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We propose a fluid-based registration framework of medical images based on implicit neural representation. By integrating implicit neural representation and Large Deformable Diffeomorphic Metric Mapping (LDDMM), we employ a Multilayer…

Image and Video Processing · Electrical Eng. & Systems 2023-11-28 Chulong Zhang , Xiaokun Liang

In this work, we introduce Brain Latent Progression (BrLP), a novel spatiotemporal disease progression model based on latent diffusion. BrLP is designed to predict the evolution of diseases at the individual level on 3D brain MRIs. Existing…

Computer Vision and Pattern Recognition · Computer Science 2025-07-15 Lemuel Puglisi , Daniel C. Alexander , Daniele Ravì

Despite the ever-increasing interest in applying deep learning (DL) models to medical imaging, the typical scarcity and imbalance of medical datasets can severely impact the performance of DL models. The generation of synthetic data that…

Image and Video Processing · Electrical Eng. & Systems 2023-04-03 Pouria Rouzrokh , Bardia Khosravi , Shahriar Faghani , Mana Moassefi , Sanaz Vahdati , Bradley J. Erickson

Accurately identifying oocytes that progress to the blastocyst stage is crucial in reproductive medicine, but the limited availability of annotated high-quality embryo images presents challenges for developing automated diagnostic tools. To…

Quantitative Methods · Quantitative Biology 2025-06-18 Alejandro Golfe , Natalia P. García-de-la-puente , Adrián Colomer , Valery Naranjo

Deep learning methods based on Convolutional Neural Networks (CNNs) have shown great potential to improve early and accurate diagnosis of Alzheimer's disease (AD) dementia based on imaging data. However, these methods have yet to be widely…

Computer Vision and Pattern Recognition · Computer Science 2025-01-22 Wenjie Kang , Lize Jiskoot , Peter De Deyn , Geert Biessels , Huiberdina Koek , Jurgen Claassen , Huub Middelkoop , Wiesje Flier , Willemijn J. Jansen , Stefan Klein , Esther Bron

Understanding the interactions between biomarkers among brain regions during neurodegenerative disease is essential for unravelling the mechanisms underlying disease progression. For example, pathophysiological models of Alzheimer's Disease…

Artificial Intelligence · Computer Science 2025-11-17 Tiantian He , An Zhao , Elinor Thompson , Anna Schroder , Ahmed Abdulaal , Frederik Barkhof , Daniel C. Alexander

Accurate detection and segmentation of brain tumors from magnetic resonance imaging (MRI) are essential for diagnosis, treatment planning, and clinical monitoring. While convolutional architectures such as U-Net have long been the backbone…

Computer Vision and Pattern Recognition · Computer Science 2025-10-03 Arman Behnam

Recent 3D human generative models have achieved remarkable progress by learning 3D-aware GANs from 2D images. However, existing 3D human generative methods model humans in a compact 1D latent space, ignoring the articulated structure and…

Computer Vision and Pattern Recognition · Computer Science 2024-07-03 Tao Hu , Fangzhou Hong , Ziwei Liu

Mammography is the most commonly used imaging modality for breast cancer screening, driving an increasing demand for deep-learning techniques to support large-scale analysis. However, the development of accurate and robust methods is often…

Image and Video Processing · Electrical Eng. & Systems 2025-07-28 Xin Li , Kaixiang Yang , Qiang Li , Zhiwei Wang

Temporal volume images with 3D+t (4D) information are often used in medical imaging to statistically analyze temporal dynamics or capture disease progression. Although deep-learning-based generative models for natural images have been…

Image and Video Processing · Electrical Eng. & Systems 2022-06-28 Boah Kim , Jong Chul Ye

Time series generation is a crucial research topic in the area of decision-making systems, which can be particularly important in domains like autonomous driving, healthcare, and, notably, robotics. Recent approaches focus on learning in…

Machine Learning · Computer Science 2024-09-16 Jian Qian , Bingyu Xie , Biao Wan , Minhao Li , Miao Sun , Patrick Yin Chiang

The most advanced diffusion models have recently adopted increasingly deep stacked networks (e.g., U-Net or Transformer) to promote the generative emergence capabilities of vision generation models similar to large language models (LLMs).…

Computer Vision and Pattern Recognition · Computer Science 2024-07-23 Zhiyuan Ma , Liangliang Zhao , Biqing Qi , Bowen Zhou

Breast-Conserving Surgery (BCS) requires precise intraoperative margin assessment to preserve healthy tissue. Deep Ultraviolet Fluorescence Scanning Microscopy (DUV-FSM) offers rapid, high-resolution surface imaging for this purpose;…

Computer Vision and Pattern Recognition · Computer Science 2026-01-27 Pouya Afshin , David Helminiak , Tianling Niu , Julie M. Jorns , Tina Yen , Bing Yu , Dong Hye Ye

Generating molecular structures with desired properties is a critical task with broad applications in drug discovery and materials design. We propose 3M-Diffusion, a novel multi-modal molecular graph generation method, to generate diverse,…

Machine Learning · Computer Science 2024-10-04 Huaisheng Zhu , Teng Xiao , Vasant G Honavar

Advances in neuroscience and artificial intelligence have enabled preliminary decoding of brain activity. However, despite the progress, the interpretability of neural representations remains limited. A significant challenge arises from the…

Computer Vision and Pattern Recognition · Computer Science 2025-12-23 Hasib Aslam , Muhammad Talal Faiz , Muhammad Imran Malik

Latent diffusion models (LDMs) enable high-fidelity synthesis by operating in learned latent spaces. However, training state-of-the-art LDMs requires complex staging: a tokenizer must be trained first, before the diffusion model can be…

Computer Vision and Pattern Recognition · Computer Science 2026-03-24 Shivam Duggal , Xingjian Bai , Zongze Wu , Richard Zhang , Eli Shechtman , Antonio Torralba , Phillip Isola , William T. Freeman

Magnetic Resonance (MR) imaging plays an essential role in contemporary clinical diagnostics. It is increasingly integrated into advanced therapeutic workflows, such as hybrid Positron Emission Tomography/Magnetic Resonance (PET/MR) imaging…

Image and Video Processing · Electrical Eng. & Systems 2025-07-17 Jiaxu Zheng , Meiman He , Xuhui Tang , Xiong Wang , Tuoyu Cao , Tianyi Zeng , Lichi Zhang , Chenyu You

Alzheimers disease progresses slowly and involves complex interaction between various biological factors. Longitudinal medical imaging data can capture this progression over time. However, longitudinal data frequently encounter issues such…

Computer Vision and Pattern Recognition · Computer Science 2024-11-12 Duy-Phuong Dao , Hyung-Jeong Yang , Jahae Kim

Diffusion generative models have emerged as a powerful framework for addressing problems in structural biology and structure-based drug design. These models operate directly on 3D molecular structures. Due to the unfavorable scaling of…

Biomolecules · Quantitative Biology 2024-05-10 Ian Dunn , David Ryan Koes

Diffusion priors have been used for blind face restoration (BFR) by fine-tuning diffusion models (DMs) on restoration datasets to recover low-quality images. However, the naive application of DMs presents several key limitations. (i) The…

Computer Vision and Pattern Recognition · Computer Science 2025-03-25 Senmao Li , Kai Wang , Joost van de Weijer , Fahad Shahbaz Khan , Chun-Le Guo , Shiqi Yang , Yaxing Wang , Jian Yang , Ming-Ming Cheng
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