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We develop statistically based methods to detect single nucleotide DNA mutations in next generation sequencing data. Sequencing generates counts of the number of times each base was observed at hundreds of thousands to billions of genome…

Applications · Statistics 2012-10-01 Omkar Muralidharan , Georges Natsoulis , John Bell , Hanlee Ji , Nancy R. Zhang

We consider the problem of evaluating dynamic consistency in discrete time probabilistic filters that approximate stochastic system state densities with Gaussian mixtures. Dynamic consistency means that the estimated probability…

Methodology · Statistics 2024-03-18 Nisar Ahmed , Luke Burks , Kailah Cabral , Alyssa Bekai Rose

Deep Neural Networks (DNNs) are increasingly deployed in safety-critical applications including autonomous vehicles and medical diagnostics. To reduce the residual risk for unexpected DNN behaviour and provide evidence for their trustworthy…

Software Engineering · Computer Science 2019-02-19 Hasan Ferit Eniser , Simos Gerasimou , Alper Sen

Big-data applications often involve a vast number of observations and features, creating new challenges for variable selection and parameter estimation. This paper presents a novel technique called ``slow kill,'' which utilizes nonconvex…

Machine Learning · Statistics 2023-05-04 Yiyuan She , Jianhui Shen , Adrian Barbu

Over the past few years, deep neural networks (DNNs) have been continuously expanding their real-world applications for source code processing tasks across the software engineering domain, e.g., clone detection, code search, comment…

Software Engineering · Computer Science 2021-01-21 Maryam Vahdat Pour , Zhuo Li , Lei Ma , Hadi Hemmati

In evolutionary game theory, an important measure of a mutant trait (strategy) is its ability to invade and take over an otherwise-monomorphic population. Typically, one quantifies the success of a mutant strategy via the probability that a…

Populations and Evolution · Quantitative Biology 2016-04-12 Alex McAvoy , Christoph Hauert

This paper investigates reinforcement learning with constraints, which are indispensable in safety-critical environments. To drive the constraint violation monotonically decrease, we take the constraints as Lyapunov functions and impose new…

Machine Learning · Computer Science 2021-05-07 Chuangchuang Sun , Dong-Ki Kim , Jonathan P. How

In this article, we introduce a new variable selection technique through trimming for finite mixture of regression models. Compared to the traditional variable selection techniques, the new method is robust and not sensitive to outliers.…

Methodology · Statistics 2019-05-06 Sijia Xiang , Weixin Yao

This paper presents a portable, privacy-preserving, in-browser platform for the reproducible assessment of mutational signature detection methods from sparse sequencing data generated by targeted gene panels. The platform aims to address…

Genomics · Quantitative Biology 2023-06-05 Aaron Ge , Tongwu Zhang , Clara Bodelon , Montserrat Garcia-Closas , Jonas Almeida , Jeya Balasubramanian

Permutation tests are a distribution free way of performing hypothesis tests. These tests rely on the condition that the observed data are exchangeable among the groups being tested under the null hypothesis. This assumption is easily…

Methodology · Statistics 2017-12-14 Daniell Toth

Mutation analysis evaluates test suites and testing techniques by measuring how well they detect seeded defects (mutants). Even though well established in research, mutation analysis is rarely used in practice due to scalability problems…

Software Engineering · Computer Science 2013-03-13 René Just , Michael D. Ernst , Gordon Fraser

I introduce a simple permutation procedure to test conventional (non-sharp) hypotheses about the effect of a binary treatment in the presence of a finite number of large, heterogeneous clusters when the treatment effect is identified by…

Econometrics · Economics 2023-02-08 Andreas Hagemann

Compression techniques for deep neural network models are becoming very important for the efficient execution of high-performance deep learning systems on edge-computing devices. The concept of model compression is also important for…

In an ever expanding set of research and application areas, deep neural networks (DNNs) set the bar for algorithm performance. However, depending upon additional constraints such as processing power and execution time limits, or…

Machine Learning · Computer Science 2021-06-22 Nathan Dahlin , Krishna Chaitanya Kalagarla , Nikhil Naik , Rahul Jain , Pierluigi Nuzzo

Deep neural networks (DNNs) have a wide range of applications, and software employing them must be thoroughly tested, especially in safety-critical domains. However, traditional software test coverage metrics cannot be applied directly to…

Machine Learning · Computer Science 2019-04-16 Youcheng Sun , Xiaowei Huang , Daniel Kroening , James Sharp , Matthew Hill , Rob Ashmore

Deep Learning (DL) components are routinely integrated into software systems that need to perform complex tasks such as image or natural language processing. The adequacy of the test data used to test such systems can be assessed by their…

Software Engineering · Computer Science 2021-09-17 Vincenzo Riccio , Nargiz Humbatova , Gunel Jahangirova , Paolo Tonella

This project explores adversarial training techniques to develop fairer Deep Neural Networks (DNNs) to mitigate the inherent bias they are known to exhibit. DNNs are susceptible to inheriting bias with respect to sensitive attributes such…

Machine Learning · Computer Science 2024-01-05 Allen Minch , Hung Anh Vu , Anne Marie Warren

Neural models, with their ability to provide novel representations, have shown promising results in prediction tasks in healthcare. However, patient demographics, medical technology, and quality of care change over time. This often leads to…

Machine Learning · Computer Science 2022-12-02 Miguel Rios , Ameen Abu-Hanna

Quantification learning deals with the task of estimating the target label distribution under label shift. In this paper, we first present a unifying framework, distribution feature matching (DFM), that recovers as particular instances…

Machine Learning · Statistics 2023-07-04 Bastien Dussap , Gilles Blanchard , Badr-Eddine Chérief-Abdellatif

Testing for normality is a widely used procedure in statistics and data analysis, often applied prior to employing methods that rely on the assumption of normally distributed data. While several existing tests target distributional…

Methodology · Statistics 2026-04-07 Akin Anarat , Holger Schwender
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