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Introduction: Semantic search, which retrieves documents based on conceptual similarity rather than keyword matching, offers substantial advantages for retrieval of clinical information. However, deploying semantic search across entire…

Large language models (LLMs) hold great promise for medical applications and are evolving rapidly, with new models being released at an accelerated pace. However, benchmarking on large-scale real-world data such as electronic health records…

While large language models (LLMs) have shown promise in healthcare, their application for rare medical conditions is still hindered by scarce and unreliable datasets for fine-tuning. Hyperhidrosis, a disorder causing excessive sweating…

Artificial Intelligence · Computer Science 2025-08-22 Wenjie Lin , Jin Wei-Kocsis

Transforming raw EHR data into machine learning model-ready inputs requires considerable effort. One widely used EHR database is Medical Information Mart for Intensive Care (MIMIC). Prior work on MIMIC-III cannot query the updated and…

Databases · Computer Science 2023-11-14 Wei Liao , Joel Voldman

Large Language Models (LLMs) constitute a breakthrough state-of-the-art Artificial Intelligence (AI) technology which is rapidly evolving and promises to aid in medical diagnosis either by assisting doctors or by simulating a doctor's…

Reasoning benchmarks measure clinical performance on clean inputs. We evaluate the step before reasoning: retrieval over real EHR notes, where negation, temporality, and family-versus-patient attribution can flip a correct answer to a wrong…

Computation and Language · Computer Science 2026-05-13 Alex Stinard

Large Language Models (LLMs) have demonstrated remarkable versatility in recent years, offering potential applications across specialized domains such as healthcare and medicine. Despite the availability of various open-source LLMs tailored…

Computation and Language · Computer Science 2024-07-18 Yanis Labrak , Adrien Bazoge , Emmanuel Morin , Pierre-Antoine Gourraud , Mickael Rouvier , Richard Dufour

Extracting clinically relevant information from unstructured medical narratives such as admission notes, discharge summaries, and emergency case histories remains a challenge in clinical natural language processing (NLP). Medical Entity…

Artificial Intelligence · Computer Science 2026-04-21 Nwe Ni Win , Jim Basilakis , Steven Thomas , Seyhan Yazar , Laura Pierce , Stephanie Liu , Paul M. Middleton , Nasser Ghadiri , X. Rosalind Wang

Electronic Health Record (EHR) tables pose unique challenges among which is the presence of hidden contextual dependencies between medical features with a high level of data dimensionality and sparsity. This study presents the first…

Computation and Language · Computer Science 2025-01-17 Jesus Lovon , Martin Mouysset , Jo Oleiwan , Jose G. Moreno , Christine Damase-Michel , Lynda Tamine

Matching patients to clinical trial options is critical for identifying novel treatments, especially in oncology. However, manual matching is labor-intensive and error-prone, leading to recruitment delays. Pipelines incorporating large…

Computation and Language · Computer Science 2025-09-25 Braxton A. Morrison , Madhumita Sushil , Jacob S. Young

Physician burnout in the United States has reached critical levels, driven in part by the administrative burden of Electronic Health Record (EHR) documentation and complex diagnostic codes. To relieve this strain and maintain strict patient…

Information Retrieval · Computer Science 2026-03-25 Peter Hartnett , Chung-Chi Huang , Sarah Hartnett , David Hartnett

Background and Objective: Code assignment is of paramount importance in many levels in modern hospitals, from ensuring accurate billing process to creating a valid record of patient care history. However, the coding process is tedious and…

Computation and Language · Computer Science 2019-10-03 Jinmiao Huang , Cesar Osorio , Luke Wicent Sy

While recent advancements in commercial large language models (LM) have shown promising results in medical tasks, their closed-source nature poses significant privacy and security concerns, hindering their widespread use in the medical…

Computation and Language · Computer Science 2024-07-02 Hyunjae Kim , Hyeon Hwang , Jiwoo Lee , Sihyeon Park , Dain Kim , Taewhoo Lee , Chanwoong Yoon , Jiwoong Sohn , Donghee Choi , Jaewoo Kang

The rapid advancement of Large Language Models (LLMs) has driven significant progress in Natural Language Interface to Database (NLIDB). However, the widespread adoption of LLMs has raised critical privacy and security concerns. During…

Computation and Language · Computer Science 2025-11-12 Ruiheng Liu , XiaoBing Chen , Jinyu Zhang , Qiongwen Zhang , Yu Zhang , Bailong Yang

Identifying medication discontinuations in electronic health records (EHRs) is vital for patient safety but is often hindered by information being buried in unstructured notes. This study aims to evaluate the capabilities of advanced…

Computation and Language · Computer Science 2025-11-10 Chong Shao , Douglas Snyder , Chiran Li , Bowen Gu , Kerry Ngan , Chun-Ting Yang , Jiageng Wu , Richard Wyss , Kueiyu Joshua Lin , Jie Yang

Large language models (LLMs) can potentially democratize access to medical knowledge. While many efforts have been made to harness and improve LLMs' medical knowledge and reasoning capacities, the resulting models are either closed-source…

Integrating language models (LMs) in healthcare systems holds great promise for improving medical workflows and decision-making. However, a critical barrier to their real-world adoption is the lack of reliable evaluation of their…

Computation and Language · Computer Science 2025-12-15 Akash Ghosh , Srivarshinee Sridhar , Raghav Kaushik Ravi , Muhsin Muhsin , Sriparna Saha , Chirag Agarwal

Large language models (LLMs) are increasingly used as personal agents, accessing sensitive user data such as calendars, emails, and medical records. Users currently face a trade-off: They can send private records, many of which are stored…

Cryptography and Security · Computer Science 2025-11-04 Yubeen Bae , Minchan Kim , Jaejin Lee , Sangbum Kim , Jaehyung Kim , Yejin Choi , Niloofar Mireshghallah

Large language models, such as GPT-4 and Med-PaLM, have shown impressive performance on clinical tasks; however, they require access to compute, are closed-source, and cannot be deployed on device. Mid-size models such as BioGPT-large,…

Rare diseases, including Inborn Errors of Metabolism (IEM), pose significant diagnostic challenges. Case reports serve as key but computationally underutilized resources to inform diagnosis. Clinical dense information extraction refers to…

Computation and Language · Computer Science 2025-05-26 Xiao Yu Cindy Zhang , Carlos R. Ferreira , Francis Rossignol , Raymond T. Ng , Wyeth Wasserman , Jian Zhu
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