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Background: Ontologies are fundamental components of informatics infrastructure in domains such as biomedical, environmental, and food sciences, representing consensus knowledge in an accurate and computable form. However, their…

Retrieval-Augmented Generation (RAG) methods augment the input of Large Language Models (LLMs) with relevant retrieved passages, reducing factual errors in knowledge-intensive tasks. However, contemporary RAG approaches suffer from…

Computation and Language · Computer Science 2024-05-24 Dian Jiao , Li Cai , Jingsheng Huang , Wenqiao Zhang , Siliang Tang , Yueting Zhuang

Recent advances in large language models (LLMs) have fueled the vision of automated scientific discovery, often called AI Co-Scientists. To date, prior work casts these systems as generative co-authors responsible for crafting hypotheses,…

Computation and Language · Computer Science 2025-05-20 Guijin Son , Jiwoo Hong , Honglu Fan , Heejeong Nam , Hyunwoo Ko , Seungwon Lim , Jinyeop Song , Jinha Choi , Gonçalo Paulo , Youngjae Yu , Stella Biderman

Terpenoids are a crucial class of natural products that have been studied for over 150 years, but their interdisciplinary nature (spanning chemistry, pharmacology, and biology) complicates knowledge integration. To address this, the authors…

Information Retrieval · Computer Science 2025-05-28 Xu Kang , Siqi Jiang , Kangwei Xu , Jiahao Li , Ruibo Wu

Large language models (LLMs) have recently become the leading source of answers for users' questions online. Despite their ability to offer eloquent answers, their accuracy and reliability can pose a significant challenge. This is…

Computation and Language · Computer Science 2024-07-09 Bojana Bašaragin , Adela Ljajić , Darija Medvecki , Lorenzo Cassano , Miloš Košprdić , Nikola Milošević

As the volume of published scholarly literature continues to grow, finding relevant literature becomes increasingly difficult. With the rise of generative Artificial Intelligence (AI), and particularly Large Language Models (LLMs), new…

Information Retrieval · Computer Science 2025-12-19 Allard Oelen , Mohamad Yaser Jaradeh , Sören Auer

Retrieval-Augmented Generation (RAG) encounters efficiency challenges when scaling to massive knowledge bases while preserving contextual relevance. We propose Hash-RAG, a framework that integrates deep hashing techniques with systematic…

Information Retrieval · Computer Science 2025-06-04 Jinyu Guo , Xunlei Chen , Qiyang Xia , Zhaokun Wang , Jie Ou , Libo Qin , Shunyu Yao , Wenhong Tian

The integration of retrieval-augmented techniques with LLMs has shown promise in improving performance across various domains. However, their utility in tasks requiring advanced reasoning, such as generating and evaluating mathematical…

Artificial Intelligence · Computer Science 2024-12-24 Majd Zayyad , Yossi Adi

Introduction: Generative artificial intelligence (AI), particularly large language models (LLMs), holds significant promise for Health Economics and Outcomes Research (HEOR). However, standardized reporting guidance for LLM-assisted…

Computers and Society · Computer Science 2025-06-09 Rachael L. Fleurence , Dalia Dawoud , Jiang Bian , Mitchell K. Higashi , Xiaoyan Wang , Hua Xu , Jagpreet Chhatwal , Turgay Ayer

This paper presents the development of an AI powered software platform that leverages advanced large language models (LLMs) to transform technology scouting and solution discovery in industrial R&D. Traditional approaches to solving complex…

Artificial Intelligence · Computer Science 2025-11-28 Manish Verma , Vivek Sharma , Vishal Singh

Large Language Models (LLMs) demonstrate remarkable capabilities but remain limited by their reliance on static training data. Retrieval-Augmented Generation (RAG) addresses this constraint by retrieving external knowledge during inference,…

Computation and Language · Computer Science 2026-02-19 Xingda Lyu , Gongfu Lyu , Zitai Yan , Yuxin Jiang

While Retrieval-Augmented Generation (RAG) has been swiftly adopted in scientific and clinical QA systems, a comprehensive evaluation benchmark in the medical domain is lacking. To address this gap, we introduce the Medical…

Computation and Language · Computer Science 2026-02-12 Liz Li , Wei Zhu

Recent advancements in large language models (LLMs) and multi-modal LLMs have been remarkable. However, these models still rely solely on their parametric knowledge, which limits their ability to generate up-to-date information and…

Artificial Intelligence · Computer Science 2025-04-22 Zihan Ling , Zhiyao Guo , Yixuan Huang , Yi An , Shuai Xiao , Jinsong Lan , Xiaoyong Zhu , Bo Zheng

The rapid evolution of artificial intelligence, particularly large language models, presents unprecedented opportunities for materials science research. We proposed and developed an AI materials scientist named MatPilot, which has shown…

Physics and Society · Physics 2024-11-14 Ziqi Ni , Yahao Li , Kaijia Hu , Kunyuan Han , Ming Xu , Xingyu Chen , Fengqi Liu , Yicong Ye , Shuxin Bai

Large Language Models (LLM) are disrupting science and research in different subjects and industries. Here we report a minimum-viable-product (MVP) web application called $\textbf{ScienceSage}$. It leverages generative artificial…

Information Retrieval · Computer Science 2025-02-27 Yong Zhang , Eric Herrison Gyamfi , Kelly Anderson , Sasha Roberts , Matt Barker

Retrieval Augmented Generation (RAG) frameworks have shown significant promise in leveraging external knowledge to enhance the performance of large language models (LLMs). However, conventional RAG methods often retrieve documents based…

Computation and Language · Computer Science 2025-04-02 Pouya Pezeshkpour , Estevam Hruschka

Gene set analysis is a mainstay of functional genomics, but it relies on curated databases of gene functions that are incomplete. Here we evaluate five Large Language Models (LLMs) for their ability to discover the common biological…

Retrieval-augmented generation (RAG) has demonstrated effectiveness in mitigating the hallucination problem of large language models (LLMs). However, the difficulty of aligning the retriever with the diverse LLMs' knowledge preferences…

Computation and Language · Computer Science 2024-07-19 Guanting Dong , Yutao Zhu , Chenghao Zhang , Zechen Wang , Zhicheng Dou , Ji-Rong Wen

The "AI Scientist" paradigm is transforming scientific research by automating key stages of the research process, from idea generation to scholarly writing. This shift is expected to accelerate discovery and expand the scope of scientific…

Human-Computer Interaction · Computer Science 2026-02-05 Keyu Zhao , Fengli Xu , Yong Li , Tie-Yan Liu

Answering multi-hop reasoning questions requires retrieving and synthesizing information from diverse sources. Large Language Models (LLMs) struggle to perform such reasoning consistently. Here we propose an approach to pinpoint and rectify…

Computation and Language · Computer Science 2024-03-01 Mansi Sakarvadia , Aswathy Ajith , Arham Khan , Daniel Grzenda , Nathaniel Hudson , André Bauer , Kyle Chard , Ian Foster
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