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Coarse-graining (CG) of molecular simulations simplifies the particle representation by grouping selected atoms into pseudo-beads and drastically accelerates simulation. However, such CG procedure induces information losses, which makes…

Machine Learning · Computer Science 2022-06-20 Wujie Wang , Minkai Xu , Chen Cai , Benjamin Kurt Miller , Tess Smidt , Yusu Wang , Jian Tang , Rafael Gómez-Bombarelli

Reinforcement Learning (RL) has the potential to enable robots to learn from their own actions in the real world. Unfortunately, RL can be prohibitively expensive, in terms of on-robot runtime, due to inefficient exploration when learning…

Structural and thermodynamic consistency of coarse-graining models across multiple length scales is essential for the predictive role of multi-scale modeling and molecular dynamic simulations that use mesoscale descriptions. Our approach is…

Soft Condensed Matter · Physics 2014-07-04 J. McCarty , A. J. Clark , J. Copperman , M. G. Guenza

We introduce the use of reinforcement-learning (RL) techniques to the conformal-bootstrap programme. We demonstrate that suitable soft Actor-Critic RL algorithms can perform efficient, relatively cheap high-dimensional searches in the space…

High Energy Physics - Theory · Physics 2022-02-02 Gergely Kántor , Vasilis Niarchos , Constantinos Papageorgakis

The prevailing graph neural network models have achieved significant progress in graph representation learning. However, in this paper, we uncover an ever-overlooked phenomenon: the pre-trained graph representation learning model tested…

Machine Learning · Computer Science 2023-02-14 Hang Gao , Jiangmeng Li , Wenwen Qiang , Lingyu Si , Bing Xu , Changwen Zheng , Fuchun Sun

Model-based compression is an effective, facilitating, and expanded model of neural network models with limited computing and low power. However, conventional models of compression techniques utilize crafted features [2,3,12] and explore…

Machine Learning · Statistics 2018-07-10 Hamed Hakkak

Causal representation learning (CRL) aims to identify the underlying latent variables from high-dimensional observations, even when variables are dependent with each other. We study this problem for latent variables that follow a…

Machine Learning · Statistics 2026-04-16 Danru Xu , Sébastien Lachapelle , Sara Magliacane

Sparse autoencoders (SAEs) decompose language model activations into interpretable features, but existing methods reveal only which features activate, not which change model outputs when amplified. We introduce Control Reinforcement…

Machine Learning · Computer Science 2026-05-05 Seonglae Cho , Zekun Wu , Adriano Koshiyama

Constrained Reinforcement Learning (CRL) aims to optimize decision-making policies under constraint conditions, making it highly applicable to safety-critical domains such as autonomous driving, robotics, and power grid management. However,…

Machine Learning · Computer Science 2026-02-16 Wentao Xu , Zhongming Yao , Weihao Li , Zhenghang Song , Yumeng Song , Tianyi Li , Yushuai Li

Short-fiber-reinforced polymer composites are increasingly used in engineering applications and industrial products owing to their unique combination of superior mechanical properties, and relatively easy and low cost manufacturing process.…

Applied Physics · Physics 2017-04-25 Behrouz Arash , Harold S. Park , Timon Rabczuk

The aim of the inverse chemical design is to develop new molecules with given optimized molecular properties or objectives. Recently, generative deep learning (DL) networks are considered as the state-of-the-art in inverse chemical design…

Machine Learning · Computer Science 2019-10-10 Haoran Wei , Mariefel Olarte , Garrett B. Goh

We present a panoramic view of the utility of coarse-grained (CG) models to study folding and functions of proteins and RNA. Drawing largely on the methods developed in our group over the last twenty years, we describe a number of key…

Biomolecules · Quantitative Biology 2008-08-25 D. L. Pincus , S. S. Cho , C. Hyeon , D. Thirumalai

Recent advances in text-conditioned image generation diffusion models have begun paving the way for new opportunities in modern medical domain, in particular, generating Chest X-rays (CXRs) from diagnostic reports. Nonetheless, to further…

Computer Vision and Pattern Recognition · Computer Science 2024-03-12 Woojung Han , Chanyoung Kim , Dayun Ju , Yumin Shim , Seong Jae Hwang

The ability to prepare a physical system in a desired quantum state is central to many areas of physics such as nuclear magnetic resonance, cold atoms, and quantum computing. Yet, preparing states quickly and with high fidelity remains a…

Deep learning (DL) is an emerging analysis tool across sciences and engineering. Encouraged by the successes of DL in revealing quantitative trends in massive imaging data, we applied this approach to nano-scale deeply sub-diffractional…

Segmentation of nanoscale electron microscopy (EM) images is crucial but still challenging in connectomics research. One reason for this is that none of the existing segmentation methods are error-free, so they require proofreading, which…

Computer Vision and Pattern Recognition · Computer Science 2022-03-14 Khoa Tuan Nguyen , Ganghee Jang , Tran Anh Tuan , Won-ki Jeong

The advent of promising quantum error correction (QEC) codes with efficient resource utilization and high-performance fault-tolerant quantum memories signifies a critical step towards realizing practical quantum computation. While surface…

Quantum Physics · Physics 2026-01-28 Yidong Zhou , Lingyi Kong , Yifeng Peng , Zhiding Liang

In the context of online education, designing an automatic solver for geometric problems has been considered a crucial step towards general math Artificial Intelligence (AI), empowered by natural language understanding and traditional…

Computers and Society · Computer Science 2024-03-25 Xiuqin Zhong , Shengyuan Yan , Gongqi Lin , Hongguang Fu , Liang Xu , Siwen Jiang , Lei Huang , Wei Fang

We develop a renormalization group (RG) procedure that includes important system-specific features. The key ingredient is to systematize the coarse graining procedure that generates the RG flow. The coarse graining technology comes from…

Statistical Mechanics · Physics 2015-05-13 David E. Reynolds

While a diverse collection of continual learning (CL) methods has been proposed to prevent catastrophic forgetting, a thorough investigation of their effectiveness for processing sequential data with recurrent neural networks (RNNs) is…

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