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Objective: Question answering (QA) systems have the potential to improve the quality of clinical care by providing health professionals with the latest and most relevant evidence. However, QA systems have not been widely adopted. This…

Computation and Language · Computer Science 2024-02-06 Gregory Kell , Angus Roberts , Serge Umansky , Linglong Qian , Davide Ferrari , Frank Soboczenski , Byron Wallace , Nikhil Patel , Iain J Marshall

Screening patients for clinical trial eligibility remains a manual, time-consuming, and resource-intensive process. We present a secure, scalable proof-of-concept system for Artificial Intelligence (AI)-augmented patient-trial matching that…

Spatial reasoning and visual grounding are core capabilities for vision-language models (VLMs), yet most medical VLMs produce predictions without transparent reasoning or spatial evidence. Existing benchmarks also evaluate VLMs on isolated…

Computer Vision and Pattern Recognition · Computer Science 2026-04-20 Lama Moukheiber , Caleb M. Yeung , Haotian Xue , Alec Helbling , Zelin Zhao , Yongxin Chen

Evaluating the clinical correctness and reasoning fidelity of automatically generated medical imaging reports remains a critical yet unresolved challenge. Existing evaluation methods often fail to capture the structured diagnostic logic…

Artificial Intelligence · Computer Science 2026-01-26 Suzhong Fu , Jingqi Dong , Xuan Ding , Rui Sun , Yiming Yang , Shuguang Cui , Zhen Li

Existing medical RAG systems mainly leverage knowledge from medical knowledge bases, neglecting the crucial role of experiential knowledge derived from similar patient cases -- a key component of human clinical reasoning. To bridge this…

Computation and Language · Computer Science 2025-05-27 Yuxing Lu , Gecheng Fu , Wei Wu , Xukai Zhao , Sin Yee Goi , Jinzhuo Wang

Paucity of medical data severely limits the generalizability of diagnostic ML models, as the full spectrum of disease variability can not be represented by a small clinical dataset. To address this, diffusion models (DMs) have been…

Computer Vision and Pattern Recognition · Computer Science 2025-10-23 Janet Wang , Yunbei Zhang , Zhengming Ding , Jihun Hamm

To contribute to automating the medical vision-language model, we propose a novel Chest-Xray Difference Visual Question Answering (VQA) task. Given a pair of main and reference images, this task attempts to answer several questions on both…

Computer Vision and Pattern Recognition · Computer Science 2024-08-29 Xinyue Hu , Lin Gu , Qiyuan An , Mengliang Zhang , Liangchen Liu , Kazuma Kobayashi , Tatsuya Harada , Ronald M. Summers , Yingying Zhu

Clinical decision support systems require models that are not only highly accurate but also equitable and sensitive to the implications of missed diagnoses. In this study, we introduce a knowledge-guided in-context learning (ICL) framework…

Machine Learning · Computer Science 2025-07-28 Fatemeh Nazary , Yashar Deldjoo , Tommaso Di Noia , Eugenio di Sciascio

Recent Artificial Intelligence (AI) models have matched or exceeded human experts in several benchmarks of biomedical task performance, but surgical benchmarks in particular are often missing from prominent medical benchmark suites. Since…

Scaling Visual Question Answering (VQA) to the open-domain and multi-hop nature of web searches, requires fundamental advances in visual representation learning, knowledge aggregation, and language generation. In this work, we introduce…

Computation and Language · Computer Science 2022-03-29 Yingshan Chang , Mridu Narang , Hisami Suzuki , Guihong Cao , Jianfeng Gao , Yonatan Bisk

Recent advancements in reasoning-enhanced large language models (LLMs), such as DeepSeek-R1 and OpenAI-o3, have demonstrated significant progress. However, their application in professional medical contexts remains underexplored,…

Computation and Language · Computer Science 2025-03-11 Pengcheng Qiu , Chaoyi Wu , Shuyu Liu , Weike Zhao , Zhuoxia Chen , Hongfei Gu , Chuanjin Peng , Ya Zhang , Yanfeng Wang , Weidi Xie

Clinical reasoning demands multi-step interactions -- gathering patient history, ordering tests, interpreting results, and making safe treatment decisions -- yet a unified training environment provides the breadth of clinical domains and…

Machine Learning · Computer Science 2026-05-06 Minbyul Jeong

Multimodal large language models (MLLMs) demonstrate considerable potential in clinical diagnostics, a domain that inherently requires synthesizing complex visual and textual data alongside consulting authoritative medical literature.…

Computation and Language · Computer Science 2026-03-23 Yannian Gu , Zhongzhen Huang , Linjie Mu , Xizhuo Zhang , Shaoting Zhang , Xiaofan Zhang

Artificial intelligence (AI) is increasingly being considered to assist human decision-making in high-stake domains (e.g. health). However, researchers have discussed an issue that humans can over-rely on wrong suggestions of the AI model…

Human-Computer Interaction · Computer Science 2023-08-09 Min Hun Lee , Chong Jun Chew

Large vision-language models (VLMs) often benefit from chain-of-thought (CoT) prompting in general domains, yet its efficacy in medical vision-language tasks remains underexplored. We report a counter-intuitive trend: on medical visual…

Computer Vision and Pattern Recognition · Computer Science 2026-04-13 Yuan Wu , Zongxian Yang , Jiayu Qian , Songpan Gao , Guanxing Chen , Qiankun Li , Yu-An Huang , Zhi-An Huang

We present Doctorina MedBench, a comprehensive evaluation framework for agent-based medical AI based on the simulation of realistic physician-patient interactions. Unlike traditional medical benchmarks that rely on solving standardized test…

Computation and Language · Computer Science 2026-03-30 Anna Kozlova , Stanislau Salavei , Pavel Satalkin , Hanna Plotnitskaya , Sergey Parfenyuk

Test-time scaling has recently emerged as a promising approach for enhancing the reasoning capabilities of large language models or vision-language models during inference. Although a variety of test-time scaling strategies have been…

Computation and Language · Computer Science 2025-06-17 Gyutaek Oh , Seoyeon Kim , Sangjoon Park , Byung-Hoon Kim

There is a growing need to understand how digital systems can support clinical decision-making, particularly as artificial intelligence (AI) models become increasingly complex and less human-interpretable. This complexity raises concerns…

Large Vision-Language Models (LVLMs) are capable of handling diverse data types such as imaging, text, and physiological signals, and can be applied in various fields. In the medical field, LVLMs have a high potential to offer substantial…

The recent development of data-driven AI promises to automate medical diagnosis; however, most AI functions as 'black boxes' to physicians with limited computational knowledge. Using medical imaging as a point of departure, we conducted…

Human-Computer Interaction · Computer Science 2020-01-22 Yao Xie , Melody Chen , David Kao , Ge Gao , Xiang 'Anthony' Chen
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