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The prediction of protein structures from sequences is an important task for function prediction, drug design, and related biological processes understanding. Recent advances have proved the power of language models (LMs) in processing the…

Quantitative Methods · Quantitative Biology 2022-12-01 Bozhen Hu , Jun Xia , Jiangbin Zheng , Cheng Tan , Yufei Huang , Yongjie Xu , Stan Z. Li

Natural language processing (NLP) has been traditionally applied to medicine, and generative large language models (LLMs) have become prominent recently. However, the differences between them across different medical tasks remain…

We investigate how to teach large language models (LLMs) to perform scientific reasoning by leveraging expert discussions as a learning signal. Focusing on the genomics domain, we develop an automated pipeline to extract trainable data and…

Artificial Intelligence · Computer Science 2025-06-04 Ming Yin , Yuanhao Qu , Ling Yang , Le Cong , Mengdi Wang

Large Language Models (LLMs) have reshaped our world with significant advancements in science, engineering, and society through applications ranging from scientific discoveries and medical diagnostics to Chatbots. Despite their ubiquity and…

Artificial Intelligence · Computer Science 2025-08-26 Kushal Raj Bhandari , Pin-Yu Chen , Jianxi Gao

Large language models (LLMs) are beginning to reshape how chemists plan and run reactions in organic synthesis. Trained on millions of reported transformations, these text-based models can propose synthetic routes, forecast reaction…

Artificial Intelligence · Computer Science 2025-08-08 Kartar Kumar Lohana Tharwani , Rajesh Kumar , Sumita , Numan Ahmed , Yong Tang

Sequence-to-sequence learning with neural networks has become the de facto standard for sequence prediction tasks. This approach typically models the local distribution over the next word with a powerful neural network that can condition on…

Computation and Language · Computer Science 2021-11-17 Yoon Kim

Modeling the structure of coherent texts is a key NLP problem. The task of coherently organizing a given set of sentences has been commonly used to build and evaluate models that understand such structure. We propose an end-to-end…

Computation and Language · Computer Science 2017-12-25 Lajanugen Logeswaran , Honglak Lee , Dragomir Radev

This paper demonstrates that language models are strong structure-based protein designers. We present LM-Design, a generic approach to reprogramming sequence-based protein language models (pLMs), that have learned massive sequential…

Machine Learning · Computer Science 2023-02-10 Zaixiang Zheng , Yifan Deng , Dongyu Xue , Yi Zhou , Fei YE , Quanquan Gu

Natural interface to database (NLIDB) has been researched a lot during the past decades. In the core of NLIDB, is a semantic parser used to convert natural language into SQL. Solutions from traditional NLP methodology focuses on grammar…

Computation and Language · Computer Science 2021-06-29 Ruiyang Xu , Ayush Singh

Recent language models, especially those based on recurrent neural networks (RNNs), make it possible to generate natural language from a learned probability. Language generation has wide applications including machine translation,…

Computation and Language · Computer Science 2016-01-05 Lili Mou , Rui Yan , Ge Li , Lu Zhang , Zhi Jin

The impressive performance of large language models (LLMs) has led to their consideration as models of human language processing. Instead, we suggest that the success of LLMs arises from the flexibility of the transformer learning…

Computation and Language · Computer Science 2024-11-19 Xiaoliang Luo , Michael Ramscar , Bradley C. Love

Natural language generation (NLG) is a critical component in spoken dialogue systems. Classic NLG can be divided into two phases: (1) sentence planning: deciding on the overall sentence structure, (2) surface realization: determining…

Computation and Language · Computer Science 2018-08-10 Shang-Yu Su , Kai-Ling Lo , Yi-Ting Yeh , Yun-Nung Chen

To simultaneously capture syntax and global semantics from a text corpus, we propose a new larger-context recurrent neural network (RNN) based language model, which extracts recurrent hierarchical semantic structure via a dynamic deep topic…

Computation and Language · Computer Science 2020-06-30 Dandan Guo , Bo Chen , Ruiying Lu , Mingyuan Zhou

Language models have emerged as powerful predictors of the viability of biological sequences. During training these models learn the rules of the grammar obeyed by sequences of amino acids or nucleotides. Once trained, these models can take…

Machine Learning · Computer Science 2025-04-25 Pranav Kantroo , Günter P. Wagner , Benjamin B. Machta

$N$-gram language models (LM) have been largely superseded by neural LMs as the latter exhibits better performance. However, we find that $n$-gram models can achieve satisfactory performance on a large proportion of testing cases,…

Computation and Language · Computer Science 2022-11-04 Huayang Li , Deng Cai , Jin Xu , Taro Watanabe

Tasks related to Natural Language Processing (NLP) have recently been the focus of a large research endeavor by the machine learning community. The increased interest in this area is mainly due to the success of deep learning methods.…

Computation and Language · Computer Science 2020-04-30 Luca Manzoni , Domagoj Jakobovic , Luca Mariot , Stjepan Picek , Mauro Castelli

While end-to-end learning with fully differentiable models has enabled tremendous success in natural language process (NLP) and machine learning, there have been significant recent interests in learning with latent discrete structures to…

Computation and Language · Computer Science 2022-01-12 Zhaofeng Wu

One of the fundamental principles of contemporary linguistics states that language processing requires the ability to extract recursively nested tree structures. However, it remains unclear whether and how this code could be implemented in…

Computation and Language · Computer Science 2021-01-08 Yair Lakretz , Théo Desbordes , Jean-Rémi King , Benoît Crabbé , Maxime Oquab , Stanislas Dehaene

Designing machine intelligence to converse with a human user necessarily requires an understanding of how humans participate in conversation, and thus conversation modeling is an important task in natural language processing. New…

Computation and Language · Computer Science 2023-05-16 Sean Paulsen

Large Language Models (LLMs) possess substantial reasoning capabilities and are increasingly applied to optimization tasks, particularly in synergy with evolutionary computation. However, while recent surveys have explored specific aspects…

Neural and Evolutionary Computing · Computer Science 2026-01-08 Yisong Zhang , Ran Cheng , Guoxing Yi , Kay Chen Tan