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Opioid misuse is a national epidemic and a significant drug related threat to the United States. While the scale of the problem is undeniable, estimates of the local prevalence of opioid misuse are lacking, despite their importance to…

Methodology · Statistics 2023-05-12 Staci A. Hepler , David Kline , Andrea Bonny , Erin McKnight , Lance A. Waller

Drug overdose deaths, including from opioids, remain a significant public health threat to the United States (US). To abate the harms of opioid misuse, understanding its prevalence at the local level is crucial for stakeholders in…

Applications · Statistics 2026-01-09 Zixuan Feng , Qiushi Chen , Paul Griffin , Le Bao

Monitoring small-area geographical population trends in opioid mortality has large scale implications to informing preventative resource allocation. A common approach to obtain small area estimates of opioid mortality is to use a standard…

Background: Opioid misuse is a major public health issue in the United States and in particular Ohio. However, the burden of the epidemic is challenging to quantify as public health surveillance measures capture different aspects of the…

Applications · Statistics 2018-06-15 Staci Hepler , Erin McKnight , Andrea Bonny , David Kline

The opioid epidemic is a crisis that has plagued the United States (US) for decades. One central issue is inequitable access to treatment for opioid use disorder (OUD), which puts certain populations at a higher risk of opioid overdose. We…

Physics and Society · Physics 2024-03-14 Joyce Luo , Bartolomeo Stellato

Opioid overdose is a growing public health crisis in the United States. This crisis, recognized as "opioid epidemic," has widespread societal consequences including the degradation of health, and the increase in crime rates and family…

Machine Learning · Computer Science 2020-06-01 Ali Mert Ertugrul , Yu-Ru Lin , Tugba Taskaya-Temizel

In recent years, techniques from Topological Data Analysis (TDA) have proven effective at capturing spatial features of multidimensional data. However, applying TDA to spatiotemporal data remains relatively underexplored. In this work, we…

Applications · Statistics 2025-09-30 Nicholas Bermingham , David White , Nathan Willey

The opioid epidemic remains a major public health challenge in the United States, requiring a multi-pronged intervention approach to mitigate harms to communities. Given the heterogeneity of the epidemic across the country, it is crucial…

Applications · Statistics 2026-04-13 Abdulrahman A. Ahmed , M. Amin Rahimian , Qiushi Chen , Praveen Kumar

We present efforts in the fields of machine learning and time series forecasting to accurately predict counts of future suspected opioid overdoses recorded by Emergency Medical Services (EMS) in the state of Kentucky. Forecasts help…

The United States is experiencing an opioid epidemic, and there were more than 10 million opioid misusers aged 12 or older each year. Identifying patients at high risk of Opioid Use Disorder (OUD) can help to make early clinical…

We describe two recently proposed machine learning approaches for discovering emerging trends in fatal accidental drug overdoses. The Gaussian Process Subset Scan enables early detection of emerging patterns in spatio-temporal data,…

Computers and Society · Computer Science 2017-10-09 Daniel B. Neill , William Herlands

Overdose related to prescription opioids have reached an epidemic level in the US, creating an unprecedented national crisis. This has been exacerbated partly due to the lack of tools for physicians to help predict the risk of whether a…

Opioids are an effective analgesic for acute and chronic pain, but also carry a considerable risk of addiction leading to millions of opioid use disorder (OUD) cases and tens of thousands of premature deaths in the United States yearly.…

Quantitative Methods · Quantitative Biology 2024-03-27 Sybille Légitime , Kaustubh Prabhu , Devin McConnell , Bing Wang , Dipak K. Dey , Derek Aguiar

COVID-19 has had a large scale negative impact on the health of opioid users exacerbating the health of an already vulnerable population. Critical information on the total impact of COVID-19 on opioid users is unknown due to a lack of…

Statistics Theory · Mathematics 2025-03-24 Cyen J. Peterkin , Lance A. Waller , Emily N. Peterson

The opioid crisis remains one of the most daunting and complex public health problems in the United States. This study investigates the national epidemic by analyzing vulnerability profiles of three key factors: opioid-related mortality…

Opioid Use Disorder (OUD) is a public health crisis costing the US billions of dollars annually in healthcare, lost workplace productivity, and crime. Analyzing longitudinal healthcare data is critical in addressing many real-world problems…

Substance use is a global issue that negatively impacts millions of persons who use drugs (PWUDs). In practice, identifying vulnerable PWUDs for efficient allocation of appropriate resources is challenging due to their complex use patterns…

Opioid overdose rates have increased in the United States over the past decade and reflect a major public health crisis. Modeling and prediction of drug and opioid hotspots, where a high percentage of events fall in a small percentage of…

Machine Learning · Statistics 2023-02-14 Xueying Liu , Jeremy Carter , Brad Ray , George Mohler

Accurate mortality modeling is central to actuarial science and public health, especially as mental health emerges as a significant factor in population outcomes. This paper develops and applies a Bayesian hierarchical model to analyze U.S.…

As COVID-19 spread through the United States in 2020, states began to set up alert systems to inform policy decisions and serve as risk communication tools for the general public. Many of these systems, like in Ohio, included indicators…

Applications · Statistics 2023-05-12 David Kline , Ayaz Hyder , Enhao Liu , Michael Rayo , Samuel Malloy , Elisabeth Root
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