Here, we propose a Network Control…

Personalized healthcare decisions require reasoning about how physiological and behavioral variables influence an individual patient over time. Existing temporal causal discovery methods are poorly matched to this setting: cohort-level…

Machine Learning · Computer Science 2026-05-11 Elahe Khatibi , Ziyu Wang , Saba A. Farahani , Di Huang , Hung Cao , Ramesh Jain , Amir M. Rahmani

This review provides a dynamical systems perspective on psychiatric symptoms and disease, and discusses its potential implications for diagnosis, prognosis, and treatment. After a brief introduction into the theory of dynamical systems, we…

Neurons and Cognition · Quantitative Biology 2018-09-18 Daniel Durstewitz , Quentin J. M. Huys , Georgia Koppe

This study addresses the challenges of symptom evolution complexity and insufficient temporal dependency modeling in Parkinson's disease progression prediction. It proposes a unified prediction framework that integrates structural…

Machine Learning · Computer Science 2025-08-22 Jiacheng Hu , Bo Zhang , Ting Xu , Haifeng Yang , Min Gao

We develop a data-driven co-segmentation algorithm of passively sensed and self-reported active variables collected through smartphones to identify emotionally stressful states in middle-aged and older patients with mood disorders…

Applications · Statistics 2025-04-07 Younghoon Kim , Sumanta Basu , Samprit Banerjee

In this paper, we characterize major depression (MD) as a complex dynamical system in which symptoms (e.g., insomnia and fatigue) are directly connected to one another in a network structure. We hypothesize that individuals can be…

Causal discovery uncovers complex relationships between variables, enhancing predictions, decision-making, and insights into real-world systems, especially in nonlinear multivariate time series. However, most existing methods primarily…

Machine Learning · Computer Science 2025-10-30 Wasim Ahmad , Joachim Denzler , Maha Shadaydeh

Current diagnostic practice in psychiatry is not relying on objective biophysical evidence. Recent pandemic emphasized the need to address the rising number of mood disorders (in particular, depression) cases in a more efficient way. We are…

Neurons and Cognition · Quantitative Biology 2021-10-26 Milena B. Čukić

Many diseases display heterogeneity in clinical features and their progression, indicative of the existence of disease subtypes. Extracting patterns of disease variable progression for subtypes has tremendous application in medicine, for…

Quantitative Methods · Quantitative Biology 2020-08-04 Sanjukta Krishnagopal

Differential diagnosis of mental disorders remains a fundamental challenge in real-world clinical practice, where multiple conditions often exhibit overlapping symptoms. However, most existing public datasets are developed under…

Understanding how neural dynamics shape cognitive experiences remains a central challenge in neuroscience and psychiatry. Here, we present a novel framework leveraging state-to-output controllability from dynamical systems theory to model…

Data-driven approaches for depression diagnosis have emerged as a significant research focus in neuromedicine, driven by the development of relevant datasets. Recently, graph neural network (GNN)-based models have gained widespread adoption…

Machine Learning · Computer Science 2025-05-01 Chengkai Yang , Xingping Dong , Xiaofen Zong

The rapid advancement of medical technology has led to an exponential increase in multi-modal medical data, including imaging, genomics, and electronic health records (EHRs). Graph neural networks (GNNs) have been widely used to represent…

Quantitative Methods · Quantitative Biology 2024-10-03 Favour Nerrise , Alice Louise Heiman , Ehsan Adeli

Comorbid diseases co-occur and progress via complex temporal patterns that vary among individuals. In electronic health records we can observe the different diseases a patient has, but can only infer the temporal relationship between each…

Machine Learning · Computer Science 2020-01-22 Zhaozhi Qian , Ahmed M. Alaa , Alexis Bellot , Jem Rashbass , Mihaela van der Schaar

Predicting the presence of major depressive disorder (MDD) using behavioural and cognitive signals is a highly non-trivial task. The heterogeneous clinical profile of MDD means that any given speech, facial expression and/or observed…

Machine Learning · Computer Science 2023-06-26 Salvatore Fara , Orlaith Hickey , Alexandra Georgescu , Stefano Goria , Emilia Molimpakis , Nicholas Cummins

Predicting the status of Major Depressive Disorder (MDD) from objective, non-invasive methods is an active research field. Yet, extracting automatically objective, interpretable features for a detailed analysis of the patient state remains…

Computer Vision and Pattern Recognition · Computer Science 2026-01-28 Fouad Boutaleb , Emery Pierson , Mohamed Daoudi , Clémence Nineuil , Ali Amad , Fabien D'Hondt

Treatment of cancer involves heterogeneous, complex care pathways. The relationship between these longitudinal trajectories, baseline mental health, and prognostic outcomes remains poorly understood. We introduce an interpretable…

Time series data are found in many areas of healthcare such as medical time series, electronic health records (EHR), measurements of vitals, and wearable devices. Causal discovery, which involves estimating causal relationships from…

Machine Learning · Computer Science 2023-10-18 Muhammad Hasan Ferdous , Uzma Hasan , Md Osman Gani

Discovering causal relationships in complex multivariate time series is a fundamental scientific challenge. Traditional methods often falter, either by relying on restrictive linear assumptions or on conditional independence tests that…

Machine Learning · Computer Science 2025-08-05 Gian Marco Paldino , Gianluca Bontempi
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