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Flow Matching has emerged as a powerful framework for learning continuous transformations between distributions, enabling high-fidelity generative modeling. This work introduces Symmetrical Flow Matching (SymmFlow), a new formulation that…

Computer Vision and Pattern Recognition · Computer Science 2026-03-24 Francisco Caetano , Christiaan Viviers , Peter H. N. De With , Fons van der Sommen

Flow matching (FM) is a general framework for defining probability paths via Ordinary Differential Equations (ODEs) to transform between noise and data samples. Recent approaches attempt to straighten these flow trajectories to generate…

Computer Vision and Pattern Recognition · Computer Science 2024-07-03 Ling Yang , Zixiang Zhang , Zhilong Zhang , Xingchao Liu , Minkai Xu , Wentao Zhang , Chenlin Meng , Stefano Ermon , Bin Cui

Stereo matching is a core task for many computer vision and robotics applications. Despite their dominance in traditional stereo methods, the hand-crafted Markov Random Field (MRF) models lack sufficient modeling accuracy compared to…

Computer Vision and Pattern Recognition · Computer Science 2024-10-24 Tongfan Guan , Chen Wang , Yun-Hui Liu

Fine-tuning flow matching models is a central challenge in settings with limited data, evolving distributions, or strict efficiency demands, where unconstrained fine-tuning can erode the accuracy and efficiency gains learned during…

Machine Learning · Computer Science 2026-02-02 Gudrun Thorkelsdottir , Arindam Banerjee

We introduce Discrete flow Matching policy Optimization (DoMinO), a unified framework for Reinforcement Learning (RL) fine-tuning Discrete Flow Matching (DFM) models under a broad class of policy gradient methods. Our key idea is to view…

Machine Learning · Computer Science 2026-04-09 Maojiang Su , Po-Chung Hsieh , Weimin Wu , Mingcheng Lu , Jiunhau Chen , Jerry Yao-Chieh Hu , Han Liu

Chemical synthesis remains a critical bottleneck in the discovery and manufacture of functional small molecules. AI-based synthesis planning models could be a potential remedy to find effective syntheses, and have made progress in recent…

Reliably predicting the products of chemical reactions presents a fundamental challenge in synthetic chemistry. Existing machine learning approaches typically produce a reaction product by sequentially forming its subparts or intermediate…

Chemical Physics · Physics 2021-06-16 Hangrui Bi , Hengyi Wang , Chence Shi , Connor Coley , Jian Tang , Hongyu Guo

Trajectory prediction is critical for autonomous driving, enabling safe and efficient planning in dense, dynamic traffic. Most existing methods optimize prediction accuracy under fixed-length observations. However, real-world driving often…

Robotics · Computer Science 2026-03-12 Hao Zhou , Lu Qi , Jason Li , Jie Zhang , Yi Liu , Xu Yang , Mingyu Fan , Fei Luo

We consider the problem of designing constraint-aware flow matching (FM) models that address the issue of constraint violations commonly observed in vanilla generative models. We consider two scenarios, viz.: (a) when a differentiable…

Machine Learning · Computer Science 2026-05-01 Zhengyan Huan , Jacob Boerma , Li-Ping Liu , Shuchin Aeron

Retrosynthesis prediction focuses on identifying reactants capable of synthesizing a target product. Typically, the retrosynthesis prediction involves two phases: Reaction Center Identification and Reactant Generation. However, we argue…

Artificial Intelligence · Computer Science 2025-01-15 Shengyin Sun , Wenhao Yu , Yuxiang Ren , Weitao Du , Liwei Liu , Xuecang Zhang , Ying Hu , Chen Ma

A well-known pitfall of molecular generative models is that they are not guaranteed to generate synthesizable molecules. Existing solutions for this problem often struggle to effectively navigate exponentially large combinatorial space of…

Machine Learning · Computer Science 2026-01-13 Seul Lee , Karsten Kreis , Srimukh Prasad Veccham , Meng Liu , Danny Reidenbach , Saee Paliwal , Weili Nie , Arash Vahdat

Recently, the rectified flow (RF) has emerged as the new state-of-the-art among flow-based diffusion models due to its high efficiency advantage in straight path sampling, especially with the amazing images generated by a series of RF…

Computer Vision and Pattern Recognition · Computer Science 2025-06-11 Zhiyuan Ma , Ruixun Liu , Sixian Liu , Jianjun Li , Bowen Zhou

Recent progress in large-scale flow and diffusion models raised two fundamental algorithmic challenges: (i) control-based reward adaptation of pre-trained flows, and (ii) integration of multiple models, i.e., flow merging. While current…

Machine Learning · Computer Science 2026-02-10 Riccardo De Santi , Malte Franke , Ya-Ping Hsieh , Andreas Krause

The main target of retrosynthesis is to recursively decompose desired molecules into available building blocks. Existing template-based retrosynthesis methods follow a template selection stereotype and suffer from limited training…

Chemical Physics · Physics 2022-12-26 Chaochao Yan , Peilin Zhao , Chan Lu , Yang Yu , Junzhou Huang

Due to the increasing complexity of Integrated Circuits (ICs) and System-on-Chip (SoC), developing high-quality synthesis flows within a short market time becomes more challenging. We propose a general approach that precisely estimates the…

Machine Learning · Computer Science 2018-11-16 Cunxi Yu , Wang Zhou

Recent advances in inverse problem solving have increasingly adopted flow priors over diffusion models due to their ability to construct straight probability paths from noise to data, thereby enhancing efficiency in both training and…

Computer Vision and Pattern Recognition · Computer Science 2025-11-11 Hossein Askari , Yadan Luo , Hongfu Sun , Fred Roosta

Diffusion policies have achieved great success in online reinforcement learning (RL) due to their strong expressive capacity. However, the inference of diffusion policy models relies on a slow iterative sampling process, which limits their…

Machine Learning · Computer Science 2025-10-17 Tianyi Chen , Haitong Ma , Na Li , Kai Wang , Bo Dai

Currently, Flow matching methods aim to compress the iterative generation process of diffusion models into a few or even a single step, with MeanFlow and FreeFlow being representative achievements of one-step generation based on Ordinary…

Computer Vision and Pattern Recognition · Computer Science 2026-01-21 Haonan Wei , Linyuan Wang , Nuolin Sun , Zhizhong Zheng , Lei Li , Bin Yan

We introduce RapFlow-TTS, a rapid and high-fidelity TTS acoustic model that leverages velocity consistency constraints in flow matching (FM) training. Although ordinary differential equation (ODE)-based TTS generation achieves…

Audio and Speech Processing · Electrical Eng. & Systems 2025-06-23 Hyun Joon Park , Jeongmin Liu , Jin Sob Kim , Jeong Yeol Yang , Sung Won Han , Eunwoo Song

Single-cell genomics has significantly advanced our understanding of cellular behavior, catalyzing innovations in treatments and precision medicine. However, single-cell sequencing technologies are inherently destructive and can only…

Machine Learning · Statistics 2024-11-08 Dominik Klein , Théo Uscidda , Fabian Theis , Marco Cuturi