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Related papers: Processing-in-memory for genomics workloads

200 papers

Our ISCA 2015 paper provides a new programmable processing-in-memory (PIM) architecture and system design that can accelerate key data-intensive applications, with a focus on graph processing workloads. Our major idea was to completely…

Hardware Architecture · Computer Science 2023-06-28 Junwhan Ahn , Sungpack Hong , Sungjoo Yoo , Onur Mutlu , Kiyoung Choi

Genomic signal processing has been used successfully in bioinformatics to analyze biomolecular sequences and gain varied insights into DNA structure, gene organization, protein binding, sequence evolution, etc. But challenges remain in…

Genomics · Quantitative Biology 2022-11-04 Saish Jaiswal , Shreya Nema , Hema A Murthy , Manikandan Narayanan

Advances in genome sequencing technologies generate massive amounts of sequence data that are increasingly analyzed and shared through public repositories. On-demand infrastructure services on cloud computing platforms enable the processing…

Distributed, Parallel, and Cluster Computing · Computer Science 2025-03-20 Junseok Park , Eduardo A. Maury , Changhoon Oh , Donghoon Shin , Danielle Denisko , Eunjung Alice Lee

High-throughput imaging workflows, such as Parallel Rapid Imaging with Spectroscopic Mapping (PRISM), generate data at rates that exceed conventional real-time processing capabilities. We present a scalable FPGA-based preprocessing pipeline…

Hardware Architecture · Computer Science 2025-11-26 Weichien Liao

Digital processing-in-memory (PIM) architectures mitigate the memory wall problem by facilitating parallel bitwise operations directly within the memory. Recent works have demonstrated their algorithmic potential for accelerating…

Hardware Architecture · Computer Science 2024-10-01 Orian Leitersdorf , Ronny Ronen , Shahar Kvatinsky

Biosciences have been revolutionized by next generation sequencing (NGS) technologies in last years, leading to new perspectives in medical, industrial and environmental applications. And although our motivation comes from biosciences, the…

Distributed, Parallel, and Cluster Computing · Computer Science 2017-01-16 Bruno Dantas , Calmenelias Fleitas , Alexandre P. Francisco , José Simão , Cátia Vaz

Transformers, while revolutionary, face challenges due to their demanding computational cost and large data movement. To address this, we propose HyFlexPIM, a novel mixed-signal processing-in-memory (PIM) accelerator for inference that…

Hardware Architecture · Computer Science 2025-06-03 Chang Eun Song , Priyansh Bhatnagar , Zihan Xia , Nam Sung Kim , Tajana Rosing , Mingu Kang

Bioinformatics research is characterized by voluminous and incremental datasets and complex data analytics methods. The machine learning methods used in bioinformatics are iterative and parallel. These methods can be scaled to handle big…

Computational Engineering, Finance, and Science · Computer Science 2015-06-17 Hirak Kashyap , Hasin Afzal Ahmed , Nazrul Hoque , Swarup Roy , Dhruba Kumar Bhattacharyya

Analyzing a functional genomics experiment, such as ATAC-, ChIP- or RNA-sequencing, requires reference data including a genome assembly and gene annotation. These resources can generally be retrieved from different organizations and in…

Genomics · Quantitative Biology 2022-09-05 Siebren Frölich , Maarten van der Sande , Tilman Schäfers , Simon J. van Heeringen

Database Management Systems (DBMSs) are crucial for efficient data management and analytics, and are used in several different application domains. Due to the increasing volume of data a DBMS deals with, current processor-centric…

Hardware Architecture · Computer Science 2025-04-03 Manos Frouzakis , Juan Gómez-Luna , Geraldo F. Oliveira , Mohammad Sadrosadati , Onur Mutlu

Genomic data sets are growing dramatically as the cost of sequencing continues to decline and small sequencing devices become available. Enormous community databases store and share this data with the research community, but some of these…

Processing In Memory (PIM) accelerators are promising architecture that can provide massive parallelization and high efficiency in various applications. Such architectures can instantaneously provide ultra-fast operation over extensive…

Hardware Architecture · Computer Science 2022-07-26 Kazi Abu Zubair , Sumit Kumar Jha , David Mohaisen , Clayton Hughes , Amro Awad

The performance bottleneck of deep-learning-based recommender systems resides in their backbone Deep Neural Networks. By integrating Processing-In-Memory~(PIM) architectures, researchers can reduce data movement and enhance energy…

Hardware Architecture · Computer Science 2025-05-19 Feng Cheng , Tunhou Zhang , Junyao Zhang , Jonathan Hao-Cheng Ku , Yitu Wang , Xiaoxuan Yang , Hai , Li , Yiran Chen

Next-generation sequencing (NGS) is a pivotal technique in genome sequencing due to its high throughput, rapid results, cost-effectiveness, and enhanced accuracy. Its significance extends across various domains, playing a crucial role in…

Genomics · Quantitative Biology 2025-04-28 Fathima Nuzla Ismail , Shanika Amarasoma

Data compression plays an important role to deal with high volumes of DNA sequences in the field of Bioinformatics. Again data compression techniques directly affect the alignment of DNA sequences. So the time needed to decompress a…

Computational Engineering, Finance, and Science · Computer Science 2012-11-13 Subhankar Roy , Sunirmal Khatua , Sudipta Roy , Samir K. Bandyopadhyay

With small-scale quantum processors transitioning from experimental physics labs to industrial products, these processors allow us to efficiently compute important algorithms in various fields. In this paper, we propose a quantum algorithm…

Quantum Physics · Physics 2020-05-22 Aritra Sarkar , Zaid Al-Ars , Carmen G. Almudever , Koen Bertels

Nowadays, data-intensive applications are gaining popularity and, together with this trend, processing-in-memory (PIM)-based systems are being given more attention and have become more relevant. This paper describes an analytical modeling…

Hardware Architecture · Computer Science 2021-07-23 Ronny Ronen , Adi Eliahu , Orian Leitersdorf , Natan Peled , Kunal Korgaonkar , Anupam Chattopadhyay , Ben Perach , Shahar Kvatinsky

Recent advances in machine learning (ML) have spotlighted the pressing need for computing architectures that bridge the gap between memory bandwidth and processing power. The advent of deep neural networks has pushed traditional Von Neumann…

Hardware Architecture · Computer Science 2024-07-12 Febin Sunny , Amin Shafiee , Abhishek Balasubramaniam , Mahdi Nikdast , Sudeep Pasricha

With the rapid growth of deep neural networks (DNNs), compute-in-memory (CIM) has emerged as a promising energy-efficient paradigm for accelerating multiply-and-accumulate (MAC) operations. Yet, current CIM architectures are largely limited…

Hardware Architecture · Computer Science 2026-04-16 Subhradip Chakraborty , Ankur Singh , Akhilesh R. Jaiswal

Quantum circuit simulations are essential for the verification of quantum algorithms on behalf of real quantum devices. However, the memory requirements for such simulations grow exponentially with the number of qubits involved in quantum…

Quantum Physics · Physics 2025-03-04 Dongin Lee , Enhyeok Jang , Seungwoo Choi , Junwoong An , Cheolhwan Kim , Won Woo Ro