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Deep learning approaches have produced substantial breakthroughs in fields such as image classification and natural language processing and are making rapid inroads in the area of protein design. Many generative models of proteins have been…

Machine Learning · Computer Science 2021-09-29 Alexey Strokach , Philip M. Kim

Over the last several years, the field of natural language processing has been propelled forward by an explosion in the use of deep learning models. This survey provides a brief introduction to the field and a quick overview of deep…

Computation and Language · Computer Science 2019-12-24 Daniel W. Otter , Julian R. Medina , Jugal K. Kalita

Modeling long texts has been an essential technique in the field of natural language processing (NLP). With the ever-growing number of long documents, it is important to develop effective modeling methods that can process and analyze such…

Computation and Language · Computer Science 2025-06-11 Zican Dong , Tianyi Tang , Junyi Li , Wayne Xin Zhao

Computational models starting from large ensembles of evolutionarily related protein sequences capture a representation of protein families and learn constraints associated to protein structure and function. They thus open the possibility…

Biomolecules · Quantitative Biology 2024-12-30 Damiano Sgarbossa , Umberto Lupo , Anne-Florence Bitbol

The remarkable performance of the Transformer architecture in natural language processing has recently also triggered broad interest in Computer Vision. Among other merits, Transformers are witnessed as capable of learning long-range…

Computer Vision and Pattern Recognition · Computer Science 2023-11-07 Reza Azad , Amirhossein Kazerouni , Moein Heidari , Ehsan Khodapanah Aghdam , Amirali Molaei , Yiwei Jia , Abin Jose , Rijo Roy , Dorit Merhof

This paper investigates the application of the transformer architecture in protein folding, as exemplified by DeepMind's AlphaFold project, and its implications for the understanding of so-called large language models. The prevailing…

Computers and Society · Computer Science 2024-12-10 Fabian Offert , Paul Kim , Qiaoyu Cai

Transformers have dominated empirical machine learning models of natural language processing. In this paper, we introduce basic concepts of Transformers and present key techniques that form the recent advances of these models. This includes…

Computation and Language · Computer Science 2023-11-30 Tong Xiao , Jingbo Zhu

This paper presents a comprehensive survey of research works on the topic of form understanding in the context of scanned documents. We delve into recent advancements and breakthroughs in the field, highlighting the significance of language…

Computation and Language · Computer Science 2024-03-08 Abdelrahman Abdallah , Daniel Eberharter , Zoe Pfister , Adam Jatowt

Attention-based models trained on protein sequences have demonstrated incredible success at classification and generation tasks relevant for artificial intelligence-driven protein design. However, we lack a sufficient understanding of how…

Machine Learning · Computer Science 2022-06-29 Erik Nijkamp , Jeffrey Ruffolo , Eli N. Weinstein , Nikhil Naik , Ali Madani

Transformer-based pretrained language models (T-PTLMs) have achieved great success in almost every NLP task. The evolution of these models started with GPT and BERT. These models are built on the top of transformers, self-supervised…

Computation and Language · Computer Science 2021-08-31 Katikapalli Subramanyam Kalyan , Ajit Rajasekharan , Sivanesan Sangeetha

Recent developments in Natural Language Processing (NLP) demonstrate that large-scale, self-supervised pre-training can be extremely beneficial for downstream tasks. These ideas have been adapted to other domains, including the analysis of…

Computation and Language · Computer Science 2021-02-02 Matthew B. A. McDermott , Brendan Yap , Harry Hsu , Di Jin , Peter Szolovits

Transformer architectures have facilitated the development of large-scale and general-purpose sequence models for prediction tasks in natural language processing and computer vision, e.g., GPT-3 and Swin Transformer. Although originally…

Machine Learning · Computer Science 2023-06-27 Muning Wen , Runji Lin , Hanjing Wang , Yaodong Yang , Ying Wen , Luo Mai , Jun Wang , Haifeng Zhang , Weinan Zhang

This paper introduces diffusion protein language model (DPLM), a versatile protein language model that demonstrates strong generative and predictive capabilities for protein sequences. We first pre-train scalable DPLMs from…

Machine Learning · Computer Science 2024-10-17 Xinyou Wang , Zaixiang Zheng , Fei Ye , Dongyu Xue , Shujian Huang , Quanquan Gu

Deep neural networks, particularly Transformers, have been widely adopted for predicting the functional properties of proteins. In this work, we focus on exploring whether Protein Transformers can capture biological intelligence among…

Machine Learning · Computer Science 2025-06-10 Fudong Lin , Wanrou Du , Jinchan Liu , Tarikul Milon , Shelby Meche , Wu Xu , Xiaoqi Qin , Xu Yuan

Pre-trained LLMs have demonstrated substantial capabilities across a range of conventional natural language processing (NLP) tasks, such as summarization and entity recognition. In this paper, we explore the application of LLMs in the…

Quantitative Methods · Quantitative Biology 2024-08-14 Kamyar Zeinalipour , Neda Jamshidi , Monica Bianchini , Marco Maggini , Marco Gori

Transformer-based Large Language Models (LLMs) have been applied in diverse areas such as knowledge bases, human interfaces, and dynamic agents, and marking a stride towards achieving Artificial General Intelligence (AGI). However, current…

Computation and Language · Computer Science 2024-02-27 Yunpeng Huang , Jingwei Xu , Junyu Lai , Zixu Jiang , Taolue Chen , Zenan Li , Yuan Yao , Xiaoxing Ma , Lijuan Yang , Hao Chen , Shupeng Li , Penghao Zhao

We consider the protein sequence engineering problem, which aims to find protein sequences with high fitness levels, starting from a given wild-type sequence. Directed evolution has been a dominating paradigm in this field which has an…

Machine Learning · Computer Science 2025-01-20 Yinkai Wang , Jiaxing He , Yuanqi Du , Xiaohui Chen , Jianan Canal Li , Li-Ping Liu , Xiaolin Xu , Soha Hassoun

The emergence of Pre-trained Language Models (PLMs) has achieved tremendous success in the field of Natural Language Processing (NLP) by learning universal representations on large corpora in a self-supervised manner. The pre-trained models…

Information Retrieval · Computer Science 2023-09-14 Peng Liu , Lemei Zhang , Jon Atle Gulla

Transformer language models have received widespread public attention, yet their generated text is often surprising even to NLP researchers. In this survey, we discuss over 250 recent studies of English language model behavior before…

Computation and Language · Computer Science 2023-08-29 Tyler A. Chang , Benjamin K. Bergen

Language models (LMs) are being scaled and becoming powerful. Improving their efficiency is one of the core research topics in neural information processing systems. Tay et al. (2022) provided a comprehensive overview of efficient…

Machine Learning · Computer Science 2023-06-06 Meng Jiang , Hy Dang , Lingbo Tong