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The applications of large language models (LLMs) are promising for biomedical and healthcare research. Despite the availability of open-source LLMs trained using a wide range of biomedical data, current research on the applications of LLMs…

Machine Learning · Computer Science 2024-09-25 Tianyu Liu , Yijia Xiao , Xiao Luo , Hua Xu , W. Jim Zheng , Hongyu Zhao

Large Language Models (LLMs) have revolutionized natural language processing through their state of art reasoning capabilities. This paper explores the convergence of LLM reasoning techniques and feature generation for machine learning…

Computation and Language · Computer Science 2025-03-21 Dharani Chandra

Inspired by the success of large language models (LLM) for DNA and proteins, several LLM for RNA have been developed recently. RNA-LLM uses large datasets of RNA sequences to learn, in a self-supervised way, how to represent each RNA base…

Artificial Intelligence · Computer Science 2025-02-04 L. I. Zablocki , L. A. Bugnon , M. Gerard , L. Di Persia , G. Stegmayer , D. H. Milone

Estimating sewing patterns from images is a practical approach for creating high-quality 3D garments, but it remains challenging due to the scarcity of paired real-world image and sewing-pattern data. Existing methods address this…

Computer Vision and Pattern Recognition · Computer Science 2026-05-20 Anna Badalyan , Pratheba Selvaraju , Giorgio Becherini , Omid Taheri , Victoria Fernandez Abrevaya , Michael Black

The analysis of DNA sequences has become critical in numerous fields, from evolutionary biology to understanding gene regulation and disease mechanisms. While deep neural networks can achieve remarkable predictive performance, they…

Machine Learning · Computer Science 2026-04-15 Nicolas Huynh , Krzysztof Kacprzyk , Ryan Sheridan , David Bentley , Mihaela van der Schaar

Pretraining DNA language models (DNALMs) on the full human genome is resource-intensive, yet often considered necessary for strong downstream performance. Inspired by recent findings in NLP and long-context modeling, we explore an…

Genomics · Quantitative Biology 2025-06-24 Sohan Mupparapu , Parameswari Krishnamurthy , Ratish Puduppully

Large language models (LLMs) show promise in code translation due to their ability to generate idiomatic code. However, a significant limitation when using LLMs for code translation is scalability: existing works have shown a drop in…

Programming Languages · Computer Science 2024-12-12 Hanliang Zhang , Cristina David , Meng Wang , Brandon Paulsen , Daniel Kroening

Genome data are crucial in modern medicine, offering significant potential for diagnosis and treatment. Thanks to technological advancements, many millions of healthy and diseased genomes have already been sequenced; however, obtaining the…

Genomics · Quantitative Biology 2024-06-18 Teddy Lazebnik , Liron Simon-Keren

The genome sequence contains the blueprint for governing cellular processes. While the availability of genomes has vastly increased over the last decades, experimental annotation of the various functional, non-coding and regulatory elements…

Genomics · Quantitative Biology 2024-04-10 Frederikke Isa Marin , Felix Teufel , Marc Horlacher , Dennis Madsen , Dennis Pultz , Ole Winther , Wouter Boomsma

Frame-semantic parsing is a critical task in natural language understanding, yet the ability of large language models (LLMs) to extract frame-semantic arguments remains underexplored. This paper presents a comprehensive evaluation of LLMs…

Computation and Language · Computer Science 2025-02-19 Jacob Devasier , Rishabh Mediratta , Chengkai Li

Large Language Models (LLMs) are increasingly integrated into the software engineering ecosystem. Their test-time compute (TTC) reasoning capabilities show significant potential for understanding program logic and semantics beyond mere…

Computation and Language · Computer Science 2025-10-22 Yifeng He , Luning Yang , Christopher Castro Gaw Gonzalo , Hao Chen

Proteins are essential macromolecules defined by their amino acid sequences, which determine their three-dimensional structures and, consequently, their functions in all living organisms. Therefore, generative protein modeling necessitates…

Machine Learning · Computer Science 2024-10-18 Xinyou Wang , Zaixiang Zheng , Fei Ye , Dongyu Xue , Shujian Huang , Quanquan Gu

Deep Generative Models (DGMs) are versatile tools for learning data representations while adequately incorporating domain knowledge such as the specification of conditional probability distributions. Recently proposed DGMs tackle the…

Machine Learning · Computer Science 2024-01-30 Romain Lopez , Jan-Christian Huetter , Ehsan Hajiramezanali , Jonathan Pritchard , Aviv Regev

In recent years, transformer-based large language models (LLMs) have revolutionised natural language processing (NLP), with generative models opening new possibilities for tasks that require context-aware text generation. Requirements…

Computation and Language · Computer Science 2025-04-24 Waad Alhoshan , Alessio Ferrari , Liping Zhao

While Language Models (LMs) are the workhorses of NLP, their interplay with structured knowledge graphs (KGs) is still actively researched. Current methods for encoding such graphs typically either (i) linearize them for embedding with LMs…

Computation and Language · Computer Science 2024-06-04 Moritz Plenz , Anette Frank

Vision-language models (VLMs) are impactful in part because they can be applied to a variety of visual understanding tasks in a zero-shot fashion, without any fine-tuning. We study $\textit{generative VLMs}$ that are trained for next-word…

Computer Vision and Pattern Recognition · Computer Science 2024-05-16 Zhiqiu Lin , Xinyue Chen , Deepak Pathak , Pengchuan Zhang , Deva Ramanan

In machine learning, Neural Architecture Search (NAS) requires domain knowledge of model design and a large amount of trial-and-error to achieve promising performance. Meanwhile, evolutionary algorithms have traditionally relied on fixed…

Neural and Evolutionary Computing · Computer Science 2025-04-04 YiMing Yu , Jason Zutty

Variant and gene interpretation are fundamental to personalized medicine and translational biomedicine. However, traditional approaches are manual and labor-intensive. Generative language models (LMs) can facilitate this process,…

Artificial Intelligence · Computer Science 2025-10-15 Owen Queen , Harrison G. Zhang , James Zou

Recently, deep neural networks (DNNs) have achieved great success in semantically challenging NLP tasks, yet it remains unclear whether DNN models can capture compositional meanings, those aspects of meaning that have been long studied in…

Computation and Language · Computer Science 2021-06-03 Hitomi Yanaka , Koji Mineshima , Kentaro Inui

Recent advances in genomic sequencing technology have resulted in an abundance of genome sequence data. Despite the progress in interpreting those data, there remains a broad scope for their translation into clinical and societal benefits.…

Genomics · Quantitative Biology 2021-12-13 Abhinav Jain , Greg Slabaugh , Deepti Gurdasani