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The Quadratic Unconstrained Binary Optimization problem (QUBO) has become a unifying model for representing a wide range of combinatorial optimization problems, and for linking a variety of disciplines that face these problems. A new class…

Artificial Intelligence · Computer Science 2017-05-30 Mark Lewis , Fred Glover

Realizing the potential of near-term quantum computers to solve industry-relevant constrained-optimization problems is a promising path to quantum advantage. In this work, we consider the extractive summarization constrained-optimization…

The RSA cryptosystem, which relies on the computational difficulty of prime factorization, faces growing challenges with the advancement of quantum computing. In this study, we propose a quantum annealing based approach to integer…

Quantum Physics · Physics 2025-06-23 Arim Ryou , Kiwoong Kim , Kyungtaek Jun

Quantum approaches to combinatorial optimization problems (COPs) are often limited by the resource demands of Quadratic Unconstrained Binary Optimization (QUBO) encodings, which enlarge circuits through penalty terms and increase qubit and…

Quantum Physics · Physics 2025-11-25 Frederik Koch , Shahram Panahiyan , Rick Mukherjee , Joseph Doetsch , Dieter Jaksch

In the pursuit of achieving near-term quantum advantage for combinatorial optimization problems, the Quantum Approximate Optimization Algorithm (QAOA) and the Variational Quantum Eigensolver (VQE) are the primary methods of interest, but…

Quantum Physics · Physics 2025-03-06 Adelina Bärligea , Benedikt Poggel , Jeanette Miriam Lorenz

NP-hard problems are not believed to be exactly solvable through general polynomial time algorithms. Hybrid quantum-classical algorithms to address such combinatorial problems have been of great interest in the past few years. Such…

Quantum Physics · Physics 2024-01-15 Yagnik Chatterjee , Eric Bourreau , Marko J. Rančić

We propose an approach to solving constrained combinatorial optimization problems based on embedding the concept of Lagrangian duality into the framework of adiabatic quantum computation. Within the setting of circuit-model fault-tolerant…

Optimization and Control · Mathematics 2024-04-30 Einar Gabbassov , Gili Rosenberg , Artur Scherer

Today, hardware constraints are an important limitation on quantum adiabatic optimization algorithms. Firstly, computational problems must be formulated as quadratic unconstrained binary optimization (QUBO) in the presence of noisy coupling…

Quantum Physics · Physics 2018-12-06 Andrew Lucas

Several combinatorial optimization problems can be solved with NISQ devices once that a corresponding quadratic unconstrained binary optimization (QUBO) form is derived. The aim of this work is to drastically reduce the variables needed for…

Quantum Physics · Physics 2026-02-25 Dario De Santis , Salvatore Tirone , Stefano Marmi , Vittorio Giovannetti

We study the performance scaling of three quantum algorithms for combinatorial optimization: measurement-feedback coherent Ising machines (MFB-CIM), discrete adiabatic quantum computation (DAQC), and the D\"urr-Hoyer algorithm for quantum…

Encoding combinatorial optimization problems into physically meaningful Hamiltonians with tractable energy landscapes forms the foundation of quantum optimization. Numerous works have studied such efficient encodings for the class of…

Quantum Physics · Physics 2026-02-12 Sebastian Egginger , Kristina Kirova , Sonja Bruckner , Stefan Hillmich , Richard Kueng

Predicting the 3D structure of proteins is one of the most important problems in current biochemical research. In this article, we explain how to combine recent deep learning advances with the well known technique of quantum walks applied…

Quantum Physics · Physics 2022-03-10 P A M Casares , Roberto Campos , M A Martin-Delgado

To implement useful quantum algorithms which demonstrate quantum advantage, we must scale currently demonstrated quantum computers up significantly. Leading platforms such as trapped ions face physical challenges in including more…

Quantum Physics · Physics 2023-06-07 Pei Jiang Low , Brendan White , Crystal Senko

Quantum computers can solve certain problems more efficiently than any possible conventional computer. Small quantum algorithms have been demonstrated on multiple quantum computing platforms, many specifically tailored in hardware to…

Quantum Physics · Physics 2016-08-05 S. Debnath , N. M. Linke , C. Figgatt , K. A. Landsman , K. Wright , C. Monroe

Combinatorial optimization problems are typically formulated using Quadratic Unconstrained Binary Optimization (QUBO), where constraints are enforced through penalty terms that introduce auxiliary variables and rapidly increase Hamiltonian…

Quantum Physics · Physics 2026-02-10 Shashank Sanjay Bhat , Peiyong Wang , Joseph West , Udaya Parampalli

Renewable energy optimisation poses computationally-intensive challenges. Yet, often the continuous nature of the decision space precludes the use of many emerging, non-von-Neumann computing platforms such as quantum annealing, which are…

Quantum Physics · Physics 2022-04-05 Mansour T. A. Sharabiani , Vibe B. Jakobsen , Martin Jeppesen , Alireza S. Mahani

Recent work at Fraunhofer FKIE shows that Morefield's method for multiple target data association can in theory be solved on an adiabatic quantum computer. The present paper validates the theory and examines the significant limitations of…

Quantum Physics · Physics 2021-10-19 Timothy M. McCormick , Bryan R. Osborn , R. Blair Angle , Roy L. Streit

Quantum algorithms have shown promise in solving Quadratic Unconstrained Binary Optimization (QUBO) problems, benefiting from their connection to the transverse field Ising model. Various Ising solvers, both classical and quantum, have…

Optimization and Control · Mathematics 2025-09-16 Zedong Peng , Daniel de Roux , David E. Bernal Neira

Molecular docking is a critical computational method in drug discovery used to predict the binding conformation and orientation of a ligand within a protein's binding site. Mapping this challenge onto a graph-based problem, specifically the…

Quantum Physics · Physics 2026-04-27 Mathieu Garrigues , Victor Onofre , Wesley Coelho , S. Acheche

Quantum annealing aims at solving optimization problems of practical relevance using quantum-computing hardware. Problems of interest are typically formulated in terms of quadratic unconstrained binary optimization (QUBO) Hamiltonians.…

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