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Nucleosomes organize the folding of DNA into chromatin and significantly influence transcription, replication, regulation and repair. All atom molecular dynamics simulations of a nucleosome and of its 146 basepairs of DNA free in solution…

Biomolecules · Quantitative Biology 2007-05-23 Thomas C. Bishop

Flow-driven rotary motors drive functional processes in human society such as windmills and water wheels. Although examples of such rotary motors also feature prominently in cell biology, their synthetic construction at the nanoscale has…

Origami structures often serve as the building block of mechanical systems due to their rich static and dynamic behaviors. Experimental observation and theoretical modeling of origami dynamics have been reported extensively, whereas the…

Dynamical Systems · Mathematics 2023-03-09 Shuaifeng Li , Yasuhiro Miyazawa , Koshiro Yamaguchi , Panayotis G. Kevrekidis , Jinkyu Yang

Based on a recently proposed non-equilibrium mechanism for spatial pattern formation [cond-mat/0312366] we study how morphogenesis can be controlled by locally coupled discrete dynamical networks, similar to gene regulation networks of…

Molecular Networks · Quantitative Biology 2007-05-23 Thimo Rohlf , Stefan Bornholdt

Soft robotics gripper have shown great promise in handling fragile and geometrically complex objects. However, most existing solutions rely on bulky actuators, complex control strategies, or advanced tactile sensing to achieve stable and…

Robotics · Computer Science 2025-11-04 Peiyi Wang , Paul A. M. Lefeuvre , Shangwei Zou , Zhenwei Ni , Daniela Rus , Cecilia Laschi

Mechanically interlocked molecules have marked a breakthrough in the field of topological chemistry and boosted the vigorous development of molecular machinery. As an archetypal example of the interlocked molecules, catenanes comprise…

Biological Physics · Physics 2021-05-03 Andreas Peil , Pengfei Zhan , Na Liu

Molecular topology of polymers plays a key role in determining their physical properties. We studied herein the topological effects on the static and dynamic properties of a 2D catenated network of DNA rings called a kinetoplast.…

Soft Condensed Matter · Physics 2022-09-13 Indresh Yadav , Dana Al Sulaiman , Patrick S. Doyle

The self-assembly of complex structures from engineered subunits is a major goal of nanotechnology, but controlling their size becomes increasingly difficult in larger assemblies. Existing strategies present significant challenges, among…

Multitask Reinforcement Learning is a promising way to obtain models with better performance, generalisation, data efficiency, and robustness. Most existing work is limited to compatible settings, where the state and action space dimensions…

Machine Learning · Computer Science 2021-04-15 Vitaly Kurin , Maximilian Igl , Tim Rocktäschel , Wendelin Boehmer , Shimon Whiteson

Adaptation to various scene configurations and object properties, stability and dexterity in robotic grasping manipulation is far from explored. This work presents an origami-based shape morphing fingertip design to actively tackle the…

Robotics · Computer Science 2020-10-13 Zicheng Kan , Yazhan Zhang , Chohei Pang , Michael Yu Wang

DNA-mediated computing is a novel technology that seeks to capitalize on the enormous informational capacity of DNA and has tremendous computational ability to compete with the current silicon-mediated computing, due to massive parallelism…

Emerging Technologies · Computer Science 2017-09-01 Jian-Jun Shu , Qi-Wen Wang , Kian-Yan Yong

Lipid membranes, the barrier defining living cells and many of their sub-compartments, bind to a wide variety of nano- and micro-meter sized objects. In the presence of strong adhesive forces, membranes can strongly deform and wrap the…

Synthesis of DNA molecules offers unprecedented advances in storage technology. Yet, the microscopic world in which these molecules reside induces error patterns that are fundamentally different from their digital counterparts. Hence, to…

Information Theory · Computer Science 2017-08-08 Netanel Raviv , Moshe Schwartz , Eitan Yaakobi

Lipid bilayers often form high-curvature configurations due to self-assembly conditions or certain biological processes. However, particle-based simulations of lipid membranes are predominantly of flat lipid membranes because planar…

Soft Condensed Matter · Physics 2025-01-31 James Tallman , Antonia Statt

In living cells, membrane morphology is regulated by various proteins. Many membrane reshaping proteins contain a Bin/Amphiphysin/Rvs (BAR) domain, which consists of a banana-shaped rod. The BAR domain bends the biomembrane along the rod…

Soft Condensed Matter · Physics 2016-02-15 Hiroshi Noguchi

Laser-based manufacturing has emerged as a promising alternative to conventional thermal and mechanical processing owing to its precision, versatility, and ability to work across diverse materials. In particular, tailoring the spatial…

Kirigami-inspired metamaterials are attracting increasing interest because of their ability to achieve extremely large strains and shape changes via out-of-plane buckling. While in flat kirigami sheets the ligaments buckle simultaneously as…

Soft Condensed Matter · Physics 2019-05-02 Ahmad Rafsanjani , Lishuai Jin , Bolei Deng , Katia Bertoldi

DNA nanostar (DNAns) hydrogels are promising materials for in vivo applications, including tissue regeneration and drug and antibody delivery. However, a systematic and quantitative understanding of the design principles controlling their…

Self-assembly is one of the most promising strategies for making functional materials at the nanoscale, yet new design principles for making self-limiting architectures, rather than spatially unlimited periodic lattice structures, are…

DNA self-assembly is an important tool that has a wide range of applications such as building nanostructures, the transport of target virotherapies, and nano-circuitry. Tools from graph theory can be used to encode the biological process of…

Combinatorics · Mathematics 2023-10-09 Cory Johnson , Andrew Lavengood-Ryan
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