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LLMs promise to overcome limitations of rule-based mental health chatbots through improved natural language capabilities, yet their ability to deliver evidence-based psychological interventions remains largely unverified because evaluations…

Human-Computer Interaction · Computer Science 2025-12-22 Florian Onur Kuhlmeier , Leon Hanschmann , Melina Rabe , Stefan Luettke , Eva-Lotta Brakemeier , Alexander Maedche

Recent advancements in large language models (LLMs) promise to expand mental health interventions by emulating therapeutic techniques, potentially easing barriers to care. Yet there is a lack of real-world empirical evidence evaluating the…

Human-Computer Interaction · Computer Science 2025-01-28 Yinzhou Wang , Yimeng Wang , Ye Xiao , Liabette Escamilla , Bianca Augustine , Kelly Crace , Gang Zhou , Yixuan Zhang

Large Language Models (LLMs) are widely used in healthcare, but limitations like hallucinations, incomplete information, and bias hinder their reliability. To address these, researchers released the Build Your Own expert Bot (BYOeB)…

Human-Computer Interaction · Computer Science 2024-09-18 Bhuvan Sachdeva , Pragnya Ramjee , Geeta Fulari , Kaushik Murali , Mohit Jain

Background: Clinical guidelines are central to safe evidence-based medicine in modern healthcare, providing diagnostic criteria, treatment options and monitoring advice for a wide range of illnesses. LLM-empowered chatbots have shown great…

Computation and Language · Computer Science 2025-05-07 Julia Ive , Felix Jozsa , Nick Jackson , Paulina Bondaronek , Ciaran Scott Hill , Richard Dobson

LGBTQ+ individuals are increasingly turning to chatbots powered by large language models (LLMs) to meet their mental health needs. However, little research has explored whether these chatbots can adequately and safely provide tailored…

Human-Computer Interaction · Computer Science 2024-02-15 Zilin Ma , Yiyang Mei , Yinru Long , Zhaoyuan Su , Krzysztof Z. Gajos

People experiencing severe distress increasingly use Large Language Model (LLM) chatbots as mental health support tools. Discussions on social media have described how engagements were lifesaving for some, but evidence suggests that…

Human-Computer Interaction · Computer Science 2025-05-12 Inhwa Song , Sachin R. Pendse , Neha Kumar , Munmun De Choudhury

Personalized support is essential to fulfill individuals' emotional needs and sustain their mental well-being. Large language models (LLMs), with great customization flexibility, hold promises to enable individuals to create their own…

Human-Computer Interaction · Computer Science 2025-05-01 Xi Zheng , Zhuoyang Li , Xinning Gui , Yuhan Luo

Recent research leverages large language models (LLMs) for early mental health detection, such as depression, often optimized with machine-generated data. However, their detection may be subject to unknown weaknesses. Meanwhile, quality…

Computation and Language · Computer Science 2025-05-26 Zongru Shao , Xin Wang , Zhanyang Liu , Chenhan Wang , K. P. Subbalakshmi

Purpose: To assess the alignment of GPT-4-based evaluation to human clinician experts, for the evaluation of responses to ophthalmology-related patient queries generated by fine-tuned LLM chatbots. Methods: 400 ophthalmology questions and…

Artificial Intelligence · Computer Science 2024-02-16 Ting Fang Tan , Kabilan Elangovan , Liyuan Jin , Yao Jie , Li Yong , Joshua Lim , Stanley Poh , Wei Yan Ng , Daniel Lim , Yuhe Ke , Nan Liu , Daniel Shu Wei Ting

Existing depression screening predominantly relies on standardized questionnaires (e.g., PHQ-9, BDI), which suffer from high misdiagnosis rates (18-34% in clinical studies) due to their static, symptom-counting nature and susceptibility to…

Neurons and Cognition · Quantitative Biology 2025-04-24 Zhenguang Zhong , Zhixuan Wang

The integration of Large Language Models (LLMs) into healthcare settings has gained significant attention, particularly for question-answering tasks. Given the high-stakes nature of healthcare, it is essential to ensure that LLM-generated…

This paper presents ChatCounselor, a large language model (LLM) solution designed to provide mental health support. Unlike generic chatbots, ChatCounselor is distinguished by its foundation in real conversations between consulting clients…

Computation and Language · Computer Science 2023-09-28 June M. Liu , Donghao Li , He Cao , Tianhe Ren , Zeyi Liao , Jiamin Wu

Cognitive reappraisal is a well-studied emotion regulation strategy that helps individuals reinterpret stressful situations to reduce their impact. Many digital mental health tools struggle to support this process because rigid scripts fail…

Human-Computer Interaction · Computer Science 2026-01-05 Ananya Bhattacharjee , Jina Suh , Mohit Chandra , Javier Hernandez

Large language model (LLM) based chatbots show promise in persuasive communication, but existing studies often rely on weak controls or focus on belief change rather than behavioral intentions or outcomes. This pre-registered multi-country…

Many people suffer from mental health problems but not everyone seeks professional help or has access to mental health care. AI chatbots have increasingly become a go-to for individuals who either have mental disorders or simply want…

Other Quantitative Biology · Quantitative Biology 2025-11-03 Aditya Naik , Jovi Thomas , Teja Sree Mandava , Himavanth Reddy Vemula

Large Language Models have found application in various mundane and repetitive tasks including Human Resource (HR) support. We worked with the domain experts of SAP SE to develop an HR support chatbot as an efficient and effective tool for…

Computation and Language · Computer Science 2024-07-09 Anum Afzal , Alexander Kowsik , Rajna Fani , Florian Matthes

Healthcare systems around the world are grappling with issues like inefficient diagnostics, rising costs, and limited access to specialists. These problems often lead to delays in treatment and poor health outcomes. Most current AI and deep…

Artificial Intelligence · Computer Science 2025-12-22 Maliha Tabassum , M Shamim Kaiser

Depression is a major contributor to the mental-health burden in Nigeria, yet screening coverage remains limited due to low access to clinicians, stigma, and language barriers. Traditional tools like the Patient Health Questionnaire-9…

Large Language Models (LLMs) are increasingly used not only for instrumental tasks, but as always-available and non-judgmental confidants for emotional support. Yet what drives adoption and how users perceive emotional support interactions…

Computation and Language · Computer Science 2026-05-19 Natalia Amat-Lefort , Mert Yazan , Amanda Cercas Curry , Flor Miriam Plaza-del-Arco

The conversational capabilities of Large Language Models (LLMs) suggest that they may be able to perform as automated talk therapists. It is crucial to know if these systems would be effective and adhere to known standards. We present a…

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