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Motivation: Combination therapies have been widely used to treat cancers. However, it is cost- and time-consuming to experimentally screen synergistic drug pairs due to the enormous number of possible drug combinations. Thus, computational…

Quantitative Methods · Quantitative Biology 2020-09-17 Zexuan Sun , Shujun Huang , Peiran Jiang , Pingzhao Hu

Deep learning-based image fusion approaches have obtained wide attention in recent years, achieving promising performance in terms of visual perception. However, the fusion module in the current deep learning-based methods suffers from two…

Computer Vision and Pattern Recognition · Computer Science 2022-02-01 Dongyu Rao , Xiao-Jun Wu , Tianyang Xu , Guoyang Chen

Computational models that accurately predict the binding affinity of an input protein-chemical pair can accelerate drug discovery studies. These models are trained on available protein-chemical interaction datasets, which may contain…

Quantitative Methods · Quantitative Biology 2023-01-10 Rıza Özçelik , Alperen Bağ , Berk Atıl , Melih Barsbey , Arzucan Özgür , Elif Özkırımlı

The drug discovery stage is a vital aspect of the drug development process and forms part of the initial stages of the development pipeline. In recent times, machine learning-based methods are actively being used to model drug-target…

Machine Learning · Computer Science 2020-09-02 Brighter Agyemang , Wei-Ping Wu , Michael Yelpengne Kpiebaareh , Zhihua Lei , Ebenezer Nanor , Lei Chen

Medication Recommendation (MR) is a promising research topic which booms diverse applications in the healthcare and clinical domains. However, existing methods mainly rely on sequential modeling and static graphs for representation…

Machine Learning · Computer Science 2025-01-16 Guanlin Liu , Xiaomei Yu , Zihao Liu , Xue Li , Xingxu Fan , Xiangwei Zheng

We propose a new learning method for heterogeneous domain adaptation (HDA), in which the data from the source domain and the target domain are represented by heterogeneous features with different dimensions. Using two different projection…

Machine Learning · Computer Science 2012-06-22 Lixin Duan , Dong Xu , Ivor Tsang

Person re-identification (re-ID) aims to retrieve the same person across different cameras. In practice, it still remains a challenging task due to background clutter, variations on body poses and view conditions, inaccurate bounding box…

Computer Vision and Pattern Recognition · Computer Science 2020-01-22 Honglong Cai , Yuedong Fang , Zhiguan Wang , Tingchun Yeh , Jinxing Cheng

Current pharmaceutical formulation development still strongly relies on the traditional trial-and-error approach by individual experiences of pharmaceutical scientists, which is laborious, time-consuming and costly. Recently, deep learning…

Machine Learning · Computer Science 2018-12-05 Yilong Yang , Zhuyifan Ye , Yan Su , Qianqian Zhao , Xiaoshan Li , Defang Ouyang

While deep-learning based recommender systems utilizing collaborative filtering have been commonly used for recommendation in other domains, their application in the medical domain have been limited. In addition to modeling user-item…

Information Retrieval · Computer Science 2023-09-19 Aashish Cheruvu

In recent years, current mainstream feature masking distillation methods mainly function by reconstructing selectively masked regions of a student network from the feature maps of a teacher network. In these methods, attention mechanisms…

Computer Vision and Pattern Recognition · Computer Science 2024-07-19 Zhourui Zhang , Jun Li , Zhijian Wu , Jifeng Shen , Jianhua Xu

Recommending safe and effective medication combinations from electronic health records (EHRs) is a core clinical AI problem, yet it remains difficult because patient trajectories are long, noisy, and clinically heterogeneous. Existing…

Machine Learning · Computer Science 2026-05-21 Krati Saxena , Tomohiro Shibata

Recent works on salient object detection have made use of multi-scale features in a way such that high-level features and low-level features can collaborate in locating salient objects. Many of the previous methods have achieved great…

Computer Vision and Pattern Recognition · Computer Science 2022-11-15 Xiaogang Liu Shuang Song

The rapid advancement of deepfake generation techniques poses significant threats to public safety and causes societal harm through the creation of highly realistic synthetic facial media. While existing detection methods demonstrate…

Computer Vision and Pattern Recognition · Computer Science 2026-03-03 Jianfeng Liao , Yichen Wei , Raymond Chan Ching Bon , Shulan Wang , Kam-Pui Chow , Kwok-Yan Lam

Autonomous driving demands accurate perception and safe decision-making. To achieve this, automated vehicles are now equipped with multiple sensors (e.g., camera, Lidar, etc.), enabling them to exploit complementary environmental context by…

Computer Vision and Pattern Recognition · Computer Science 2022-02-24 Xiaoming Zeng , Zhendong Wang , Yang Hu

Drug combination refers to the use of two or more drugs to treat a specific disease at the same time. It is currently the mainstream way to treat complex diseases. Compared with single drugs, drug combinations have better efficacy and can…

Quantitative Methods · Quantitative Biology 2024-10-15 Xinxing Yang , Jiachen Li , Xiao Kang , Guojin Pei , Keyu Liu , Genke Yang , Jian Chu

Background: Discovering potential drug-drug interactions (DDIs) is a long-standing challenge in clinical treatments and drug developments. Recently, deep learning techniques have been developed for DDI prediction. However, they generally…

Machine Learning · Computer Science 2024-03-20 Yaqing Wang , Zaifei Yang , Quanming Yao

High-resolution remote sensing imagery increasingly contains dense clusters of tiny objects, the detection of which is extremely challenging due to severe mutual occlusion and limited pixel footprints. Existing detection methods typically…

Computer Vision and Pattern Recognition · Computer Science 2025-12-30 Zhicheng Zhao , Xuanang Fan , Lingma Sun , Chenglong Li , Jin Tang

Magnetic Resonance Imaging (MRI) is instrumental in clinical diagnosis, offering diverse contrasts that provide comprehensive diagnostic information. However, acquiring multiple MRI contrasts is often constrained by high costs, long…

Computer Vision and Pattern Recognition · Computer Science 2024-09-04 Sanuwani Dayarathna , Kh Tohidul Islam , Bohan Zhuang , Guang Yang , Jianfei Cai , Meng Law , Zhaolin Chen

Drug-drug interaction (DDI) identification is a crucial aspect of pharmacology research. There are many DDI types (hundreds), and they are not evenly distributed with equal chance to occur. Some of the rarely occurred DDI types are often…

Machine Learning · Computer Science 2024-10-17 Liangwei Nathan Zheng , Chang George Dong , Wei Emma Zhang , Xin Chen , Lin Yue , Weitong Chen

Adapting machine learning models to medical time series across different domains remains a challenge due to complex temporal dependencies and dynamic distribution shifts. Current approaches often focus on isolated feature representations,…

Machine Learning · Computer Science 2025-09-23 YongKyung Oh , Alex Bui
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