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Density ratio estimation is fundamental to tasks involving $f$-divergences, yet existing methods often fail under significantly different distributions or inadequately overlapping supports -- the density-chasm and the support-chasm…

Machine Learning · Computer Science 2025-11-04 Wei Chen , Shigui Li , Jiacheng Li , Junmei Yang , John Paisley , Delu Zeng

Diffusion models are central to generative modeling and have been adapted to graphs by diffusing adjacency matrix representations. The challenge of having up to $n!$ such representations for graphs with $n$ nodes is only partially mitigated…

By framing reinforcement learning as a sequence modeling problem, recent work has enabled the use of generative models, such as diffusion models, for planning. While these models are effective in predicting long-horizon state trajectories…

The task of deducing three-dimensional molecular configurations from their two-dimensional graph representations holds paramount importance in the fields of computational chemistry and pharmaceutical development. The rapid advancement of…

Biomolecules · Quantitative Biology 2025-01-09 Bobin Yang , Jie Deng , Zhenghan Chen , Ruoxue Wu

In this study, we introduce a novel method for generating new synthetic samples that are independent and identically distributed (i.i.d.) from high-dimensional real-valued probability distributions, as defined implicitly by a set of Ground…

Machine Learning · Statistics 2024-07-09 Hamidreza Behjoo , Michael Chertkov

Generative modeling becomes increasingly data-intensive in high-dimensional spaces. In molecular science, where data collection is expensive and important events are rare, compression to lower-dimensional manifolds is especially important…

Machine Learning · Computer Science 2025-10-14 Richard John , Yunrui Qiu , Lukas Herron , Pratyush Tiwary

Text-to-image diffusion models have recently attracted the interest of many researchers, and inverting the diffusion process can play an important role in better understanding the generative process and how to engineer prompts in order to…

Computer Vision and Pattern Recognition · Computer Science 2024-10-22 Florinel-Alin Croitoru , Vlad Hondru , Radu Tudor Ionescu , Mubarak Shah

Image-to-image translation is an important and challenging problem in computer vision and image processing. Diffusion models (DM) have shown great potentials for high-quality image synthesis, and have gained competitive performance on the…

Computer Vision and Pattern Recognition · Computer Science 2023-03-24 Bo Li , Kaitao Xue , Bin Liu , Yu-Kun Lai

Denoising diffusion probabilistic models (DDPMs) (Ho et al. 2020) have shown impressive results on image and waveform generation in continuous state spaces. Here, we introduce Discrete Denoising Diffusion Probabilistic Models (D3PMs),…

Machine Learning · Computer Science 2023-02-23 Jacob Austin , Daniel D. Johnson , Jonathan Ho , Daniel Tarlow , Rianne van den Berg

Switching dynamical systems provide a powerful, interpretable modeling framework for inference in time-series data in, e.g., the natural sciences or engineering applications. Since many areas, such as biology or discrete-event systems, are…

Machine Learning · Computer Science 2021-09-30 Lukas Köhs , Bastian Alt , Heinz Koeppl

Deep Gaussian processes (DGPs) enable expressive hierarchical Bayesian modeling but pose substantial challenges for posterior inference, especially over inducing variables. Denoising diffusion variational inference (DDVI) addresses this by…

Machine Learning · Computer Science 2026-02-13 Jian Xu , Qibin Zhao , John Paisley , Delu Zeng

In stochastic systems, numerically sampling the relevant trajectories for the estimation of the large deviation statistics of time-extensive observables requires overcoming their exponential (in space and time) scarcity. The optimal way to…

Statistical Mechanics · Physics 2021-01-14 Tom H. E. Oakes , Adam Moss , Juan P. Garrahan

Adapting a pretrained diffusion model to new objectives at inference time remains an open problem in generative modeling. Existing steering methods suffer from inaccurate value estimation, especially at high noise levels, which biases…

Machine Learning · Computer Science 2025-06-27 Vineet Jain , Kusha Sareen , Mohammad Pedramfar , Siamak Ravanbakhsh

The exploration of transition state (TS) geometries is crucial for elucidating chemical reaction mechanisms and modeling their kinetics. Recently, machine learning (ML) models have shown remarkable performance for prediction of TS…

Chemical Physics · Physics 2023-10-13 Seonghwan Kim , Jeheon Woo , Woo Youn Kim

Diffusion models are the mainstream approach for time series generation tasks. However, existing diffusion models for time series generation require retraining the entire framework to introduce specific conditional guidance. There also…

Machine Learning · Computer Science 2025-09-25 Mingchun Sun , Rongqiang Zhao , Hengrui Hu , Songyu Ding , Jie Liu

We present Bayesian Diffusion Models (BDM), a prediction algorithm that performs effective Bayesian inference by tightly coupling the top-down (prior) information with the bottom-up (data-driven) procedure via joint diffusion processes. We…

Computer Vision and Pattern Recognition · Computer Science 2024-04-23 Haiyang Xu , Yu Lei , Zeyuan Chen , Xiang Zhang , Yue Zhao , Yilin Wang , Zhuowen Tu

Audio-visual deepfake localization demands interval-level outputs that serve as temporal evidence. Despite recent progress, symmetric fusion under single-sided or asynchronous forgeries propagates cross-modal noise, degrading high-precision…

Computer Vision and Pattern Recognition · Computer Science 2026-05-25 Jiayu Xiong , Jing Wang , Qi Zhang , Wanlong Wang , Jun Xue

The inadequate mixing of conventional Markov Chain Monte Carlo (MCMC) methods for multi-modal distributions presents a significant challenge in practical applications such as Bayesian inference and molecular dynamics. Addressing this, we…

Machine Learning · Statistics 2024-05-30 Wenlin Chen , Mingtian Zhang , Brooks Paige , José Miguel Hernández-Lobato , David Barber

We extend Regularised Diffusion-Shock (RDS) filtering from Euclidean space $\mathbb{R}_2$ [1] to position-orientation space $\mathbb{M}_2 \cong \mathbb{R}^2 \times S^1$. This has numerous advantages, e.g. making it possible to enhance and…

Differential Geometry · Mathematics 2026-03-20 Finn M. Sherry , Kristina Schaefer , Remco Duits

Diffusion models have shown promising generative capabilities across diverse domains, yet aligning their outputs with desired reward functions remains a challenge, particularly in cases where reward functions are non-differentiable. Some…

Machine Learning · Computer Science 2025-06-04 Xiner Li , Masatoshi Uehara , Xingyu Su , Gabriele Scalia , Tommaso Biancalani , Aviv Regev , Sergey Levine , Shuiwang Ji