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Computational analysis of whole slide images (WSIs) has seen significant research progress in recent years, with applications ranging across important diagnostic and prognostic tasks such as survival or cancer subtype prediction. Many…

Computer Vision and Pattern Recognition · Computer Science 2024-11-28 Zak Buzzard , Konstantin Hemker , Nikola Simidjievski , Mateja Jamnik

Understanding the conformational evolution of $\beta$-amyloid ($A\beta$), particularly the $A\beta_{42}$ isoform, is fundamental to elucidating the pathogenic mechanisms underlying Alzheimer's disease. However, existing end-to-end deep…

Machine Learning · Computer Science 2026-02-24 Qianfeng Yu , Ningkang Peng , Yanhui Gu

Visualizing data is often a crucial first step in data analytics workflows, but growing data sizes pose challenges due to computational and visual perception limitations. As a result, data analysts commonly down-sample their data and work…

Human-Computer Interaction · Computer Science 2025-06-04 Zafeiria Moumoulidou , Hamza Elhamdadi , Ke Yang , Subrata Mitra , Cindy Xiong Bearfield , Alexandra Meliou

One of the challenges facing the adoption of digital pathology workflows for clinical use is the need for automated quality control. As the scanners sometimes determine focus inaccurately, the resultant image blur deteriorates the scanned…

Image and Video Processing · Electrical Eng. & Systems 2018-11-16 Mahdi S. Hosseini , Yueyang Zhang , Lyndon Chan , Konstantinos N. Plataniotis , Jasper A. Z. Brawley-Hayes , Savvas Damaskinos

Accurate analysis of histopathological images is critical for disease diagnosis and treatment planning. Whole-slide images (WSIs), which digitize tissue specimens at gigapixel resolution, are fundamental to this process but require…

Computer Vision and Pattern Recognition · Computer Science 2026-05-07 Enhui Chai , Sicheng Chen , Tianyi Zhang , Chad Wong , Kecheng Huang , Zeyu Liu , Fei Xia

We propose a novel certified defense method for Image Quality Assessment (IQA) models based on randomized smoothing with noise applied in the feature space rather than the input space. Unlike prior approaches that inject Gaussian noise…

Computer Vision and Pattern Recognition · Computer Science 2025-08-08 Ekaterina Shumitskaya , Dmitriy Vatolin , Anastasia Antsiferova

In histopathology, intelligent diagnosis of Whole Slide Images (WSIs) is essential for automating and objectifying diagnoses, reducing the workload of pathologists. However, diagnostic models often face the challenge of forgetting…

Computer Vision and Pattern Recognition · Computer Science 2025-03-26 Weixi Zheng , Aoling Huang , Jingping Yuan , Haoyu Zhao , Zhou Zhao , Yongchao Xu , Thierry Géraud

Histopathological images (HIs) are the gold standard for evaluating some types of tumors for cancer diagnosis. The analysis of such images is not only time and resource consuming, but also very challenging even for experienced pathologists,…

Computer Vision and Pattern Recognition · Computer Science 2021-02-09 Jonathan de Matos , Steve Tsham Mpinda Ataky , Alceu de Souza Britto , Luiz Eduardo Soares de Oliveira , Alessandro Lameiras Koerich

Computational histopathology image diagnosis becomes increasingly popular and important, where images are segmented or classified for disease diagnosis by computers. While pathologists do not struggle with color variations in slides,…

Image and Video Processing · Electrical Eng. & Systems 2020-07-27 Hanwen Liang , Konstantinos N. Plataniotis , Xingyu Li

Self-supervised vision models have achieved notable success in digital pathology. However, their domain-agnostic transformer architectures are not originally designed to account for fundamental biological elements of histopathology images,…

Computer Vision and Pattern Recognition · Computer Science 2026-03-03 Sevda Öğüt , Cédric Vincent-Cuaz , Natalia Dubljevic , Carlos Hurtado , Vaishnavi Subramanian , Pascal Frossard , Dorina Thanou

Foundation models in digital pathology use massive datasets to learn useful compact feature representations of complex histology images. However, there is limited transparency into what drives the correlation between dataset size and…

Histopathology remains the gold standard for cancer diagnosis because it provides detailed cellular-level assessment of tissue morphology. However, manual histopathological examination is time-consuming, labour-intensive, and subject to…

Computer Vision and Pattern Recognition · Computer Science 2026-03-13 Ravi Mosalpuri , Mohammed Abdelsamea , Ahmed Karam Eldaly

Histopathological image analysis is an essential process for the discovery of diseases such as cancer. However, it is challenging to train CNN on whole slide images (WSIs) of gigapixel resolution considering the available memory capacity.…

Image and Video Processing · Electrical Eng. & Systems 2019-10-11 Shusuke Takahama , Yusuke Kurose , Yusuke Mukuta , Hiroyuki Abe , Masashi Fukayama , Akihiko Yoshizawa , Masanobu Kitagawa , Tatsuya Harada

Breast cancer is a health problem that affects mainly the female population. An early detection increases the chances of effective treatment, improving the prognosis of the disease. In this regard, computational tools have been proposed to…

Computer Vision and Pattern Recognition · Computer Science 2022-03-01 Steve Tsham Mpinda Ataky , Alessandro Lameiras Koerich

Image quality assessment (IQA) is an active research area in the field of image processing. Most prior works focus on visual quality of natural images captured by cameras. In this paper, we explore visual quality of scanned documents,…

Image and Video Processing · Electrical Eng. & Systems 2023-07-26 Justin Yang , Peter Bauer , Todd Harris , Changhyung Lee , Hyeon Seok Seo , Jan P Allebach , Fengqing Zhu

Digitized Histological diagnosis is in increasing demand. However, color variations due to various factors are imposing obstacles to the diagnosis process. The problem of stain color variations is a well-defined problem with many proposed…

Computer Vision and Pattern Recognition · Computer Science 2018-04-06 M Tarek Shaban , Christoph Baur , Nassir Navab , Shadi Albarqouni

The microscopic examination of surgical tissue remains a cornerstone of disease classification but relies on subjective interpretations and access to highly specialized experts, which can compromise accuracy and clinical care. While…

Blind image quality assessment (BIQA) aims to predict perceptual image quality scores without access to reference images. State-of-the-art BIQA methods typically require subjects to score a large number of images to train a robust model.…

Computer Vision and Pattern Recognition · Computer Science 2019-04-25 Fei Gao , Dacheng Tao , Xinbo Gao , Xuelong Li

Recent advances in deep learning and on-device inference could transform routine screening for skin cancers. Along with the anticipated benefits of this technology, potential dangers arise from unforeseen and inherent biases. A significant…

Computer Vision and Pattern Recognition · Computer Science 2025-12-23 Ko Watanabe , Stanislav Frolov , Aya Hassan , David Dembinsky , Adriano Lucieri , Andreas Dengel

Interpretability is crucial to enhance trust in machine learning models for medical diagnostics. However, most state-of-the-art image classifiers based on neural networks are not interpretable. As a result, clinicians often resort to known…

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