English
Related papers

Related papers: PFMBench: Protein Foundation Model Benchmark

200 papers

Foundation model, which is pre-trained on broad data and is able to adapt to a wide range of tasks, is advancing healthcare. It promotes the development of healthcare artificial intelligence (AI) models, breaking the contradiction between…

Computers and Society · Computer Science 2024-04-05 Yuting He , Fuxiang Huang , Xinrui Jiang , Yuxiang Nie , Minghao Wang , Jiguang Wang , Hao Chen

Numerous benchmarks have been established to assess the performance of foundation models on open-ended question answering, which serves as a comprehensive test of a model's ability to understand and generate language in a manner similar to…

Computation and Language · Computer Science 2023-11-07 Yushi Bai , Jiahao Ying , Yixin Cao , Xin Lv , Yuze He , Xiaozhi Wang , Jifan Yu , Kaisheng Zeng , Yijia Xiao , Haozhe Lyu , Jiayin Zhang , Juanzi Li , Lei Hou

Modeling environmental ecosystems is essential for effective resource management, sustainable development, and understanding complex ecological processes. However, traditional methods frequently struggle with the inherent complexity,…

Machine Learning · Computer Science 2025-03-06 Runlong Yu , Shengyu Chen , Yiqun Xie , Xiaowei Jia

The rapid evolution of Multimodal Large Language Models (MLLMs) has brought substantial advancements in artificial intelligence, significantly enhancing the capability to understand and generate multimodal content. While prior studies have…

Artificial Intelligence · Computer Science 2024-09-30 Lin Li , Guikun Chen , Hanrong Shi , Jun Xiao , Long Chen

As the range of applications for Large Language Models (LLMs) continues to grow, the demand for effective serving solutions becomes increasingly critical. Despite the versatility of LLMs, no single model can optimally address all tasks and…

Inverse design of materials has significantly advanced target-driven formulation optimization, yet existing materials machine learning benchmarks remain limited to forward property prediction, failing to systematically evaluate inverse…

Materials Science · Physics 2026-05-27 Linhan Wu , Chenxi Wang , Chuhan Yang , Zhengwei Yang , Yuyang Liu

Computational paralinguistics (ComParal) aims to develop algorithms and models to automatically detect, analyze, and interpret non-verbal information from speech communication, e. g., emotion, health state, age, and gender. Despite its…

We introduce PhysicianBench, a benchmark for evaluating LLM agents on physician tasks grounded in real clinical setting within electronic health record (EHR) environments. Existing medical agent benchmarks primarily focus on static…

Reliable evaluation of AI models is critical for scientific progress and practical application. While existing VLM benchmarks provide general insights into model capabilities, their heterogeneous designs and limited focus on a few imaging…

Computer Vision and Pattern Recognition · Computer Science 2025-02-24 Tim Rädsch , Leon Mayer , Simon Pavicic , A. Emre Kavur , Marcel Knopp , Barış Öztürk , Klaus Maier-Hein , Paul F. Jaeger , Fabian Isensee , Annika Reinke , Lena Maier-Hein

The advances of large foundation models necessitate wide-coverage, low-cost, and zero-contamination benchmarks. Despite continuous exploration of language model evaluations, comprehensive studies on the evaluation of Large Multi-modal…

Computation and Language · Computer Science 2025-09-19 Kaichen Zhang , Bo Li , Peiyuan Zhang , Fanyi Pu , Joshua Adrian Cahyono , Kairui Hu , Shuai Liu , Yuanhan Zhang , Jingkang Yang , Chunyuan Li , Ziwei Liu

Proteins exist as a dynamic ensemble of multiple conformations, and these motions are often crucial for their functions. However, current structure prediction methods predominantly yield a single conformation, overlooking the conformational…

Biomolecules · Quantitative Biology 2025-06-18 Advaith Maddipatla , Nadav Bojan Sellam , Meital Bojan , Sanketh Vedula , Paul Schanda , Ailie Marx , Alex M. Bronstein

Using multimodal foundation models to analyze table images is a high-value yet challenging application in consumer and enterprise scenarios. Despite its importance, current evaluations rely largely on structured-text tables or clean…

Computer Vision and Pattern Recognition · Computer Science 2026-05-25 Junzhe Huang , Xiaoxiao Sun , Yan Yang , Yuxuan Hou , Ruotian Zhang , Sirui Li , Hehe Fan , Serena Yeung-Levy , Xin Yu

With the rapid development of deep learning, training Big Models (BMs) for multiple downstream tasks becomes a popular paradigm. Researchers have achieved various outcomes in the construction of BMs and the BM application in many fields. At…

Composed of amino acid chains that influence how they fold and thus dictating their function and features, proteins are a class of macromolecules that play a central role in major biological processes and are required for the structure,…

Quantitative Methods · Quantitative Biology 2022-07-15 Aaron Wang

Protein language models (PLMs) have shown promise in improving the understanding of protein sequences, contributing to advances in areas such as function prediction and protein engineering. However, training these models from scratch…

Machine Learning · Computer Science 2024-12-19 Shivasankaran Vanaja Pandi , Bharath Ramsundar

We present a new approach for benchmarking Large Language Model (LLM) capabilities on research-level mathematics. Existing benchmarks largely rely on static, hand-curated sets of contest or textbook-style problems as proxies for…

Artificial Intelligence · Computer Science 2026-03-02 Antoine Peyronnet , Fabian Gloeckle , Amaury Hayat

While large vision-language models (VLMs) are increasingly adopted as the perceptual backbone for embodied agents, existing benchmarks often rely on question-answering or multiple-choice formats. These protocols allow models to exploit…

Computer Vision and Pattern Recognition · Computer Science 2026-05-19 Haozhe Shan , Xiancong Ren , Han Dong , Haoyuan Shi , Yingji Zhang , Jiayu Hu , Yi Zhang , Yong Dai , Bin Shen , Lizhen Qu , Zenglin Xu , Xiaozhu Ju

As key elements within the central dogma, DNA, RNA, and proteins play crucial roles in maintaining life by guaranteeing accurate genetic expression and implementation. Although research on these molecules has profoundly impacted fields like…

Large language models (LLMs) have shown potential in assisting scientific research, yet their ability to discover high-quality research hypotheses remains unexamined due to the lack of a dedicated benchmark. To address this gap, we…

Computation and Language · Computer Science 2026-04-21 Yujie Liu , Zonglin Yang , Tong Xie , Jinjie Ni , Ben Gao , Yuqiang Li , Shixiang Tang , Wanli Ouyang , Erik Cambria , Dongzhan Zhou

In this study, we expand upon the FLIP benchmark-designed for evaluating protein fitness prediction models in small, specialized prediction tasks-by assessing the performance of state-of-the-art large protein language models, including…

Machine Learning · Computer Science 2025-01-31 Manuel F. Mollon , Joaquin Gonzalez-Rodriguez , Alicia Lozano-Diez , Daniel Ramos , Doroteo T. Toledano