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Variational auto-encoders (VAEs) are a popular and powerful deep generative model. Previous works on VAEs have assumed a factorized likelihood model, whereby the output uncertainty of each pixel is assumed to be independent. This…

Machine Learning · Statistics 2026-05-14 Gara Dorta , Sara Vicente , Lourdes Agapito , Neill D. F. Campbell , Ivor Simpson

In this paper we demonstrate methods for reliable and efficient training of discrete representation using Vector-Quantized Variational Auto-Encoder models (VQ-VAEs). Discrete latent variable models have been shown to learn nontrivial…

Wastewater-based genomic surveillance has emerged as a powerful tool for population-level viral monitoring, offering comprehensive insights into circulating viral variants across entire communities. However, this approach faces significant…

Machine Learning · Computer Science 2025-12-04 Adele Chinda , Richmond Azumah , Hemanth Demakethepalli Venkateswara

Motivation: Despite advances in the computational analysis of high-throughput molecular profiling assays (e.g. transcriptomics), a dichotomy exists between methods that are simple and interpretable, and ones that are complex but with lower…

Machine Learning · Computer Science 2023-06-12 Pedro Henrique da Costa Avelar , Min Wu , Sophia Tsoka

Variational Autoencoders (VAEs) have been shown to be remarkably effective in recovering model latent spaces for several computer vision tasks. However, currently trained VAEs, for a number of reasons, seem to fall short in learning…

Machine Learning · Computer Science 2021-07-27 Chandrajit Bajaj , Avik Roy , Haoran Zhang

Deep predictive models rely on human supervision in the form of labeled training data. Obtaining large amounts of annotated training data can be expensive and time consuming, and this becomes a critical bottleneck while building such models…

Machine Learning · Statistics 2020-10-01 Bindya Venkatesh , Jayaraman J. Thiagarajan

A new type of experiment that aims to determine the optimal quantities of a sequence of factors is eliciting considerable attention in medical science, bioengineering, and many other disciplines. Such studies require the simultaneous…

Methodology · Statistics 2022-09-14 Qian Xiao , Yaping Wang , Abhyuday Mandal , Xinwei Deng

Variational Autoencoders (VAEs) are essential for large-scale audio tasks like diffusion-based generation. However, existing open-source models often neglect auditory perceptual aspects during training, leading to weaknesses in phase…

Sound · Computer Science 2025-11-07 Kangdi Wang , Zhiyue Wu , Dinghao Zhou , Rui Lin , Junyu Dai , Tao Jiang

The Variational Autoencoder (VAE) is a powerful framework for learning probabilistic latent variable generative models. However, typical assumptions on the approximate posterior distribution of the encoder and/or the prior, seriously…

Machine Learning · Computer Science 2020-07-13 Ifigeneia Apostolopoulou , Elan Rosenfeld , Artur Dubrawski

Due to their unsupervised training and uncertainty estimation, deep Variational Autoencoders (VAEs) have become powerful tools for reconstruction-based Time Series Anomaly Detection (TSAD). Existing VAE-based TSAD methods, either…

Machine Learning · Computer Science 2024-01-09 Zhangkai Wu , Longbing Cao , Qi Zhang , Junxian Zhou , Hui Chen

Self-supervised learning, such as with the wav2vec 2.0 framework significantly improves the accuracy of end-to-end automatic speech recognition (ASR). Wav2vec 2.0 has been applied to single-channel end-to-end ASR models. In this work, we…

Computation and Language · Computer Science 2024-08-07 Atsushi Kojima

Purpose: Handling heterogeneous and mixed data types has become increasingly critical with the exponential growth in real-world databases. While deep generative models attempt to merge diverse data views into a common latent space, they…

Machine Learning · Computer Science 2024-10-23 Alejandro Guerrero-López , Carlos Sevilla-Salcedo , Vanessa Gómez-Verdejo , Pablo M. Olmos

Despite recent successes in synthesizing faces and bedrooms, existing generative models struggle to capture more complex image types, potentially due to the oversimplification of their latent space constructions. To tackle this issue,…

Machine Learning · Computer Science 2018-03-13 Wenling Shang , Kihyuk Sohn , Yuandong Tian

Variational Auto-Encoders (VAEs) are capable of learning latent representations for high dimensional data. However, due to the i.i.d. assumption, VAEs only optimize the singleton variational distributions and fail to account for the…

Machine Learning · Computer Science 2020-04-20 Da Tang , Dawen Liang , Tony Jebara , Nicholas Ruozzi

Computational drug design based on artificial intelligence is an emerging research area. At the time of writing this paper, the world suffers from an outbreak of the coronavirus SARS-CoV-2. A promising way to stop the virus replication is…

Neural and Evolutionary Computing · Computer Science 2020-09-11 Tim Cofala , Lars Elend , Philip Mirbach , Jonas Prellberg , Thomas Teusch , Oliver Kramer

Variational autoencoders (VAEs) are powerful tools for learning latent representations of data used in a wide range of applications. In practice, VAEs usually require multiple training rounds to choose the amount of information the latent…

Machine Learning · Computer Science 2023-08-21 Juhan Bae , Michael R. Zhang , Michael Ruan , Eric Wang , So Hasegawa , Jimmy Ba , Roger Grosse

The chemical space of drug-like molecules is vast, motivating the development of generative models that must learn broad chemical distributions, enable conditional generation by capturing structure-property representations, and provide fast…

We describe a novel weakly supervised deep learning framework that combines both the discriminative and generative models to learn meaningful representation in the multiple instance learning (MIL) setting. MIL is a weakly supervised…

Machine Learning · Computer Science 2018-07-09 Shabnam Ghaffarzadegan

Variational autoencoders (VAE) represent a popular, flexible form of deep generative model that can be stochastically fit to samples from a given random process using an information-theoretic variational bound on the true underlying…

Machine Learning · Computer Science 2019-10-08 Bin Dai , Yu Wang , John Aston , Gang Hua , David Wipf

With the rapid growth of wireless communications, specific emitter identification (SEI) is significant for communication security. However, its model training relies heavily on the large-scale labeled data, which are costly and…

Artificial Intelligence · Computer Science 2026-01-09 Jingyi Wang , Fanggang Wang