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Domain shift in the field of histopathological imaging is a common phenomenon due to the intra- and inter-hospital variability of staining and digitization protocols. The implementation of robust models, capable of creating generalized…

Computer Vision and Pattern Recognition · Computer Science 2024-12-06 Ilán Carretero , Pablo Meseguer , Rocío del Amor , Valery Naranjo

Computational analysis of whole slide images (WSIs) has seen significant research progress in recent years, with applications ranging across important diagnostic and prognostic tasks such as survival or cancer subtype prediction. Many…

Computer Vision and Pattern Recognition · Computer Science 2024-11-28 Zak Buzzard , Konstantin Hemker , Nikola Simidjievski , Mateja Jamnik

Precision pathology relies on detecting fine-grained morphological abnormalities within specific Regions of Interest (ROIs), as these local, texture-rich cues - rather than global slide contexts - drive expert diagnostic reasoning. While…

Computer Vision and Pattern Recognition · Computer Science 2026-01-27 Chunze Yang , Wenjie Zhao , Yue Tang , Junbo Lu , Jiusong Ge , Qidong Liu , Zeyu Gao , Chen Li

Histopathology slide digitization introduces scanner-induced domain shift that can significantly impact computational pathology models based on deep learning methods. In the state-of-the-art, this shift is often characterized at a broad…

Learning good representation of giga-pixel level whole slide pathology images (WSI) for downstream tasks is critical. Previous studies employ multiple instance learning (MIL) to represent WSIs as bags of sampled patches because, for most…

Computer Vision and Pattern Recognition · Computer Science 2022-12-01 Chunyuan Li , Xinliang Zhu , Jiawen Yao , Junzhou Huang

Automatic and accurate Gleason grading of histopathology tissue slides is crucial for prostate cancer diagnosis, treatment, and prognosis. Usually, histopathology tissue slides from different institutions show heterogeneous appearances…

Computer Vision and Pattern Recognition · Computer Science 2018-06-08 Jian Ren , Ilker Hacihaliloglu , Eric A. Singer , David J. Foran , Xin Qi

This paper presents a novel approach for unsupervised domain adaptation (UDA) targeting H&E stained histology images. Existing adversarial domain adaptation methods may not effectively align different domains of multimodal distributions…

Computer Vision and Pattern Recognition · Computer Science 2023-10-02 Ravi Kant Gupta , Shounak Das , Amit Sethi

Histopathology is critical for the diagnosis of many diseases, including cancer. These protocols typically require pathologists to manually evaluate slides under a microscope, which is time-consuming and subjective, leading to interest in…

Computer Vision and Pattern Recognition · Computer Science 2023-03-07 Kianoush Falahkheirkhah , Alex Lu , David Alvarez-Melis , Grace Huynh

Objective: We develop a computer-aided diagnosis (CAD) system using deep learning approaches for lesion detection and classification on whole-slide images (WSIs) with breast cancer. The deep features being distinguishing in classification…

Image and Video Processing · Electrical Eng. & Systems 2021-08-29 Wei-Wen Hsu , Yongfang Wu , Chang Hao , Yu-Ling Hou , Xiang Gao , Yun Shao , Xueli Zhang , Tao He , Yanhong Tai

Domain Adaptation is a technique to address the lack of massive amounts of labeled data in unseen environments. Unsupervised domain adaptation is proposed to adapt a model to new modalities using solely labeled source data and unlabeled…

Computer Vision and Pattern Recognition · Computer Science 2021-11-19 Thong Vo , Naimul Khan

In this paper, we address domain shifts in pathological images by focusing on shifts within whole slide images~(WSIs), such as patient characteristics and tissue thickness, rather than shifts between hospitals. Traditional approaches rely…

Computer Vision and Pattern Recognition · Computer Science 2025-08-12 Yuki Shigeyasu , Shota Harada , Akihiko Yoshizawa , Kazuhiro Terada , Naoki Nakazima , Mariyo Kurata , Hiroyuki Abe , Tetsuo Ushiku , Ryoma Bise

Accurate survival prediction from histopathology whole-slide images (WSIs) remains challenging due to their gigapixel resolution, strong spatial heterogeneity, and complex survival distributions. We introduce a comprehensive computational…

Computer Vision and Pattern Recognition · Computer Science 2025-11-18 Ardhendu Sekhar , Vasu Soni , Keshav Aske , Shivam Madnoorkar , Pranav Jeevan , Amit Sethi

Domain shift poses a fundamental challenge in time series analysis, where models trained on source domain often fail dramatically when applied in target domain with different yet similar distributions. While current unsupervised domain…

Machine Learning · Computer Science 2025-08-07 Rongyao Cai , Ming Jin , Qingsong Wen , Kexin Zhang

The development of computational pathology lies in the consensus that pathological characteristics of tumors are significant guidance for cancer diagnostics. Most existing research focuses on the inner-contextual information within each WSI…

Computer Vision and Pattern Recognition · Computer Science 2024-10-15 Jun Shi , Tong Shu , Zhiguo Jiang , Wei Wang , Haibo Wu , Yushan Zheng

The enhanced representational power and broad applicability of deep learning models have attracted significant interest from the research community in recent years. However, these models often struggle to perform effectively under domain…

Computer Vision and Pattern Recognition · Computer Science 2024-12-17 Ba Hung Ngo , Doanh C. Bui , Nhat-Tuong Do-Tran , Tae Jong Choi

The domain shift in pathological segmentation is an important problem, where a network trained by a source domain (collected at a specific hospital) does not work well in the target domain (from different hospitals) due to the different…

Computer Vision and Pattern Recognition · Computer Science 2023-04-27 Xiaoqing Liu , Kengo Araki , Shota Harada , Akihiko Yoshizawa , Kazuhiro Terada , Mariyo Kurata , Naoki Nakajima , Hiroyuki Abe , Tetsuo Ushiku , Ryoma Bise

Domain shift is a significant problem in histopathology. There can be large differences in data characteristics of whole-slide images between medical centers and scanners, making generalization of deep learning to unseen data difficult. To…

Computer Vision and Pattern Recognition · Computer Science 2019-09-27 Karin Stacke , Gabriel Eilertsen , Jonas Unger , Claes Lundström

With the development of digital imaging in medical microscopy, artificial intelligent-based analysis of pathological whole slide images (WSIs) provides a powerful tool for cancer diagnosis. Limited by the expensive cost of pixel-level…

Computer Vision and Pattern Recognition · Computer Science 2024-11-19 Jiawen Li , Qiehe Sun , Renao Yan , Yizhi Wang , Yuqiu Fu , Yani Wei , Tian Guan , Huijuan Shi , Yonghonghe He , Anjia Han

Medical imaging datasets often vary due to differences in acquisition protocols, patient demographics, and imaging devices. These variations in data distribution, known as domain shift, present a significant challenge in adapting imaging…

Computer Vision and Pattern Recognition · Computer Science 2026-03-16 Doron Serebro , Tammy Riklin-Raviv

The rapid digitization of histopathology slides has opened up new possibilities for computational tools in clinical and research workflows. Among these, content-based slide retrieval stands out, enabling pathologists to identify…

Computer Vision and Pattern Recognition · Computer Science 2025-10-28 Hongyi Wang , Zhengjie Zhu , Jiabo Ma , Fang Wang , Yue Shi , Bo Luo , Jili Wang , Qiuyu Cai , Xiuming Zhang , Yen-Wei Chen , Lanfen Lin , Hao Chen
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