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We present assembly-theory, a Rust package for computing assembly indices of covalently bonded molecular structures. This is a key complexity measure of assembly theory, a recent theoretical framework quantifying selection across diverse…

How do we estimate the probability of an abundant objects' formation, with minimal context or assumption about is origin? To explore this we have previously introduced the concept of pathway assembly (as pathway complexity), in a graph…

Information Theory · Computer Science 2018-04-20 Alastair Murray , Stuart Marshall , Leroy Cronin

Assembly theory (AT) quantifies selection using the assembly equation and identifies complex objects that occur in abundance based on two measurements, assembly index and copy number, where the assembly index is the minimum number of…

The sequence in which a complex product is assembled directly impacts the ease and efficiency of the assembly process, whether executed by a human or a robot. A sequence that gives the assembler the greatest freedom of movement is therefore…

Robotics · Computer Science 2019-07-10 James Watson , Tucker Hermans

This paper addresses the problem of reassembling images from disjointed fragments. More specifically, given an unordered set of fragments, we aim at reassembling one or several possibly incomplete images. The main contributions of this work…

Computer Vision and Pattern Recognition · Computer Science 2018-09-05 M. -M. Paumard , D. Picard , H. Tabia

We introduce a new concept of a subgraph class called a superbubble for analyzing assembly graphs, and propose an efficient algorithm for detecting it. Most assembly algorithms utilize assembly graphs like the de Bruijn graph or the overlap…

Data Structures and Algorithms · Computer Science 2013-08-02 Taku Onodera , Kunihiko Sadakane , Tetsuo Shibuya

Large protein complexes are assembled from protein subunits to form a specific structure. In our theoretic work, we propose that assembly into the correct structure could be reliably achieved through an assembly line with a specific…

Biological Physics · Physics 2022-03-23 Tyler S. Harmon , Frank Jülicher

Assembly planning is the core of automating product assembly, maintenance, and recycling for modern industrial manufacturing. Despite its importance and long history of research, planning for mechanical assemblies when given the final…

Robotics · Computer Science 2022-11-09 Yunsheng Tian , Jie Xu , Yichen Li , Jieliang Luo , Shinjiro Sueda , Hui Li , Karl D. D. Willis , Wojciech Matusik

We demonstrate that the assembly pathway method underlying assembly theory (AT) is an encoding scheme widely used by popular statistical compression algorithms. We show that in all cases (synthetic or natural) AT performs similarly to other…

Information Theory · Computer Science 2024-08-15 Abicumaran Uthamacumaran , Felipe S. Abrahão , Narsis A. Kiani , Hector Zenil

Molecule generation is central to a variety of applications. Current attention has been paid to approaching the generation task as subgraph prediction and assembling. Nevertheless, these methods usually rely on hand-crafted or external…

Machine Learning · Computer Science 2022-12-20 Xiangzhe Kong , Wenbing Huang , Zhixing Tan , Yang Liu

Graphs are used to represent and analyze data in domains as diverse as physics, biology, chemistry, planetary science, and the social sciences. Across domains, random graph models relate generative processes to expected graph properties,…

Physics and Society · Physics 2025-09-12 Cole Mathis , Harrison B. Smith

The assembly index of assembly theory quantifies the minimal number of composition steps required to construct an object from elementary components. The study proves that the decision version of the assembly index problem is NP-complete,…

Computational Complexity · Computer Science 2026-04-21 Piotr Masierak

We introduce a simple dynamical rule in which each particle locates a particle that is farthest from it and moves towards it. Repeated application of this algorithm results in the formation of unusual dynamical patterns: during the process…

Dynamical Systems · Mathematics 2019-09-24 Kulveer Singh , Yitzhak Rabin

We introduce and analyze the concept of an assembly map from the original homotopy theoretic point of view. We give also interpretations in terms of surgery theory, controlled topology and index theory. The motivation is that prominent…

K-Theory and Homology · Mathematics 2019-01-03 Wolfgang Lueck

Hypergraphs, increasingly utilised for modelling complex and diverse relationships in modern networks, gain much attention representing intricate higher-order interactions. Among various challenges, cohesive subgraph discovery is one of the…

Social and Information Networks · Computer Science 2025-12-30 Song Kim , Dahee Kim , Taejoon Han , Junghoon Kim , Hyun Ji Jeong , Jungeun Kim

Rapid discovery of new reactions and molecules in recent years has been facilitated by the advancements in high throughput screening, accessibility to a much more complex chemical design space, and the development of accurate molecular…

Molecular Networks · Quantitative Biology 2023-03-28 Vipul Mann , Venkat Venkatasubramanian

We use assembly maps to study $\mathbf{TC}(\mathbb{A}[G];p)$, the topological cyclic homology at a prime $p$ of the group algebra of a discrete group $G$ with coefficients in a connective ring spectrum $\mathbb{A}$. For any finite group, we…

K-Theory and Homology · Mathematics 2019-10-02 Wolfgang Lueck , Holger Reich , John Rognes , Marco Varisco

Quantifying how hard it is to build a molecular graph matters for biosignature detection, chemical complexity, and cheminformatics. We present an exact, scalable algorithm to compute the molecular assembly index (MA) which prioritizes the…

Data Structures and Algorithms · Computer Science 2025-08-19 Ian Seet , Keith Y. Patarroyo , Gage Siebert , Sara I. Walker , Leroy Cronin

We prove the full equivalence between Assembly Theory (AT) and Shannon Entropy via a method based upon the principles of statistical compression renamed `assembly index' that belongs to the LZ family of popular compression algorithms (ZIP,…

Information Theory · Computer Science 2024-04-04 Felipe S. Abrahão , Santiago Hernández-Orozco , Narsis A. Kiani , Jesper Tegnér , Hector Zenil

A paradigm that was successfully applied in the study of both pure and algorithmic problems in graph theory can be colloquially summarized as stating that "any graph is close to being the disjoint union of expanders". Our goal in this paper…

Combinatorics · Mathematics 2015-02-03 Guy Moshkovitz , Asaf Shapira
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