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Seasonal influenza epidemics cause consistent, considerable, widespread loss annually in terms of economic burden, morbidity, and mortality. With access to accurate and reliable forecasts of a current or upcoming influenza epidemic's…

Populations and Evolution · Quantitative Biology 2016-02-17 Logan C. Brooks , David C. Farrow , Sangwon Hyun , Ryan J. Tibshirani , Roni Rosenfeld

Tracking the spread of infectious disease during a pandemic has posed a great challenge to the governments and health sectors on a global scale. To facilitate informed public health decision-making, the concerned parties usually rely on…

Methodology · Statistics 2023-06-05 Tejasv Bedi , Yanxun Xu , Qiwei Li

To forecast the time dynamics of an epidemic, we propose a discrete stochastic model that unifies and generalizes previous approaches to the subject. Viewing a given population of individuals or groups of individuals with given health state…

The paradigm for compartment models in epidemiology assumes exponentially distributed incubation and removal times, which is not realistic in actual populations. Commonly used variations with multiple exponentially distributed variables are…

Populations and Evolution · Quantitative Biology 2021-02-10 P. Hernández , C. Pena , A. Ramos , J. J. Gómez-Cadenas

Scientific advice to the UK government throughout the COVID-19 pandemic has been informed by ensembles of epidemiological models provided by members of the Scientific Pandemic Influenza group on Modelling (SPI-M). Among other applications,…

Applications · Statistics 2021-08-13 D. S. Silk , V. E. Bowman , D. Semochkina , U. Dalrymple , D. C. Woods

We propose an extension of the classical susceptible infectious recovered (SIR) model that incorporates the effects of spatial propagation of an epidemic through a small number of additional compartments. The model is designed to capture…

Numerical Analysis · Mathematics 2026-03-02 M. Soledad Aronna , Mariana Bergonzi , Ernesto Kofman

Sepsis is a life-threatening condition that seriously endangers millions of people over the world. Hopefully, with the widespread availability of electronic health records (EHR), predictive models that can effectively deal with clinical…

Machine Learning · Computer Science 2019-10-16 Luchen Liu , Haoxian Wu , Zichang Wang , Zequn Liu , Ming Zhang

It is often assumed that events cannot occur simultaneously when modelling data with point processes. This raises a problem as real-world data often contains synchronous observations due to aggregation or rounding, resulting from…

Methodology · Statistics 2021-08-30 Leigh Shlomovich , Edward A. K. Cohen , Niall Adams

A study of changes in the transmission of a disease, in particular, a new disease like COVID-19, requires very flexible models which can capture, among others, the effects of non-pharmacological and pharmacological measures, changes in…

We present the Small-Coupling Dynamic Cavity (SCDC) method, a novel generalized mean-field approximation for epidemic inference and risk assessment within a fully Bayesian framework. SCDC accounts for non-causal effects of observations and…

Disordered Systems and Neural Networks · Physics 2025-05-01 Alfredo Braunstein , Giovanni Catania , Luca Dall'Asta , Matteo Mariani , Fabio Mazza , Mattia Tarabolo

We develop a general modelling framework for compartmental epidemiological systems structured by continuous variables which are linked to the levels of expression of compartment-specific traits. We start by formulating an individual-based…

Populations and Evolution · Quantitative Biology 2025-08-14 Emanuele Bernardi , Tommaso Lorenzi , Mattia Sensi , Andrea Tosin

Assessing the practical identifiability of epidemic models is essential for determining whether parameters can be meaningfully estimated from observed data. Monte Carlo (MC) methods provide an accessible and intuitive framework; however,…

Methodology · Statistics 2025-10-01 Chiara Mattamira , Olivia Prosper Feldman

Stochastic epidemic models can estimate infection and removal rates, and derived quantities such as the basic reproductive number ($R_0$), when both infection and removal times are observed. In practice, however, removal times are often…

Methodology · Statistics 2026-03-24 Seth D. Temple , Jonathan Terhorst

The presence of erratic or unstable paths in standard kinetic Monte Carlo simulations significantly undermines the accurate simulation and sampling of transition pathways. While typically reliable methods, such as the Gillespie algorithm,…

Statistical Mechanics · Physics 2024-12-03 Elad Korngut , Ohad Vilk , Michael Assaf

In this article we focus on dynamic network data which describe interactions among a fixed population through time. We model this data using the latent space framework, in which the probability of a connection forming is expressed as a…

Methodology · Statistics 2021-12-21 Kathryn Turnbull , Christopher Nemeth , Matthew Nunes , Tyler McCormick

We consider a stochastic Susceptible-Exposed-Infected-Recovered (SEIR) epidemiological model with a contact rate that fluctuates seasonally. Through the use of a nonlinear, stochastic projection, we are able to analytically determine the…

Populations and Evolution · Quantitative Biology 2013-09-11 Eric Forgoston , Ira B. Schwartz

Understanding the spread of COVID-19 has been the subject of numerous studies, highlighting the significance of reliable epidemic models. Here, we introduce a novel epidemic model using a latent Hawkes process with temporal covariates for…

Methodology · Statistics 2022-08-16 Stamatina Lamprinakou , Axel Gandy , Emma McCoy

Model comparison for the purposes of selection, averaging and validation is a problem found throughout statistics. Within the Bayesian paradigm, these problems all require the calculation of the posterior probabilities of models within a…

Methodology · Statistics 2015-06-08 Yan Zhou , Adam M Johansen , John A D Aston

Motivated by the recent outbreak of coronavirus (COVID-19), we propose a stochastic model of epidemic temporal growth and mitigation based on a time-modulated Hawkes process. The model is sufficiently rich to incorporate specific…

Populations and Evolution · Quantitative Biology 2021-03-18 Michele Garetto , Emilio Leonardi , Giovanni Luca Torrisi

We apply the cavity master equation (CME) approach to epidemics models. We explore mostly the susceptible-infectious-susceptible (SIS) model, which can be readily treated with the CME as a two-state. We show that this approach is more…

Physics and Society · Physics 2021-03-02 Ernesto Ortega , David Machado , Alejandro Lage-Castellanos