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Large language models (LLMs) have attracted significant attention for potential applications in digital health, while their application in mental health is subject to ongoing debate. This systematic review aims to evaluate the usage of LLMs…

Computers and Society · Computer Science 2024-08-14 Zhijun Guo , Alvina Lai , Johan Hilge Thygesen , Joseph Farrington , Thomas Keen , Kezhi Li

Large language models (LLMs) show promise for clinical use. They are often evaluated using datasets such as MedQA. However, Many medical datasets, such as MedQA, rely on simplified Question-Answering (Q\A) that underrepresents real-world…

Computation and Language · Computer Science 2025-10-24 Yunpeng Xiao , Carl Yang , Mark Mai , Xiao Hu , Kai Shu

Clinical decision-making requires reasoning over incomplete, imprecise, and linguistically expressed patient narratives. While large language models (LLMs) excel at extracting latent information from natural language, they lack the…

Artificial Intelligence · Computer Science 2026-05-26 Xiaoyang Fan , Yufan Cai , Zhe Hou , Jin Song Dong

Large Language Models (LLMs) are increasingly deployed in medicine. However, their utility in non-generative clinical prediction, often presumed inferior to specialized models, remains under-evaluated, leading to ongoing debate within the…

As Large Language Models (LLMs) become widely used to model and simulate human behavior, understanding their biases becomes critical. We developed an experimental framework using Big Five personality surveys and uncovered a previously…

Artificial Intelligence · Computer Science 2024-11-25 Aadesh Salecha , Molly E. Ireland , Shashanka Subrahmanya , João Sedoc , Lyle H. Ungar , Johannes C. Eichstaedt

Large Language Models (LLMs) are increasingly adopted in financial analysis for interpreting complex market data and trends. However, their use is challenged by intrinsic biases (e.g., risk-preference bias) and a superficial understanding…

Computation and Language · Computer Science 2024-07-02 Yuhang Zhou , Yuchen Ni , Yunhui Gan , Zhangyue Yin , Xiang Liu , Jian Zhang , Sen Liu , Xipeng Qiu , Guangnan Ye , Hongfeng Chai

Evaluating long-form answers in high-stakes domains such as law or medicine remains a fundamental challenge. Standard metrics like BLEU and ROUGE fail to capture semantic correctness, and current LLM-based evaluators often reduce nuanced…

Computation and Language · Computer Science 2025-11-04 Fangyi Yu , Nabeel Seedat , Dasha Herrmannova , Frank Schilder , Jonathan Richard Schwarz

Large language models (LLMs) have shown remarkable progress in encoding clinical knowledge and responding to complex medical queries with appropriate clinical reasoning. However, their applicability in subspecialist or complex medical…

Large Language Models (LLMs) are increasingly deployed in high-stakes domains such as clinical decision support and medical documentation. However, the robustness of these models against subtle linguistic variations, specifically…

Computation and Language · Computer Science 2026-05-19 Jen-tse Huang , Didi Zhou , Faith Kamau , Amy Oh , Anne R. Links , Mark Dredze , Mary Catherine Beach , Somnath Saha

Recent advancements in Large Language Models (LLMs) have significantly enhanced their ability to generate and manipulate human language, highlighting their potential across various applications. Evaluating LLMs in languages other than…

Computation and Language · Computer Science 2024-06-26 Fabio Mercorio , Mario Mezzanzanica , Daniele Potertì , Antonio Serino , Andrea Seveso

Large language models (LLMs) are emerging as promising tools for mental health care, offering scalable support through their ability to generate human-like responses. However, the effectiveness of these models in clinical settings remains…

Artificial Intelligence · Computer Science 2024-08-22 Yining Hua , Hongbin Na , Zehan Li , Fenglin Liu , Xiao Fang , David Clifton , John Torous

Large Language Models (LLMs) are expected to significantly contribute to patient care, diagnostics, and administrative processes. Emerging biomedical LLMs aim to address healthcare-specific challenges, including privacy demands and…

Computation and Language · Computer Science 2025-10-14 Amin Dada , Marie Bauer , Amanda Butler Contreras , Osman Alperen Koraş , Constantin Marc Seibold , Kaleb E Smith , Jens Kleesiek

Substance use disorder (SUD) poses a major concern due to its detrimental effects on health and society. SUD identification and treatment depend on a variety of factors such as severity, co-determinants (e.g., withdrawal symptoms), and…

Computation and Language · Computer Science 2024-03-20 Maria Mahbub , Gregory M. Dams , Sudarshan Srinivasan , Caitlin Rizy , Ioana Danciu , Jodie Trafton , Kathryn Knight

Objectives: Compare qualitative coding of instruction tuned large language models (IT-LLMs) against human coders in classifying the presence or absence of vulnerability in routinely collected unstructured text that describes police-public…

Computation and Language · Computer Science 2024-12-17 Sam Relins , Daniel Birks , Charlie Lloyd

Discharge communication is a critical yet underexplored component of patient care, where the goal shifts from diagnosis to education. While recent large language model (LLM) benchmarks emphasize in-visit diagnostic reasoning, they fail to…

Computation and Language · Computer Science 2025-09-22 Zonghai Yao , Michael Sun , Won Seok Jang , Sunjae Kwon , Soie Kwon , Hong Yu

We propose a clinical decision support system (CDSS) for mental health diagnosis that combines the strengths of large language models (LLMs) and constraint logic programming (CLP). Having a CDSS is important because of the high complexity…

Artificial Intelligence · Computer Science 2025-02-24 Brian Hyeongseok Kim , Chao Wang

Trained on a vast amount of data, Large Language models (LLMs) have achieved unprecedented success and generalization in modeling fairly complex textual inputs in the abstract space, making them powerful tools for zero-shot learning. Such…

Computer Vision and Pattern Recognition · Computer Science 2023-05-19 Shervin Ardeshir

Medical question answering (QA) benchmarks often focus on multiple-choice or fact-based tasks, leaving open-ended answers to real patient questions underexplored. This gap is particularly critical in mental health, where patient questions…

Computation and Language · Computer Science 2026-05-15 Yahan Li , Jifan Yao , John Bosco S. Bunyi , Adam C. Frank , Angel Hsing-Chi Hwang , Ruishan Liu

Although large language models (LLMs) have demonstrated their effectiveness in a wide range of applications, they have also been observed to perpetuate unwanted biases present in the training data, potentially leading to harm for…

Computation and Language · Computer Science 2026-03-09 Schrasing Tong , Eliott Zemour , Jessica Lu , Rawisara Lohanimit , Lalana Kagal

The rising prevalence of eye diseases poses a growing public health burden. Large language models (LLMs) offer a promising path to reduce documentation workload and support clinical decision-making. However, few have been tailored for…

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