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Direct Preference Optimization (DPO) has been successfully used to align large language models (LLMs) according to human preferences, and more recently it has also been applied to improving the quality of text-to-image diffusion models.…

Computer Vision and Pattern Recognition · Computer Science 2025-10-07 Shivanshu Shekhar , Shreyas Singh , Tong Zhang

Preference optimization (PO) is indispensable for large language models (LLMs), with methods such as direct preference optimization (DPO) and proximal policy optimization (PPO) achieving great success. A common belief is that DPO is…

Machine Learning · Computer Science 2026-05-18 Yue Wang , Qizhou Wang , Zizhuo Zhang , Gang Niu , Bo Han , Masashi Sugiyama

Computational protein design has a wide variety of applications. Despite its remarkable success, designing a protein for a given structure and function is still a challenging task. On the other hand, the number of solved protein structures…

Quantitative Methods · Quantitative Biology 2018-04-26 Jingxue Wang , Huali Cao , John Z. H. Zhang , Yifei Qi

Effective training of language models (LMs) for mathematical reasoning tasks demands high-quality supervised fine-tuning data. Besides obtaining annotations from human experts, a common alternative is sampling from larger and more powerful…

Computation and Language · Computer Science 2024-07-26 Tianduo Wang , Shichen Li , Wei Lu

Direct Preference Optimization (DPO) has emerged as a predominant alignment method for diffusion models, facilitating off-policy training without explicit reward modeling. However, its reliance on large-scale, high-quality human preference…

Computer Vision and Pattern Recognition · Computer Science 2026-02-09 Khiem Pham , Quang Nguyen , Tung Nguyen , Jingsen Zhu , Michele Santacatterina , Dimitris Metaxas , Ramin Zabih

Direct preference optimization (DPO) has shown success in aligning diffusion models with human preference. Previous approaches typically assume a consistent preference label between final generations and noisy samples at intermediate steps,…

Machine Learning · Computer Science 2025-02-05 Jie Ren , Yuhang Zhang , Dongrui Liu , Xiaopeng Zhang , Qi Tian

Recent advancements in reinforcement learning from human feedback have shown that utilizing fine-grained token-level reward models can substantially enhance the performance of Proximal Policy Optimization (PPO) in aligning large language…

Machine Learning · Computer Science 2025-06-18 Mingkang Zhu , Xi Chen , Zhongdao Wang , Bei Yu , Hengshuang Zhao , Jiaya Jia

In this paper, we introduce \emph{refined Direct Preference Optimization} (rDPO), a method for improving the behavioral alignment of Large Language Models (LLMs) without the need for human-annotated data. The method involves creating…

Computation and Language · Computer Science 2024-02-14 Víctor Gallego

Post-training alignment of large language models (LLMs) is a critical challenge, as not all tokens contribute equally to model performance. This paper introduces a selective alignment strategy that prioritizes high-impact tokens within…

Computation and Language · Computer Science 2025-07-11 Zhijin Dong

Direct Preference Optimization (DPO) has become a widely used training method for the instruction fine-tuning of large language models (LLMs). In this work, we explore an under-investigated aspect of DPO - its dependency on the reference…

Computation and Language · Computer Science 2024-08-23 Yixin Liu , Pengfei Liu , Arman Cohan

Direct Preference Optimization (DPO) has emerged as an important approach for learning from human preferences in aligning large language models (LLMs). However, collecting human preference data is costly and inefficient, motivating methods…

Computation and Language · Computer Science 2025-12-01 Jiacheng Guo , Zihao Li , Jiahao Qiu , Yue Wu , Mengdi Wang

Direct Preference Optimization (DPO) has emerged as a lightweight and effective alternative to Reinforcement Learning from Human Feedback (RLHF) and Reinforcement Learning with AI Feedback (RLAIF) for aligning large language and…

Artificial Intelligence · Computer Science 2025-12-16 Zihui Zhao , Zechang Li

The next token prediction loss is the dominant self-supervised training objective for large language models and has achieved promising results in a variety of downstream tasks. However, upon closer investigation of this objective, we find…

Computation and Language · Computer Science 2025-02-25 Zhili Feng , Dhananjay Ram , Cole Hawkins , Aditya Rawal , Jinman Zhao , Sheng Zha

LLM generated code often contains security issues. We address two key challenges in improving secure code generation. First, obtaining high quality training data covering a broad set of security issues is critical. To address this, we…

Cryptography and Security · Computer Science 2025-09-11 Mohammad Saqib Hasan , Saikat Chakraborty , Santu Karmaker , Niranjan Balasubramanian

Direct Preference Optimization (DPO) aligns language models using pairwise preference comparisons, offering a simple and effective alternative to Reinforcement Learning (RL) from human feedback. However, in many practical settings, training…

Machine Learning · Computer Science 2026-05-11 Ning Liu , Chuanneng Sun , Kristina Klinkner , Shervin Malmasi

Multi-label classification (MLC) often suffers from performance disparities across labels. We propose \textbf{FairPO}, a framework combining preference-based loss and group-robust optimization to improve fairness by targeting…

Machine Learning · Computer Science 2025-12-01 Soumen Kumar Mondal , Prateek Chanda , Akshit Varmora , Ganesh Ramakrishnan

Aligning large language models (LLMs) with human preferences in federated learning (FL) is challenging due to decentralized, privacy-sensitive, and highly non-IID preference data. Direct Preference Optimization (DPO) offers an efficient…

Machine Learning · Computer Science 2026-03-23 Kewen Zhu , Liping Yi , Zhiming Zhao , Zhuang Qi , Han Yu , Qinghua Hu

Direct Preference Optimization (DPO) has become a popular method for fine-tuning large language models (LLMs) due to its stability and simplicity. However, it is also known to be sensitive to noise in the data and prone to overfitting.…

Machine Learning · Computer Science 2025-10-28 Cheol Woo Kim , Shresth Verma , Mauricio Tec , Milind Tambe

Traditional preference tuning methods for LLMs/Visual Generative Models often rely solely on reward model labeling, which can be opaque, offer limited insights into the rationale behind preferences, and are prone to issues such as reward…

Machine Learning · Computer Science 2026-01-13 Hanyang Zhao , Haoxian Chen , Yucheng Guo , Genta Indra Winata , Tingting Ou , Ziyu Huang , David D. Yao , Wenpin Tang

Proteins are the fundamental macromolecules that play diverse and crucial roles in all living matter and have tremendous implications in healthcare, manufacturing, and biotechnology. Their functions are largely determined by the sequences…

Biomolecules · Quantitative Biology 2024-09-17 Boqiao Lai
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