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From the complex motions of robots to the oxygen binding of hemoglobin, the function of many mechanical systems depends on large, coordinated movements of their components. Such movements arise from a network of physical interactions in the…

Soft Condensed Matter · Physics 2019-06-21 Jason Z. Kim , Zhixin Lu , Danielle S. Bassett

Multi-step pathways, constituted of a sequence of reconfigurations, are central to a wide variety of natural and man-made systems. Such pathways autonomously execute in self-guided processes such as protein folding and self-assembly, but…

Soft Condensed Matter · Physics 2018-10-18 Corentin Coulais , Alberico Sabbadini , Fré Vink , Martin van Hecke

Mesoscale molecular assemblies on the cell surface, such as cilia and filopodia, integrate information, control transport and amplify signals. Synthetic devices mimicking these structures could sensitively monitor these cellular functions…

We demonstrate hierarchical assembly of plasmonic toroidal metamolecules, which exhibit tailored optical activity in the visible spectral range. Each metamolecule consists of four identical origami-templated helical building blocks. Such…

DNA nanoparticles with three-fold coordination have been observed to self-assemble in experiment into a network equivalent to the hexagonal (6.6.6) tiling, and a network equivalent to the 4.8.8 Archimedean tiling. Both networks are built…

Statistical Mechanics · Physics 2018-05-28 Zdenek Preisler , Barbara Sacca , Stephen Whitelam

Biological cells in living tissues form dynamic patterns with local orientational order and topological defects. Here we demonstrate an approach to produce cell monolayer with the predesigned orientational patterns using human dermal…

The specificity and thermal reversibility of DNA interactions have enabled the self-assembly of crystal structures, self-replicating materials and colloidal molecules. Grafting DNA onto liquid interfaces of emulsions leads to exciting new…

Soft Condensed Matter · Physics 2013-10-31 Lang Feng , Lea-Laetitia Pontani , Remi Dreyfus , Paul Chaikin , Jasna Brujic

The rapid development of the DNA nanotechnology field has been facilitated by advances in CAD software. However, as more complex concepts arose, the lag between the needs and software capabilities appeared. Further derailed by manual…

Quantitative Methods · Quantitative Biology 2021-11-30 Samson Petrosyan , Grigory Tikhomirov

We present Brownian dynamics simulations of the facilitated diffusion of a protein, modelled as a sphere with a binding site on its surface, along DNA, modelled as a semi-flexible polymer. We consider both the effect of DNA organisation in…

Biological Physics · Physics 2012-12-10 C. A. Brackley , M. E. Cates , D. Marenduzzo

DNA origami nanostructures provide programmable control over nanoscale geometry but remain challenging to image due to their low atomic number. Here, we systematically evaluate imaging strategies for both stained and unstained DNA origami…

Biology is full of intricate molecular structures whose geometries are inextricably linked to their function. Many of these structures exhibit varying curvature, such as the helical structure of the bacterial flagellum, which is critical…

The challenge in reconfigurable manipulation of sound waves using metasurfaces lies in achieving precise control over acoustic behavior while developing efficient and practical tuning methods for structural configurations. However, most…

Natural filaments, such as proteins, plant tendrils, octopus tentacles, and elephant trunks, can transform into arbitrary three-dimensional shapes that carry out vital functions. Their shape-morphing behavior arises from intricate…

Fabricating nanocavities in which optically-active single quantum emitters are precisely positioned, is crucial for building nanophotonic devices. Here we show that self-assembly based on robust DNA-origami constructs can precisely position…

Biological membranes are shaped by various proteins that either generate inward or outward membrane curvature. In this article, we investigate the membrane morphologies induced by mixtures of arc-shaped particles with coarse-grained…

Subcellular Processes · Quantitative Biology 2020-04-03 Francesco Bonazzi , Carol K. Hall , Thomas R. Weikl

We consider a three-dimensional network of aqueous droplets joined by single lipid bilayers to form a cohesive, tissue-like material. The droplets in these networks can be programmed to have distinct osmolarities so that osmotic gradients…

Soft Condensed Matter · Physics 2016-03-23 T. Zhang , Duanduan Wan , J. M. Schwarz , M. J. Bowick

Cholesterol plays an essential role in biological membranes and is crucial for maintaining their stability and functionality. It is necessary for a variety of membranes, including planar bilayers, liposomes, curved bilayers, nanodiscs, and…

Biomolecules · Quantitative Biology 2025-04-09 Ehsaneh Khodadadi , Ehsan Khodadadi , Parth Chaturvedi , Mahmoud Moradi

Advances in DNA nanotechnology have stimulated the search for simple motifs that can be used to control the properties of DNA nanostructures. One such motif, which has been used extensively in structures such as polyhedral cages,…

Soft Condensed Matter · Physics 2015-06-10 John S. Schreck , Thomas E. Ouldridge , Flavio Romano , Ard A. Louis , Jonathan P. K. Doye

Biological membranes constitute boundaries of cells and cell organelles. Physico-chemical mechanisms at the atomic scale are dictated by protein-lipid interaction strength, lipid composition, lipid distribution in the vicinity of the…

Biological Physics · Physics 2015-10-19 N. Ramakrishnan , P. B. Sunil Kumar , Ravi Radhakrishnan

Two-dimensional photonic crystal membranes provide a versatile planar architecture for integrated photonics to control the propagation of light on a chip employing high quality optical cavities, waveguides, beamsplitters or dispersive…