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Contrastive learning has recently attracted plenty of attention in deep graph clustering for its promising performance. However, complicated data augmentations and time-consuming graph convolutional operation undermine the efficiency of…

Machine Learning · Computer Science 2022-06-28 Yue Liu , Xihong Yang , Sihang Zhou , Xinwang Liu

This paper presents a new, parallel implementation of clustering and demonstrates its utility in greatly speeding up the process of identifying homologous proteins. Clustering is a technique to reduce the number of comparison needed to find…

Distributed, Parallel, and Cluster Computing · Computer Science 2019-08-29 Stuart Byma , Akash Dhasade , Adrian Altenhoff , Christophe Dessimoz , James R. Larus

Unsupervised learning of disease subtypes from multi-omics data presents a significant opportunity for advancing personalized medicine. We introduce OmicsCL, a modular contrastive learning framework that jointly embeds heterogeneous omics…

Machine Learning · Computer Science 2025-05-02 Atahan Karagoz

Background. Clustering analysis discovers hidden structures in a data set by partitioning them into disjoint clusters. Robust accuracy measures that evaluate the goodness of clustering results are critical for algorithm development and…

Machine Learning · Computer Science 2021-09-06 Navid Ahmadinejad , Li Liu

Spectral clustering is one of the fundamental unsupervised learning methods widely used in data analysis. Sparse spectral clustering (SSC) imposes sparsity to the spectral clustering and it improves the interpretability of the model. This…

Machine Learning · Statistics 2020-11-03 Zhongruo Wang , Bingyuan Liu , Shixiang Chen , Shiqian Ma , Lingzhou Xue , Hongyu Zhao

Feature quality is paramount for classification performance, particularly in few-shot scenarios. Contrastive learning, a widely adopted technique for enhancing feature quality, leverages sample relations to extract intrinsic features that…

Computer Vision and Pattern Recognition · Computer Science 2025-01-24 Guowei Yin , Sheng Huang , Luwen Huangfu , Yi Zhang , Xiaohong Zhang

We propose a framework for sequence-to-sequence contrastive learning (SeqCLR) of visual representations, which we apply to text recognition. To account for the sequence-to-sequence structure, each feature map is divided into different…

Computer Vision and Pattern Recognition · Computer Science 2020-12-22 Aviad Aberdam , Ron Litman , Shahar Tsiper , Oron Anschel , Ron Slossberg , Shai Mazor , R. Manmatha , Pietro Perona

Multi-view clustering has shown to be an effective method for analyzing underlying patterns in multi-view data. The performance of clustering can be improved by learning the consistency and complementarity between multi-view features,…

Computer Vision and Pattern Recognition · Computer Science 2025-08-20 Shihao Dong , Yuhui Zheng , Huiying Xu , Xinzhong Zhu

Considering the instance-level discriminative ability, contrastive learning methods, including MoCo and SimCLR, have been adapted from the original image representation learning task to solve the self-supervised skeleton-based action…

Computer Vision and Pattern Recognition · Computer Science 2024-10-02 Mengyuan Liu , Hong Liu , Tianyu Guo

Single-cell RNA sequencing (scRNA-seq) has the potential to provide powerful, high-resolution signatures to inform disease prognosis and precision medicine. This paper takes an important first step towards this goal by developing an…

Quantitative Methods · Quantitative Biology 2021-10-15 Bryan He , Matthew Thomson , Meena Subramaniam , Richard Perez , Chun Jimmie Ye , James Zou

Contrastive learning is a powerful self-supervised learning method, but we have a limited theoretical understanding of how it works and why it works. In this paper, we prove that contrastive learning with the standard InfoNCE loss is…

Machine Learning · Computer Science 2024-02-26 Zhiquan Tan , Yifan Zhang , Jingqin Yang , Yang Yuan

According to the National Cancer Institute, there were 9.5 million cancer-related deaths in 2018. A challenge in improving treatment is resistance in genetically unstable cells. The purpose of this study is to evaluate unsupervised machine…

Genomics · Quantitative Biology 2021-08-12 Anastasia Dunca , Frederick R. Adler

Recently, various contrastive learning techniques have been developed to categorize time series data and exhibit promising performance. A general paradigm is to utilize appropriate augmentations and construct feasible positive samples such…

Machine Learning · Computer Science 2024-10-11 Qianying Ren , Dongsheng Luo , Dongjin Song

Understanding causal heterogeneity is essential for scientific discovery in domains such as biology and medicine. However, existing methods lack causal awareness, with insufficient modeling of heterogeneity, confounding, and observational…

Machine Learning · Computer Science 2025-10-29 Wenrui Li , Qinghao Zhang , Xiaowo Wang

Self-supervised learning (SSL) is a method that learns the data representation by utilizing supervision inherent in the data. This learning method is in the spotlight in the drug field, lacking annotated data due to time-consuming and…

Biomolecules · Quantitative Biology 2022-08-19 Kisung Moon , Sunyoung Kwon

In the face of rapidly accumulating genomic data, our understanding of the RNA regulatory code remains incomplete. Recent self-supervised methods in other domains have demonstrated the ability to learn rules underlying the data-generating…

Machine Learning · Computer Science 2023-10-18 Philip Fradkin , Ruian Shi , Bo Wang , Brendan Frey , Leo J. Lee

Contrastive learning is an efficient approach to self-supervised representation learning. Although recent studies have made progress in the theoretical understanding of contrastive learning, the investigation of how to characterize the…

Machine Learning · Computer Science 2023-08-21 Hiroki Waida , Yuichiro Wada , Léo Andéol , Takumi Nakagawa , Yuhui Zhang , Takafumi Kanamori

In this paper, we study contrastive learning from an optimization perspective, aiming to analyze and address a fundamental issue of existing contrastive learning methods that either rely on a large batch size or a large dictionary of…

Machine Learning · Computer Science 2022-09-22 Zhuoning Yuan , Yuexin Wu , Zi-Hao Qiu , Xianzhi Du , Lijun Zhang , Denny Zhou , Tianbao Yang

Universal, transferable whole-slide image (WSI) representations are central to computational pathology. Incorporating multiple markers (e.g., immunohistochemistry, IHC) alongside H&E enriches H&E-based features with diverse, biologically…

Computer Vision and Pattern Recognition · Computer Science 2025-12-04 Yizhi Zhang , Lei Fan , Zhulin Tao , Donglin Di , Yang Song , Sidong Liu , Cong Cong

Background: Single-cell RNA sequencing (scRNA-seq) yields valuable insights about gene expression and gives critical information about complex tissue cellular composition. In the analysis of single-cell RNA sequencing, the annotations of…

Genomics · Quantitative Biology 2023-03-29 Xiaowen Cao , Li Xing , Elham Majd , Hua He , Junhua Gu , Xuekui Zhang