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The Genomic Foundation Model (GFM) paradigm is expected to facilitate the extraction of generalizable representations from massive genomic data, thereby enabling their application across a spectrum of downstream applications. Despite…

Genomics · Quantitative Biology 2024-06-06 Zicheng Liu , Jiahui Li , Siyuan Li , Zelin Zang , Cheng Tan , Yufei Huang , Yajing Bai , Stan Z. Li

Deciphering the function of unseen protein sequences is a fundamental challenge with broad scientific impact, yet most existing methods depend on task-specific adapters or large-scale supervised fine-tuning. We introduce the…

Machine Learning · Computer Science 2025-10-14 Xinhui Chen , Zuchao Li , Mengqi Gao , Yufeng Zhang , Chak Tou Leong , Haoyang Li , Jiaqi Chen

Large language models (LLMs) offer new opportunities for automated data extraction and property prediction across materials science, yet their use in superconductivity research remains limited. Here we construct a large experimental…

Materials Science · Physics 2025-12-12 Suman Itani , Yibo Zhang , Ranjit Itani , Jiadong Zang

Language models (LMs) are said to be exhibiting reasoning, but what does this entail? We assess definitions of reasoning and how key papers in the field of natural language processing (NLP) use the notion and argue that the definitions…

Computation and Language · Computer Science 2025-11-18 Bertram Højer

Recent studies have adopted pre-trained language models, such as CodeT5 and CodeGPT, for automated program generation tasks like code generation, repair, and translation. Numerous language model-based approaches have been proposed and…

Software Engineering · Computer Science 2024-01-09 Yue Liu , Chakkrit Tantithamthavorn , Yonghui Liu , Li Li

Large language models are now used daily for writing, search, and analysis, and their natural language understanding continues to improve. However, they remain unreliable on exact numerical calculation and on producing outputs that are…

Computation and Language · Computer Science 2026-02-10 Hendrika Maclean , Mert Can Cakmak , Muzakkiruddin Ahmed Mohammed , Shames Al Mandalawi , John Talburt

Despite their ability to understand chemical knowledge, large language models (LLMs) remain limited in their capacity to propose novel molecules with desired functions (e.g., drug-like properties). In addition, the molecules that LLMs…

The integration of multi-omic data is pivotal for understanding complex diseases, but its high dimensionality and noise present significant challenges. Graph Neural Networks (GNNs) offer a robust framework for analyzing large-scale…

Quantitative Methods · Quantitative Biology 2024-12-23 Heming Zhang , Di Huang , Yixin Chen , Fuhai Li

Automated interlinear gloss prediction with neural networks is a promising approach to accelerate language documentation efforts. However, while state-of-the-art models like GlossLM achieve high scores on glossing benchmarks, user studies…

Computation and Language · Computer Science 2026-01-26 Michael Ginn , Lindia Tjuatja , Enora Rice , Ali Marashian , Maria Valentini , Jasmine Xu , Graham Neubig , Alexis Palmer

In the field of chemistry, the objective is to create novel molecules with desired properties, facilitating accurate property predictions for applications such as material design and drug screening. However, existing graph deep learning…

Machine Learning · Computer Science 2024-08-28 Sakhinana Sagar Srinivas , Venkataramana Runkana

Negation has been shown to be a major bottleneck for masked language models, such as BERT. However, whether this finding still holds for larger-sized auto-regressive language models (``LLMs'') has not been studied comprehensively. With the…

Computation and Language · Computer Science 2023-06-16 Thinh Hung Truong , Timothy Baldwin , Karin Verspoor , Trevor Cohn

Large Language Models (LLMs) have successfully been applied to code generation tasks, raising the question of how well these models understand programming. Typical programming languages have invariances and equivariances in their semantics…

Computation and Language · Computer Science 2023-05-26 Antonio Valerio Miceli-Barone , Fazl Barez , Ioannis Konstas , Shay B. Cohen

Crafting effective features is a crucial yet labor-intensive and domain-specific task within machine learning pipelines. Fortunately, recent advancements in Large Language Models (LLMs) have shown promise in automating various data science…

Computation and Language · Computer Science 2024-10-18 Yanlin Zhang , Ning Li , Quan Gan , Weinan Zhang , David Wipf , Minjie Wang

The advent of large language models (LLMs) has enabled significant performance gains in the field of natural language processing. However, recent studies have found that LLMs often resort to shortcuts when performing tasks, creating an…

Computation and Language · Computer Science 2024-12-18 Geetanjali Bihani , Julia Taylor Rayz

Large Language Models (LLMs) stand at the forefront of a number of Natural Language Processing (NLP) tasks. Despite the widespread adoption of LLMs in NLP, much of their potential in broader fields remains largely unexplored, and…

Machine Learning · Computer Science 2024-03-11 Zhiqiang Zhong , Kuangyu Zhou , Davide Mottin

Large language models (LLMs) demonstrate great potential for problems with implicit graphical structures, while recent works seek to enhance the graph reasoning capabilities of LLMs through specialized instruction tuning. The resulting…

Computation and Language · Computer Science 2024-10-14 Yizhuo Zhang , Heng Wang , Shangbin Feng , Zhaoxuan Tan , Xiaochuang Han , Tianxing He , Yulia Tsvetkov

State-of-the-art natural language processing (NLP) models are trained on massive training corpora, and report a superlative performance on evaluation datasets. This survey delves into an important attribute of these datasets: the dialect of…

Computation and Language · Computer Science 2024-12-10 Aditya Joshi , Raj Dabre , Diptesh Kanojia , Zhuang Li , Haolan Zhan , Gholamreza Haffari , Doris Dippold

In this paper we present the first investigation into the effectiveness of Large Language Models (LLMs) for Failure Mode Classification (FMC). FMC, the task of automatically labelling an observation with a corresponding failure mode code,…

Computation and Language · Computer Science 2023-09-18 Michael Stewart , Melinda Hodkiewicz , Sirui Li

Large Language Models (LLMs) are increasingly integrated into software engineering workflows, yet current benchmarks provide only coarse performance summaries that obscure the diverse capabilities and limitations of these models. This paper…

Software Engineering · Computer Science 2026-01-21 Felix Mächtle , Jan-Niclas Serr , Nils Loose , Thomas Eisenbarth

Neural network language models (NNLMs) have achieved ever-improving accuracy due to more sophisticated architectures and increasing amounts of training data. However, the inductive bias of these models (formed by the distributional…

Machine Learning · Computer Science 2019-12-12 David Demeter , Doug Downey