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Life occurs in concentrated `Ringer Solutions' derived from seawater that Lesser Blum studied for most of his life. As we worked together, Lesser and I realized that the questions asked of those solutions were quite different in biology…

Other Quantitative Biology · Quantitative Biology 2021-09-24 Bob Eisenberg

Artificial neural networks and computational neuroscience models have made tremendous progress, allowing computers to achieve impressive results in artificial intelligence (AI) applications, such as image recognition, natural language…

Neural and Evolutionary Computing · Computer Science 2019-11-05 Giacomo Indiveri , Yulia Sandamirskaya

Since the discovery of the presence of biogenic magnetites in living organisms, there have been speculations on the role that these biomagnetites play in cellular processes. It seems that the formation of biomagnetite crystals is a…

Biological Physics · Physics 2010-12-16 Istvan Bokkon , Vahid Salari

In computer science, we can theoretically neatly separate transmission and processing of information, hardware and software, and programs and their inputs. This is much more intricate in biology, Nevertheless, I argue that Shannon's concept…

Populations and Evolution · Quantitative Biology 2020-11-02 Jürgen Jost

This paper aims to justify the concept of natural intelligence, the type of intelligence wider than human intelligence and its derivative, AI. I will argue that the process of life is a cognitive process and that organisms, from bacteria to…

Other Quantitative Biology · Quantitative Biology 2020-01-07 P Slijepcevic

To explain consciousness as a physical process we must acknowledge the role of energy in the brain. Energetic activity is fundamental to all physical processes and causally drives biological behaviour. Recent neuroscientific evidence can be…

Neurons and Cognition · Quantitative Biology 2018-10-15 Robert Pepperell

Current computers operate at enormous speeds of ~10^13 bits/s, but their principle of sequential logic operation has remained unchanged since the 1950s. Though our brain is much slower on a per-neuron base (~10^3 firings/s), it is capable…

Emerging Technologies · Computer Science 2015-05-30 Anirban Bandyopadhyay , Ranjit Pati , Satyajit Sahu , Ferdinand Peper , Daisuke Fujita

How to artificially encode observer in universal information coding structure like DNA ? It requires naturally creating information Bits and natural encoding triplet code enables recognizing other encoded information. These Bits become…

General Physics · Physics 2019-07-30 Vladimir S. Lerner

Digital life, a form of life generated by computer programs or artificial intelligence systems, it possesses self-awareness, thinking abilities, emotions, and subjective consciousness. Achieving it involves complex neural networks,…

Human-Computer Interaction · Computer Science 2023-10-24 Qikang Zhang

Life is commonly described as a self-organized, far-from-equilibrium process that maintains internal order by consuming free energy and exporting entropy. This thermodynamic view underlies diverse theoretical frameworks -- from autopoiesis…

Biological Physics · Physics 2025-12-23 Didier Sornette , Virgile Troude

Recent advances in nonequilibrium statistical physics have provided unprecedented insight into the thermodynamics of dynamic processes. The author recently used these advances to extend Landauer's semi-formal reasoning concerning the…

Statistical Mechanics · Physics 2016-07-01 David H. Wolpert

In this Chapter, we ask questions (1) What is the right way to measure the quality of information processing in a biological system? and (2) What can real-life organisms do in order to improve their performance in information-processing…

Quantitative Methods · Quantitative Biology 2010-11-25 Ilya Nemenman

The information contained in the genome is insufficient for the control of organism development. Thus, the whereabouts of actual operational directives and workings of the genome remain obscure. In this work, it is suggested that the genome…

Biological Physics · Physics 2007-05-23 S. Y. Berkovich

Cells use biochemical networks to translate environmental information into intracellular responses. These responses can be highly dynamic, but how the information is encoded in these dynamics remains poorly understood. Here we investigate…

Cell Behavior · Quantitative Biology 2017-04-05 Garrett D. Potter , Tommy A. Byrd , Andrew Mugler , Bo Sun

Information is a key concept in evolutionary biology. Information is stored in biological organism's genomes, and used to generate the organism as well as to maintain and control it. Information is also "that which evolves". When a…

Populations and Evolution · Quantitative Biology 2012-07-25 Christoph Adami

It is a fascinating subject to explore how well we can understand the processes of life on the basis of fundamental laws of physics. It is emphasised that viewing biological processes as manipulation of information extracts their essential…

Quantum Physics · Physics 2007-05-23 Apoorva Patel

Living organisms rely on molecular networks, such as gene circuits and signaling pathways, for information processing and robust decision-making in crowded, noisy environments. Recent advances show that interacting biomolecules…

The multifarious internal workings of organisms are difficult to reconcile with a single feature defining a state of being alive. Indeed, definitions of life rely on emergent properties (growth, capacity to evolve, agency) only symptomatic…

Other Quantitative Biology · Quantitative Biology 2023-08-16 Simon Pierce

Many biological functions are executed by molecular machines, which consume energy and convert it into mechanical work. Biological machines have evolved to transport cargo, facilitate folding of proteins and RNA, remodel chromatin and…

Biological Physics · Physics 2020-04-15 Mauro L. Mugnai , Changbong Hyeon , Michael Hinczewski , D. Thirumalai

The idea is advanced that self-organization in complex systems can be treated as decision making (as it is performed by humans) and, vice versa, decision making is nothing but a kind of self-organization in the decision maker nervous…

Adaptation and Self-Organizing Systems · Physics 2014-08-08 V. I. Yukalov , D. Sornette