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Purpose: The integration of multimodal imaging into operating rooms paves the way for comprehensive surgical scene understanding. In ophthalmic surgery, by now, two complementary imaging modalities are available: operating microscope (OPMI)…

Computer Vision and Pattern Recognition · Computer Science 2026-03-27 Nikolo Rohrmoser , Ghazal Ghazaei , Michael Sommersperger , Nassir Navab

While large language models (LLMs) have achieved state-of-the-art performance on a wide range of medical question answering (QA) tasks, they still face challenges with hallucinations and outdated knowledge. Retrieval-augmented generation…

Computation and Language · Computer Science 2024-02-26 Guangzhi Xiong , Qiao Jin , Zhiyong Lu , Aidong Zhang

Optical coherence tomography (OCT) is a non-invasive 3D modality widely used in ophthalmology for imaging the retina. Achieving automated, anatomically coherent retinal layer segmentation on OCT is important for the detection and monitoring…

Image and Video Processing · Electrical Eng. & Systems 2022-10-26 Botond Fazekas , Guilherme Aresta , Dmitrii Lachinov , Sophie Riedl , Julia Mai , Ursula Schmidt-Erfurth , Hrvoje Bogunovic

Artificial intelligence has shown promise in medical imaging, yet most existing systems lack flexibility, interpretability, and adaptability - challenges especially pronounced in ophthalmology, where diverse imaging modalities are…

To effectively leverage user-specific data, retrieval augmented generation (RAG) is employed in multimodal large language model (MLLM) applications. However, conventional retrieval approaches often suffer from limited retrieval accuracy.…

Computer Vision and Pattern Recognition · Computer Science 2026-03-04 Maoliang Li , Ke Li , Yaoyang Liu , Jiayu Chen , Zihao Zheng , Yinjun Wu , Chenchen Liu , Xiang Chen

Vision-threatening eye diseases pose a major global health burden, with timely diagnosis limited by workforce shortages and restricted access to specialized care. While multimodal large language models (MLLMs) show promise for medical image…

In this paper, we propose a novel retinal layer boundary model for segmentation of optical coherence tomography (OCT) images. The retinal layer boundary model consists of 9 open parametric contours representing the 9 retinal layers in OCT…

Computer Vision and Pattern Recognition · Computer Science 2018-08-10 Jinming Duan , Weicheng Xie , Ryan Wen Liu , Christopher Tench , Irene Gottlob , Frank Proudlock , Li Bai

Intrinsic optical signal (IOS) imaging of the retina, also termed as optoretinography (ORG), promises a noninvasive method for objective assessment of retinal function. By providing unparalleled capability to differentiate individual layers…

Medical Physics · Physics 2022-02-22 Tae-Hoon Kim , Guangying Ma , Taeyoon Son , Xincheng Yao

The rise of imaging techniques such as optical coherence tomography (OCT) and advances in deep learning (DL) have enabled clinicians and researchers to streamline retinal disease staging. A popular DL approach is self-supervised learning…

Computer Vision and Pattern Recognition · Computer Science 2025-06-30 Ronald Fecso , José Morano , Ursula Schmidt-Erfurth , Hrvoje Bogunović

Optical Coherence Tomography (OCT) is one of the most emerging imaging modalities that has been used widely in the field of biomedical imaging. From its emergence in 1990's, plenty of hardware and software improvements have been made. Its…

Computer Vision and Pattern Recognition · Computer Science 2014-11-18 Ahmadreza Baghaie , Roshan M. D'souza , Zeyun Yu

Optical Coherence Tomography (OCT) has become one of the most used imaging modality in ophthalmology. It provides high-resolution, non-invasive visualization of retinal microarchitecture. The automated analysis of OCT images through…

Computer Vision and Pattern Recognition · Computer Science 2026-05-05 Hedi Tabia , Désiré Sidibé , Nawres Khlifa , Ahmed Tabia , Ines Rahmany , Noura Aboudi , Zainab Haddad , Hajer Khachnaoui , Hsouna Zgolli

We introduce MiRAGE, an evaluation framework for retrieval-augmented generation (RAG) from multimodal sources. As audiovisual media becomes a prevalent source of information online, it is essential for RAG systems to integrate information…

Computation and Language · Computer Science 2025-10-30 Alexander Martin , William Walden , Reno Kriz , Dengjia Zhang , Kate Sanders , Eugene Yang , Chihsheng Jin , Benjamin Van Durme

Optical coherence tomography (OCT) has stimulated a wide range of medical image-based diagnosis and treatment in fields such as cardiology and ophthalmology. Such applications can be further facilitated by deep learning-based…

Medical Physics · Physics 2023-07-24 Xueshen Li , Zhenxing Dong , Hongshan Liu , Jennifer J. Kang-Mieler , Yuye Ling , Yu Gan

Optical coherence tomography (OCT) is a prevalent imaging technique for retina. However, it is affected by multiplicative speckle noise that can degrade the visibility of essential anatomical structures, including blood vessels and tissue…

Image and Video Processing · Electrical Eng. & Systems 2021-07-12 Dewei Hu , Joseph D. Malone , Yigit Atay , Yuankai K. Tao , Ipek Oguz

Optical coherence tomography (OCT), a commonly used retinal imaging modality, plays a central role in retinal disease diagnosis by providing high-resolution visualization of retinal layers. While deep learning (DL) has achieved expert-level…

Computer Vision and Pattern Recognition · Computer Science 2026-05-05 Tienyu Chang , Tianhao Li , Ruogu Fang , Jiang Bian , Yu Huang

Ensuring equitable Artificial Intelligence (AI) in healthcare demands systems that make unbiased decisions across all demographic groups, bridging technical innovation with ethical principles. Foundation Models (FMs), trained on vast…

Computer Vision and Pattern Recognition · Computer Science 2026-01-15 Dilermando Queiroz , Anderson Carlos , André Anjos , Lilian Berton

Recent learning-based approaches have made astonishing advances in calibrated medical imaging like computerized tomography (CT), yet they struggle to generalize in uncalibrated modalities -- notably magnetic resonance (MR) imaging, where…

Computer Vision and Pattern Recognition · Computer Science 2025-09-03 Peirong Liu , Oula Puonti , Xiaoling Hu , Karthik Gopinath , Annabel Sorby-Adams , Daniel C. Alexander , W. Taylor Kimberly , Juan E. Iglesias

High-resolution Optical Coherence Tomography (OCT) images are crucial for ophthalmology studies but are limited by their relatively narrow field of view (FoV). Image mosaicking is a technique for aligning multiple overlapping images to…

Image and Video Processing · Electrical Eng. & Systems 2024-07-29 Jiacheng Wang , Hao Li , Dewei Hu , Yuankai K. Tao , Ipek Oguz

Optical coherence tomography (OCT) is a commonly-used method of extracting high resolution retinal information. Moreover there is an increasing demand for the automated retinal layer segmentation which facilitates the retinal disease…

Image and Video Processing · Electrical Eng. & Systems 2020-09-30 Zeyu Fu , Yang Sun , Xiangyu Zhang , Scott Stainton , Shaun Barney , Jeffry Hogg , William Innes , Satnam Dlay

Optical tomographic cross-sectional images of biological samples were made possible by interferometric imaging techniques such as Optical Coherence Tomography (OCT). Owing to its unprecedented view of the sample, OCT has become a gold…

Medical Physics · Physics 2020-07-13 Pedro Mecê , Elena Gofas-Salas , Michel Paques , Kate Grieve , Serge Meimon