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Apparent parallels between natural language and biological sequence have led to a recent surge in the application of deep language models (LMs) to the analysis of antibody and other biological sequences. However, a lack of a rigorous…

Quantitative Methods · Quantitative Biology 2024-08-06 Mai Ha Vu , Philippe A. Robert , Rahmad Akbar , Bartlomiej Swiatczak , Geir Kjetil Sandve , Dag Trygve Truslew Haug , Victor Greiff

Large Language Models (LLMs) are revolutionizing bioinformatics, enabling advanced analysis of DNA, RNA, proteins, and single-cell data. This survey provides a systematic review of recent advancements, focusing on genomic sequence modeling,…

Computation and Language · Computer Science 2026-03-03 Zhenyu Wang , Zikang Wang , Jiyue Jiang , Pengan Chen , Xiangyu Shi , Yu Li

Multilingual transfer ability, which reflects how well models fine-tuned on one source language can be applied to other languages, has been well studied in multilingual pre-trained models. However, the existence of such capability transfer…

Computation and Language · Computer Science 2025-01-20 Wang Liang

The mathematical representation of semantics is a key issue for Natural Language Processing (NLP). A lot of research has been devoted to finding ways of representing the semantics of individual words in vector spaces. Distributional…

Computation and Language · Computer Science 2014-11-13 Karl Moritz Hermann

At the intersection of the rapidly growing biological data landscape and advancements in Natural Language Processing (NLP), protein language models (PLMs) have emerged as a transformative force in modern research. These models have achieved…

Biomolecules · Quantitative Biology 2025-02-12 Lei Wang , Xudong Li , Han Zhang , Jinyi Wang , Dingkang Jiang , Zhidong Xue , Yan Wang

This paper contributes to speeding up the design and deployment of engineering dynamical systems by proposing a strategy for exploiting domain and expert knowledge for the automated generation of a dynamical system computational model…

Computation and Language · Computer Science 2026-04-23 Matthew Anderson Hendricks , Alice Cicirello

Sentence embedding is essential for many NLP tasks, with contrastive learning methods achieving strong performance using annotated datasets like NLI. Yet, the reliance on manual labels limits scalability. Recent studies leverage large…

Computation and Language · Computer Science 2025-06-05 Liyang He , Chenglong Liu , Rui Li , Zhenya Huang , Shulan Ruan , Jun Zhou , Enhong Chen

Our research investigates how Natural Language Processing (NLP) can be used to extract main topics from a larger corpus of written data, as applied to the case of identifying signaling themes in Presidential Directives (PDs) from the Reagan…

Computation and Language · Computer Science 2025-11-14 C. LeMay , A. Lane , J. Seales , M. Winstead , S. Baty

Biological neural networks are shaped both by evolution across generations and by individual learning within an organism's lifetime, whereas standard artificial neural networks undergo a single, large training procedure without inherited…

Machine Learning · Computer Science 2025-05-01 Klemen Kotar , Greta Tuckute

Recent advances in neural network-based generative modeling have reignited the hopes in having computer systems capable of seamlessly conversing with humans and able to understand natural language. Neural architectures have been employed to…

Computation and Language · Computer Science 2020-08-03 Cristina Garbacea , Qiaozhu Mei

Learning algorithms for natural language processing (NLP) tasks traditionally rely on manually defined relevant contextual features. On the other hand, neural network models using an only distributional representation of words have been…

Computation and Language · Computer Science 2017-11-30 Kushal Chawla , Sunil Kumar Sahu , Ashish Anand

Semantic matching is of central importance to many natural language tasks \cite{bordes2014semantic,RetrievalQA}. A successful matching algorithm needs to adequately model the internal structures of language objects and the interaction…

Computation and Language · Computer Science 2015-03-12 Baotian Hu , Zhengdong Lu , Hang Li , Qingcai Chen

The 21st century is presenting humankind with unprecedented environmental and medical challenges. The ability to design novel proteins tailored for specific purposes could transform our ability to respond timely to these issues. Recent…

Biomolecules · Quantitative Biology 2022-08-24 Noelia Ferruz , Birte Höcker

Scientific Large Language Models (Sci-LLMs) have emerged as a promising frontier for accelerating biological discovery. However, these models face a fundamental challenge when processing raw biomolecular sequences: the tokenization dilemma.…

With a focus on natural language processing (NLP) and the role of large language models (LLMs), we explore the intersection of machine learning, deep learning, and artificial intelligence. As artificial intelligence continues to…

Structured reasoning over natural language inputs remains a core challenge in artificial intelligence, as it requires bridging the gap between unstructured linguistic expressions and formal logical representations. In this paper, we propose…

Artificial Intelligence · Computer Science 2025-07-14 Keying Yang , Hao Wang , Kai Yang

Deep Learning methods employ multiple processing layers to learn hierarchial representations of data. They have already been deployed in a humongous number of applications and have produced state-of-the-art results. Recently with the growth…

Computation and Language · Computer Science 2018-08-15 Sarvesh Patil

Understanding whether large language models (LLMs) and the human brain converge on similar computational principles remains a fundamental and important question in cognitive neuroscience and AI. Do the brain-like patterns observed in LLMs…

Computation and Language · Computer Science 2025-12-03 Yu Lei , Xingyang Ge , Yi Zhang , Yiming Yang , Bolei Ma

The exponential growth of data generated on the Internet in the current information age is a driving force for the digital economy. Extraction of information is the major value in an accumulated big data. Big data dependency on statistical…

We propose an alternate approach to quantifying how well language models learn natural language: we ask how well they match the statistical tendencies of natural language. To answer this question, we analyze whether text generated from…

Computation and Language · Computer Science 2021-08-31 Clara Meister , Ryan Cotterell