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Early and accurate diagnosis of Alzheimer's disease (AD) and its prodromal period mild cognitive impairment (MCI) is essential for the delayed disease progression and the improved quality of patients'life. The emerging computer-aided…

Image and Video Processing · Electrical Eng. & Systems 2021-07-29 Fan Zhang , Bo Pan , Pengfei Shao , Peng Liu , Shuwei Shen , Peng Yao , Ronald X. Xu

Mental health issues, particularly depressive disorders, present significant challenges in contemporary society, necessitating the development of effective automated diagnostic methods. This paper introduces the Agent Mental Clinic (AMC), a…

Computation and Language · Computer Science 2024-10-10 Kunyao Lan , Bingrui Jin , Zichen Zhu , Siyuan Chen , Shu Zhang , Kenny Q. Zhu , Mengyue Wu

Depression detection research has increased over the last few decades, one major bottleneck of which is the limited data availability and representation learning. Recently, self-supervised learning has seen success in pretraining text…

Human-Computer Interaction · Computer Science 2021-10-29 Pingyue Zhang , Mengyue Wu , Heinrich Dinkel , Kai Yu

The differential diagnosis of neurodegenerative dementias is a challenging clinical task, mainly because of the overlap in symptom presentation and the similarity of patterns observed in structural neuroimaging. To improve diagnostic…

Machine Learning · Computer Science 2025-05-27 Andrew Zamai , Nathanael Fijalkow , Boris Mansencal , Laurent Simon , Eloi Navet , Pierrick Coupe

Depression is a common mental disorder worldwide which causes a range of serious outcomes. The diagnosis of depression relies on patient-reported scales and psychiatrist interview which may lead to subjective bias. In recent years, more and…

Audio and Speech Processing · Electrical Eng. & Systems 2020-03-02 Zhenyu Liu , Dongyu Wang , Lan Zhang , Bin Hu

Background: Alzheimer's disease and related dementias (ADRD) are progressive neurodegenerative conditions where early detection is vital for timely intervention and care. Spontaneous speech contains rich acoustic and linguistic markers that…

Computation and Language · Computer Science 2025-06-16 Jingyu Li , Lingchao Mao , Hairong Wang , Zhendong Wang , Xi Mao , Xuelei Sherry Ni

Depression is a widespread mental disorder that affects millions worldwide. While automated depression assessment shows promise, most studies rely on limited or non-clinically validated data, and often prioritize complex model design over…

Computation and Language · Computer Science 2025-08-07 Zhuang Chen , Guanqun Bi , Wen Zhang , Jiawei Hu , Aoyun Wang , Xiyao Xiao , Kun Feng , Minlie Huang

Speech is usually used for constructing an automatic Alzheimer's dementia (AD) detection system, as the acoustic and linguistic abilities show a decline in people living with AD at the early stages. However, speech includes not only…

Audio and Speech Processing · Electrical Eng. & Systems 2024-10-11 Yilin Pan , Yanpei Shi , Yijia Zhang , Mingyu Lu

The automatic, sensor-based assessment of challenging behavior of persons with dementia is an important task to support the selection of interventions. However, predicting behaviors like apathy and agitation is challenging due to the large…

Machine Learning · Computer Science 2024-08-13 Maximilian Popko , Sebastian Bader , Stefan Lüdtke , Thomas Kirste

Collecting and accessing a large amount of medical data is very time-consuming and laborious, not only because it is difficult to find specific patients but also because it is required to resolve the confidentiality of a patient's medical…

Sound · Computer Science 2021-03-04 Junghyun Koo , Jie Hwan Lee , Jaewoo Pyo , Yujin Jo , Kyogu Lee

The diversity of cognitive deficits and neuropathological processes associated with dementias has encouraged divergence in pathophysiological explanations of disease. Here, we review an alternative framework that emphasises convergent…

Neurons and Cognition · Quantitative Biology 2020-06-12 Ece Kocagoncu , Anastasia Klimovich-Gray , Laura E Hughes , James B Rowe

Patients with semantic dementia (SD) present with remarkably consistent atrophy of neurons in the anterior temporal lobe and behavioural impairments, such as graded loss of category knowledge. While relearning of lost knowledge has been…

Machine Learning · Computer Science 2025-03-06 Devon Jarvis , Verena Klar , Richard Klein , Benjamin Rosman , Andrew Saxe

Increasing effort in brain image analysis has been dedicated to early diagnosis of Alzheimer's disease (AD) based on neuroimaging data. Most existing studies have been focusing on binary classification problems, e.g., distinguishing AD…

Computer Vision and Pattern Recognition · Computer Science 2017-09-14 Hongming Li , Mohamad Habes , Yong Fan

Alzheimer's disease (AD) is known as one of the major causes of dementia and is characterized by slow progression over several years, with no treatments or available medicines. In this regard, there have been efforts to identify the risk of…

Computer Vision and Pattern Recognition · Computer Science 2020-08-28 Wonsik Jung , Eunji Jun , Heung-Il Suk

Alzheimer's disease (AD) is the most common type of dementia accompanied with brain atrophy. Structural measurements of brain atrophy in specific brain structures such as hippocampus using magnetic resonance imaging (MRI) have been reported…

Medical Physics · Physics 2016-05-10 Kenya Murase , Naohiko Gondo , Tsutomu Soma

Alzheimer's disease (AD) progresses through distinct stages, from early mild cognitive impairment (EMCI) to late mild cognitive impairment (LMCI) and eventually to AD. Accurate identification of these stages, especially distinguishing LMCI…

Computer Vision and Pattern Recognition · Computer Science 2025-01-13 Aswini Kumar Patra , Soraisham Elizabeth Devi , Tejashwini Gajurel

Alzheimer's Disease (AD) is the most common type of dementia. In all leading countries, it is one of the primary reasons of death in senior citizens. Currently, it is diagnosed by calculating the MSME score and by the manual study of MRI…

Machine Learning · Computer Science 2019-12-11 Rishu Garg , Rekh Ram Janghel , Yogesh Rathore

Objective Alzheimer disease (AD) is the most common cause of dementia, a syndrome characterized by cognitive impairment severe enough to interfere with activities of daily life. We aimed to conduct a systematic literature review (SLR) of…

Quantitative Methods · Quantitative Biology 2021-08-31 Sayantan Kumar , Inez Oh , Suzanne Schindler , Albert M Lai , Philip R O Payne , Aditi Gupta

Aging associated brain decline often result in some kind of dementia. Even when this is a complex brain disorder a physical model can be used in order to describe its general behavior. This model is based in first principles. A…

Neurons and Cognition · Quantitative Biology 2016-07-22 Oscar Sotolongo-Costa , L. M. Gaggero-Sager , J. T. Becker , F. Maestú , O. Sotolongo-Grau