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High-dose-rate (HDR) brachytherapy plays a critical role in the treatment of locally advanced cervical cancer but remains highly dependent on manual treatment planning expertise. The objective of this study is to develop a fully automated…

Clinically significant prostate cancer has a better chance to be sampled during ultrasound-guided biopsy procedures, if suspected lesions found in pre-operative magnetic resonance (MR) images are used as targets. However, the diagnostic…

Machine Learning · Computer Science 2022-07-25 Iani JMB Gayo , Shaheer U. Saeed , Dean C. Barratt , Matthew J. Clarkson , Yipeng Hu

Anatomical changes during intensity-modulated proton therapy (IMPT) for head-and-neck cancer (HNC) can shift Bragg peaks, risking tumor underdosing and organ-at-risk overdosing. Treatment replanning is often required to maintain clinically…

Medical Physics · Physics 2025-08-13 Malvern Madondo , Yuan Shao , Yingzi Liu , Jun Zhou , Xiaofeng Yang , Zhen Tian

Proton pencil beam scanning (PBS) treatment planning for head and neck (H&N) cancers is a time-consuming and experience-demanding task where a large number of planning objectives are involved. Deep reinforcement learning (DRL) has recently…

Quantitative Methods · Quantitative Biology 2024-09-19 Qingqing Wang , Chang Chang

Regrasping a suture needle is an important yet time-consuming process in suturing. To bring efficiency into regrasping, prior work either designs a task-specific mechanism or guides the gripper toward some specific pick-up point for proper…

Robotics · Computer Science 2021-05-25 Zih-Yun Chiu , Florian Richter , Emily K. Funk , Ryan K. Orosco , Michael C. Yip

Background: Real-time treatment planning in IMRT is challenging due to complex beam interactions. AI has improved automation, but existing models require large, high-quality datasets and lack universal applicability. Deep reinforcement…

Medical Physics · Physics 2025-02-26 Md Mainul Abrar , Parvat Sapkota , Damon Sprouts , Xun Jia , Yujie Chi

Cryoablation is a minimally invasive localised treatment for prostate cancer that destroys malignant tissue during de-freezing, while sparing surrounding healthy structures. Its success depends on accurate preoperative planning of cryoprobe…

Computer Vision and Pattern Recognition · Computer Science 2025-10-22 Trixia Simangan , Ahmed Nadeem Abbasi , Yipeng Hu , Shaheer U. Saeed

High-dose-rate brachytherapy is a tumor treatment method where a highly radioactive source is brought in close proximity to the tumor. In this paper we develop a simulated annealing algorithm to optimize the dwell times at preselected dwell…

Medical Physics · Physics 2017-03-29 Timo M. Deist , Bram L. Gorissen

Purpose: Automatic planning for focal low-dose-rate prostate brachytherapy (LDR-PB) boost. Methods: A simulated annealing approach was utilized for creating automatic focal LDR-PB boost plans using both geometric (i.e. adherence of isodose…

Medical Physics · Physics 2020-10-27 S. Sara Mahdavi , Michael D. Peacock , William J. Morris , Ingrid T. Spadinger

This paper presents the first deep reinforcement learning (DRL) framework to estimate the optimal Dynamic Treatment Regimes from observational medical data. This framework is more flexible and adaptive for high dimensional action and state…

Artificial Intelligence · Computer Science 2018-01-30 Ning Liu , Ying Liu , Brent Logan , Zhiyuan Xu , Jian Tang , Yanzhi Wang

Reinforcement Learning (RL) can be used to fit a mapping from patient state to a medication regimen. Prior studies have used deterministic and value-based tabular learning to learn a propofol dose from an observed anesthetic state. Deep RL…

Machine Learning · Computer Science 2020-09-10 Gabe Schamberg , Marcus Badgeley , Emery N. Brown

The goal of precision medicine is to provide individualized treatment at each stage of chronic diseases, a concept formalized by Dynamic Treatment Regimes (DTR). These regimes adapt treatment strategies based on decision rules learned from…

Methodology · Statistics 2025-06-09 Sophia Yazzourh , Nicolas Savy , Philippe Saint-Pierre , Michael R. Kosorok

Inverse treatment planning in radiation therapy is formulated as optimization problems. The objective function and constraints consist of multiple terms designed for different clinical and practical considerations. Weighting factors of…

Radiotherapy (RT) is a critical cancer treatment, with volumetric modulated arc therapy (VMAT) being a commonly used technique that enhances dose conformity by dynamically adjusting multileaf collimator (MLC) positions and monitor units…

Medical Physics · Physics 2025-06-26 Stefanos Achlatis , Efstratios Gavves , Jan-Jakob Sonke

Purpose: To develop a virtual reality simulator for high dose rate prostate brachytherapy and to test whether participation is associated with immediate gains in self-reported confidence across predefined procedural domains in two cohorts.…

To develop an automated workflow for rectal cancer three-dimensional conformal radiotherapy treatment planning that combines deep-learning(DL) aperture predictions and forward-planning algorithms. We designed an algorithm to automate the…

Reinforcement learning (RL) involves sequential decision making in uncertain environments. The aim of the decision-making agent is to maximize the benefit of acting in its environment over an extended period of time. Finding an optimal…

Artificial Intelligence · Computer Science 2007-05-23 Istvan Szita , Balint Takacs , Andras Lorincz

We introduce a novel implementation of a reinforcement learning (RL) algorithm which is designed to find an optimal jet grooming strategy, a critical tool for collider experiments. The RL agent is trained with a reward function constructed…

High Energy Physics - Phenomenology · Physics 2019-07-24 Stefano Carrazza , Frédéric A. Dreyer

Deep learning-based automated contouring and treatment planning has been proven to improve the efficiency and accuracy of radiotherapy. However, conventional radiotherapy treatment planning process has the automated contouring and treatment…

Medical Physics · Physics 2024-12-02 Sangwook Kim , Aly Khalifa , Thomas G. Purdie , Chris McIntosh

A big challenge in branch and bound lies in identifying the optimal node within the search tree from which to proceed. Current state-of-the-art selectors utilize either hand-crafted ensembles that automatically switch between naive sub-node…

Machine Learning · Computer Science 2024-06-06 Alexander Mattick , Christopher Mutschler
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