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The combined growth of available data and their unstructured nature has received increased interest in natural language processing (NLP) techniques to make value of these data assets since this format is not suitable for statistical…

Computation and Language · Computer Science 2023-04-07 Vitor Alcantara Batista , Alexandre Gonçalves Evsukoff

Large-scale clinical data is invaluable to driving many computational scientific advances today. However, understandable concerns regarding patient privacy hinder the open dissemination of such data and give rise to suboptimal siloed…

Computation and Language · Computer Science 2019-05-23 Oren Melamud , Chaitanya Shivade

Clinicians often need to retrieve patient-specific information from electronic health records (EHRs), a task that is time-consuming and error-prone. We present a locally deployable Clinical Contextual Question Answering (CCQA) framework…

Computation and Language · Computer Science 2026-03-30 Mikko Saukkoriipi , Nicole Hernandez , Jaakko Sahlsten , Kimmo Kaski , Otso Arponen

Large Language Models (LLMs) have recently demonstrated remarkable performance in tasks such as Retrieval-Augmented Generation (RAG) and autonomous AI agent workflows. Yet, when faced with large sets of unstructured documents requiring…

Databases · Computer Science 2025-02-25 Longbin Lai , Changwei Luo , Yunkai Lou , Mingchen Ju , Zhengyi Yang

Clinical notes are an efficient way to record patient information but are notoriously hard to decipher for non-experts. Automatically simplifying medical text can empower patients with valuable information about their health, while saving…

Extraction of concepts present in patient clinical records is an essential step in clinical research. The 2010 i2b2/VA Workshop on Natural Language Processing Challenges for clinical records presented concept extraction (CE) task, with aim…

Computation and Language · Computer Science 2016-10-20 Raghavendra Chalapathy , Ehsan Zare Borzeshi , Massimo Piccardi

Research is a tertiary priority in the EHR, where the priorities are patient care and billing. Because of this, the data is not standardized or formatted in a manner easily adapted to machine learning approaches. Data may be missing for a…

Machine Learning · Computer Science 2017-07-25 Brett K. Beaulieu-Jones

Structured learning is appropriate when predicting structured outputs such as trees, graphs, or sequences. Most prior work requires the training set to consist of complete trees, graphs or sequences. Specifying such detailed ground truth…

Machine Learning · Computer Science 2012-07-03 Xinghua Lou , Fred Hamprecht

Predicting disease trajectories from electronic health records (EHRs) is a complex task due to major challenges such as data non-stationarity, high granularity of medical codes, and integration of multimodal data. EHRs contain both…

Machine Learning · Computer Science 2025-02-26 Sifal Klioui , Sana Sellami , Youssef Trardi

Widespread adoption of electronic health records (EHRs) has fueled the development of using machine learning to build prediction models for various clinical outcomes. This process is often constrained by having a relatively small number of…

Computation and Language · Computer Science 2020-05-14 Ethan Steinberg , Ken Jung , Jason A. Fries , Conor K. Corbin , Stephen R. Pfohl , Nigam H. Shah

We introduce SoftTiger, a clinical large language model (CLaM) designed as a foundation model for healthcare workflows. The narrative and unstructured nature of clinical notes is a major obstacle for healthcare intelligentization. We…

Computation and Language · Computer Science 2024-08-21 Ye Chen , Igor Couto , Wei Cai , Cong Fu , Bruno Dorneles

The proliferation of Large Language Models (LLMs) has led to a burgeoning ecosystem of specialized, domain-specific models. While this rapid growth accelerates innovation, it has simultaneously created significant challenges in model…

Software Engineering · Computer Science 2026-04-16 Pengyue Yang , Haolin Jin , Qingwen Zeng , Jiawen Wen , Harry Rao , Huaming Chen

Deep learning models for pulmonary disease screening from Computed Tomography (CT) scans promise to alleviate the immense workload on radiologists. Still, their high computational cost, stemming from processing entire 3D volumes, remains a…

Image and Video Processing · Electrical Eng. & Systems 2026-03-19 Qian Shao , Bang Du , Yixuan Wu , Zepeng Li , Qiyuan Chen , Qianqian Tang , Jian Wu , Jintai Chen , Hongxia Xu

Automatic extraction of clinical concepts is an essential step for turning the unstructured data within a clinical note into structured and actionable information. In this work, we propose a clinical concept extraction model for automatic…

Computation and Language · Computer Science 2018-11-28 Henghui Zhu , Ioannis Ch. Paschalidis , Amir Tahmasebi

The practice of fine-tuning Pre-trained Language Models (PLMs) from general or domain-specific data to a specific task with limited resources, has gained popularity within the field of natural language processing (NLP). In this work, we…

Computation and Language · Computer Science 2023-10-31 Samuel Belkadi , Lifeng Han , Yuping Wu , Goran Nenadic

Rare diseases pose significant challenges in diagnosis and treatment due to their low prevalence and heterogeneous clinical presentations. Unstructured clinical notes contain valuable information for identifying rare diseases, but manual…

Computation and Language · Computer Science 2024-11-12 Jinge Wu , Hang Dong , Zexi Li , Haowei Wang , Runci Li , Arijit Patra , Chengliang Dai , Waqar Ali , Phil Scordis , Honghan Wu

Metadata play a crucial role in ensuring the findability, accessibility, interoperability, and reusability of datasets. This paper investigates the potential of large language models (LLMs), specifically GPT-4, to improve adherence to…

Artificial Intelligence · Computer Science 2025-02-24 Sowmya S. Sundaram , Benjamin Solomon , Avani Khatri , Anisha Laumas , Purvesh Khatri , Mark A. Musen

Radiology reports are critical for clinical decision-making but often lack a standardized format, limiting both human interpretability and machine learning (ML) applications. While large language models (LLMs) have shown strong capabilities…

Computation and Language · Computer Science 2025-07-15 Johannes Moll , Louisa Fay , Asfandyar Azhar , Sophie Ostmeier , Tim Lueth , Sergios Gatidis , Curtis Langlotz , Jean-Benoit Delbrouck

Large Language Models (LLMs) have emerged as transformative tools in the healthcare sector, demonstrating remarkable capabilities in natural language understanding and generation. However, their proficiency in numerical reasoning,…

Artificial Intelligence · Computer Science 2025-01-27 Arjun R. Malghan

Use of medical data, also known as electronic health records, in research helps develop and advance medical science. However, protecting patient confidentiality and identity while using medical data for analysis is crucial. Medical data can…

Artificial Intelligence · Computer Science 2018-10-17 Vithya Yogarajan , Michael Mayo , Bernhard Pfahringer