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The limited ability of Convolutional Neural Networks to generalize to images from previously unseen domains is a major limitation, in particular, for safety-critical clinical tasks such as dermoscopic skin cancer classification. In order to…

Computer Vision and Pattern Recognition · Computer Science 2023-07-04 Katharina Fogelberg , Sireesha Chamarthi , Roman C. Maron , Julia Niebling , Titus J. Brinker

Computational pathology has advanced rapidly in recent years, driven by domain-specific image encoders and growing interest in using vision-language models to answer natural-language questions about diseases. Yet, the core problem behind…

Computer Vision and Pattern Recognition · Computer Science 2026-03-31 Wentao Huang , Weimin Lyu , Peiliang Lou , Qingqiao Hu , Xiaoling Hu , Shahira Abousamra , Wenchao Han , Ruifeng Guo , Jiawei Zhou , Chao Chen , Chen Wang

In pathological research, education, and clinical practice, the decision-making process based on pathological images is critically important. This significance extends to digital pathology image analysis: its adequacy is demonstrated by the…

Image and Video Processing · Electrical Eng. & Systems 2024-08-19 Zhi-Bo Liu , Xiaobo Pang , Jizhao Wang , Shuai Liu , Chen Li

This paper presents a new approach for classifying 2D histopathology patches using few-shot learning. The method is designed to tackle a significant challenge in histopathology, which is the limited availability of labeled data. By applying…

Image and Video Processing · Electrical Eng. & Systems 2024-03-12 Aymen Sadraoui , Ségolène Martin , Eliott Barbot , Astrid Laurent-Bellue , Jean-Christophe Pesquet , Catherine Guettier , Ismail Ben Ayed

Unsupervised domain adaptation (UDA) for nuclei instance segmentation is important for digital pathology, as it alleviates the burden of labor-intensive annotation and domain shift across datasets. In this work, we propose a Cycle…

Computer Vision and Pattern Recognition · Computer Science 2020-05-06 Dongnan Liu , Donghao Zhang , Yang Song , Fan Zhang , Lauren O'Donnell , Heng Huang , Mei Chen , Weidong Cai

In many machine learning domains, datasets are characterized by highly imbalanced and overlapping classes. Particularly in the medical domain, a specific list of symptoms can be labeled as one of various different conditions. Some of these…

Machine Learning · Computer Science 2020-06-03 Ran Ilan Ber , Tom Haramaty

Unsupervised domain adaptation (UDA) aims to transfer and adapt knowledge from a labeled source domain to an unlabeled target domain. Traditionally, subspace-based methods form an important class of solutions to this problem. Despite their…

Machine Learning · Computer Science 2022-01-07 Kowshik Thopalli , Jayaraman J Thiagarajan , Rushil Anirudh , Pavan K Turaga

Annotation scarcity and cross-modality/stain data distribution shifts are two major obstacles hindering the application of deep learning models for nuclei analysis, which holds a broad spectrum of potential applications in digital…

Computer Vision and Pattern Recognition · Computer Science 2024-01-23 Jianan Fan , Dongnan Liu , Hang Chang , Weidong Cai

Deep learning (DL) has been the primary approach used in various computer vision tasks due to its relevant results achieved on many tasks. However, on real-world scenarios with partially or no labeled data, DL methods are also prone to the…

Computer Vision and Pattern Recognition · Computer Science 2022-08-25 Lucas Fernando Alvarenga e Silva , Daniel Carlos Guimarães Pedronette , Fábio Augusto Faria , João Paulo Papa , Jurandy Almeida

Recent advancements in keypoint detection and descriptor extraction have shown impressive performance in local feature learning tasks. However, existing methods generally exhibit suboptimal performance under extreme conditions such as…

Computer Vision and Pattern Recognition · Computer Science 2024-12-10 Jingtai He , Gehao Zhang , Tingting Liu , Songlin Du

In this work, we connect two distinct concepts for unsupervised domain adaptation: feature distribution alignment between domains by utilizing the task-specific decision boundary and the Wasserstein metric. Our proposed sliced Wasserstein…

Computer Vision and Pattern Recognition · Computer Science 2019-03-12 Chen-Yu Lee , Tanmay Batra , Mohammad Haris Baig , Daniel Ulbricht

Recent deep learning frameworks in histopathology, particularly multiple instance learning (MIL) combined with pathology foundational models (PFMs), have shown strong performance. However, PFMs exhibit limitations on certain cancer or…

Solving the domain shift problem during inference is essential in medical imaging, as most deep-learning based solutions suffer from it. In practice, domain shifts are tackled by performing Unsupervised Domain Adaptation (UDA), where a…

Computer Vision and Pattern Recognition · Computer Science 2023-03-14 Vibashan VS , Jeya Maria Jose Valanarasu , Vishal M. Patel

Domain shift is a major problem for deploying deep networks in clinical practice. Network performance drops significantly with (target) images obtained differently than its (source) training data. Due to a lack of target label data, most…

Computer Vision and Pattern Recognition · Computer Science 2020-07-08 Yufan He , Aaron Carass , Lianrui Zuo , Blake E. Dewey , Jerry L. Prince

Domain adaptation algorithms are useful when the distributions of the training and the test data are different. In this paper, we focus on the problem of instrumental variation and time-varying drift in the field of sensors and measurement,…

Computer Vision and Pattern Recognition · Computer Science 2017-06-23 Ke Yan , Lu Kou , David Zhang

The diversity of retinal imaging devices poses a significant challenge: domain shift, which leads to performance degradation when applying the deep learning models trained on one domain to new testing domains. In this paper, we propose a…

Image and Video Processing · Electrical Eng. & Systems 2021-10-07 Peng Liu , Charlie T. Tran , Bin Kong , Ruogu Fang

Utilizing hyperspectral remote sensing technology enables the extraction of fine-grained land cover classes. Typically, satellite or airborne images used for training and testing are acquired from different regions or times, where the same…

Computer Vision and Pattern Recognition · Computer Science 2026-01-29 Yuxiang Zhang , Wei Li , Wen Jia , Mengmeng Zhang , Ran Tao , Shunlin Liang

Histopathological analysis has been transformed by serial section-based methods, advancing beyond traditional 2D histology to enable volumetric and microstructural insights in oncology and inflammatory disease diagnostics. This review…

Tissues and Organs · Quantitative Biology 2025-08-05 Zhenfeng Zhuang , Min Cen , Lei Jiang , Qiong Peng , Yihuang Hu , Hong-Yu Zhou , Liansheng Wang

Preparing and scanning histopathology slides consists of several steps, each with a multitude of parameters. The parameters can vary between pathology labs and within the same lab over time, resulting in significant variability of the…

Computer Vision and Pattern Recognition · Computer Science 2018-01-11 Maxime W. Lafarge , Josien P. W. Pluim , Koen A. J. Eppenhof , Pim Moeskops , Mitko Veta

Histopathology whole slide images (WSIs) are being widely used to develop deep learning-based diagnostic solutions, especially for precision oncology. Most of these diagnostic softwares are vulnerable to biases and impurities in the…

Image and Video Processing · Electrical Eng. & Systems 2024-10-01 Abhijeet Patil , Harsh Diwakar , Jay Sawant , Nikhil Cherian Kurian , Subhash Yadav , Swapnil Rane , Tripti Bameta , Amit Sethi