Related papers: On Minimizers of Minimum Density
Minimizer schemes, or just minimizers, are a very important computational primitive in sampling and sketching biological strings. Assuming a fixed alphabet of size $\sigma$, a minimizer is defined by two integers $k,w\ge2$ and a total order…
Minimizers sampling is one of the most widely-used mechanisms for sampling strings [Roberts et al., Bioinformatics 2004]. Let $S=S[1]\ldots S[n]$ be a string over a totally ordered alphabet $\Sigma$. Further let $w\geq 2$ and $k\geq 1$ be…
Minimizers sampling is one of the most widely-used mechanisms for sampling strings. Let $S=S[0]\ldots S[n-1]$ be a string over an alphabet $\Sigma$. In addition, let $w\geq 2$ and $k\geq 1$ be two integers and $\rho=(\Sigma^k,\leq)$ be a…
In bioinformatics, minimizers have become an inescapable method for handling $k$-mers (words of fixed size $k$) extracted from DNA or RNA sequencing, whether for sampling, storage, querying or partitioning. According to some fixed order on…
The minimizers sampling mechanism is a popular mechanism for string sampling introduced independently by Schleimer et al. [SIGMOD 2003] and by Roberts et al. [Bioinf. 2004]. Given two positive integers $w$ and $k$, it selects the…
The minimizer of a word of size $k$ (a $k$-mer) is defined as its smallest substring of size $m$ (with $m\leq k$), according to some ordering on $m$-mers. minimizers have been used in bioinformatics -- notably -- to partition sequencing…
The extraction of $k$-mers is a fundamental component in many complex analyses of large next-generation sequencing datasets, including reads classification in genomics and the characterization of RNA-seq datasets. The extraction of all…
The sliding window model of computation captures scenarios in which data is arriving continuously, but only the latest $w$ elements should be used for analysis. The goal is to design algorithms that update the solution efficiently with each…
Metric $k$-center clustering is a fundamental unsupervised learning primitive. Although widely used, this primitive is heavily affected by noise in the data, so that a more sensible variant seeks for the best solution that disregards a…
A wide range of computer vision algorithms rely on identifying sparse interest points in images and establishing correspondences between them. However, only a subset of the initially identified interest points results in true…
String attractors [STOC 2018] are combinatorial objects recently introduced to unify all known dictionary compression techniques in a single theory. A set $\Gamma\subseteq [1..n]$ is a $k$-attractor for a string $S\in[1..\sigma]^n$ if and…
A string $w$ is called a minimal absent word (MAW) for a string $S$ if $w$ does not occur as a substring in $S$ and all proper substrings of $w$ occur in $S$. MAWs are well-studied combinatorial string objects that have potential…
Motivation: Building the histogram of occurrences of every $k$-symbol long substring of nucleotide data is a standard step in many bioinformatics applications, known under the name of $k$-mer counting. Its applications include developing de…
Background: Short sequence substrings of a fixed length k, called k-mers, are a ubiquitous computational primitive in bioinformatics, used across sequence indexing, read mapping, genome assembly, metagenomic classification, and comparative…
Biclustering is the task of simultaneously clustering the rows and columns of the data matrix into different subgroups such that the rows and columns within a subgroup exhibit similar patterns. In this paper, we consider the case of…
Given a set of strings over a specified alphabet, identifying a median or consensus string that minimizes the total distance to all input strings is a fundamental data aggregation problem. When the Hamming distance is considered as the…
In computational biology, $k$-mers and edit distance are fundamental concepts. However, little is known about the metric space of all $k$-mers equipped with the edit distance. In this work, we explore the structure of the $k$-mer space by…
Given a string $S$ over an alphabet $\Sigma$, the 'string indexing problem' is to preprocess $S$ to subsequently support efficient pattern matching queries, i.e., given a pattern string $P$ report all the occurrences of $P$ in $S$. In this…
A substring $u$ of a string $T$ is called a minimal unique substring (MUS) of $T$ if $u$ occurs exactly once in $T$ and any proper substring of $u$ occurs at least twice in $T$. A string $w$ is called a minimal absent word (MAW) of $T$ if…
The $k$-means method is an iterative clustering algorithm which associates each observation with one of $k$ clusters. It traditionally employs cluster centers in the same space as the observed data. By relaxing this requirement, it is…