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Foundation models for computational pathology are expected to facilitate the development of high-performing, generalisable deep learning systems. However, in addition to biologically relevant features, current foundation models also capture…

Current multi-instance learning algorithms for pathology image analysis often require a substantial number of Whole Slide Images for effective training but exhibit suboptimal performance in scenarios with limited learning data. In clinical…

Computer Vision and Pattern Recognition · Computer Science 2024-07-16 Linhao Qu , Dingkang Yang , Dan Huang , Qinhao Guo , Rongkui Luo , Shaoting Zhang , Xiaosong Wang

Diagnosing diseases through histopathology whole slide images (WSIs) is fundamental in modern pathology but is challenged by the gigapixel scale and complexity of WSIs. Trained histopathologists overcome this challenge by navigating the…

Computer Vision and Pattern Recognition · Computer Science 2025-02-14 Fatemeh Ghezloo , Mehmet Saygin Seyfioglu , Rustin Soraki , Wisdom O. Ikezogwo , Beibin Li , Tejoram Vivekanandan , Joann G. Elmore , Ranjay Krishna , Linda Shapiro

Hard-label black-box attacks, relying solely on top-1 predictions, represent one of the most challenging yet practically threat models. Despite recent progress, existing approaches face two key limitations: (1) they overlook the critical…

Machine Learning · Computer Science 2026-05-25 Jun Liu , Leo Yu Zhang , Fengpeng Li , Isao Echizen , Jiantao Zhou

Microscopic interpretation of histopathology images underlies many important diagnostic and treatment decisions. While advances in vision-language modeling raise new opportunities for analysis of such images, the gigapixel-scale size of…

Diffusion models are vulnerable to backdoor attacks, where malicious attackers inject backdoors by poisoning certain training samples during the training stage. This poses a significant threat to real-world applications in the…

Cryptography and Security · Computer Science 2025-02-05 Zihan Guan , Mengxuan Hu , Sheng Li , Anil Vullikanti

As machine learning (ML) systems expand in both scale and functionality, the security landscape has become increasingly complex, with a proliferation of attacks and defenses. However, existing studies largely treat these threats in…

Cryptography and Security · Computer Science 2026-03-27 Zhenyi Wang , Siyu Luan

In computational pathology, multiple instance learning (MIL) is widely used to circumvent the computational impasse in giga-pixel whole slide image (WSI) analysis. It usually consists of two stages: patch-level feature extraction and…

Image and Video Processing · Electrical Eng. & Systems 2023-09-21 Beidi Zhao , Wenlong Deng , Zi Han , Li , Chen Zhou , Zuhua Gao , Gang Wang , Xiaoxiao Li

Computational pathology can lead to saving human lives, but models are annotation hungry and pathology images are notoriously expensive to annotate. Self-supervised learning has shown to be an effective method for utilizing unlabeled data,…

Computer Vision and Pattern Recognition · Computer Science 2023-04-19 Mingu Kang , Heon Song , Seonwook Park , Donggeun Yoo , Sérgio Pereira

From self-supervised, vision-only models to contrastive visual-language frameworks, computational pathology has rapidly evolved in recent years. Generative AI "co-pilots" now demonstrate the ability to mine subtle, sub-visual tissue cues…

Computer Vision and Pattern Recognition · Computer Science 2025-02-13 Mohsin Bilal , Aadam , Manahil Raza , Youssef Altherwy , Anas Alsuhaibani , Abdulrahman Abduljabbar , Fahdah Almarshad , Paul Golding , Nasir Rajpoot

The complexity and variability inherent in high-resolution pathological images present significant challenges in computational pathology. While pathology foundation models leveraging AI have catalyzed transformative advancements, their…

Foundation models pretrained on large-scale datasets are revolutionizing the field of computational pathology (CPath). The generalization ability of foundation models is crucial for the success in various downstream clinical tasks. However,…

Even foundational models that are trained on datasets with billions of data samples may develop shortcuts that lead to overfitting and bias. Shortcuts are non-relevant patterns in data, such as the background color or color intensity. So,…

Deep learning has led to remarkable advancements in computational histopathology, e.g., in diagnostics, biomarker prediction, and outcome prognosis. Yet, the lack of annotated data and the impact of batch effects, e.g., systematic technical…

Machine Learning · Computer Science 2024-11-11 Jonah Kömen , Hannah Marienwald , Jonas Dippel , Julius Hense

Artificial intelligence (AI) has transformed digital pathology by enabling biomarker prediction from high-resolution whole-slide images (WSIs). However, current methods are computationally inefficient, processing thousands of redundant…

Deep neural network models are massively deployed on a wide variety of hardware platforms. This results in the appearance of new attack vectors that significantly extend the standard attack surface, extensively studied by the adversarial…

Cryptography and Security · Computer Science 2022-10-03 Kevin Hector , Mathieu Dumont , Pierre-Alain Moellic , Jean-Max Dutertre

Despite remarkable efforts been made, the classification of gigapixels whole-slide image (WSI) is severely restrained from either the constrained computing resources for the whole slides, or limited utilizing of the knowledge from different…

Computer Vision and Pattern Recognition · Computer Science 2022-07-13 Ming Feng , Kele Xu , Nanhui Wu , Weiquan Huang , Yan Bai , Changjian Wang , Huaimin Wang

In this work, besides improving prediction accuracy, we study whether personalization could bring robustness benefits to backdoor attacks. We conduct the first study of backdoor attacks in the pFL framework, testing 4 widely used backdoor…

Machine Learning · Computer Science 2023-06-06 Zeyu Qin , Liuyi Yao , Daoyuan Chen , Yaliang Li , Bolin Ding , Minhao Cheng

Digital pathology has revolutionized the field by enabling the digitization of tissue samples into whole slide images (WSIs). However, the high resolution and large size of WSIs present significant challenges when it comes to applying Deep…

Computer Vision and Pattern Recognition · Computer Science 2025-07-03 Ali Mammadov , Loïc Le Folgoc , Guillaume Hocquet , Pietro Gori

The field of computational pathology has been transformed with recent advances in foundation models that encode histopathology region-of-interests (ROIs) into versatile and transferable feature representations via self-supervised learning…