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We analyze functional magnetic resonance imaging (fMRI) data from the Human Connectome Project (HCP) to match brain activities during a range of cognitive tasks. Our findings demonstrate that even basic linear machine learning models can…

Neurons and Cognition · Quantitative Biology 2025-10-08 Valeriya Kirova , Dzerassa Kadieva , Daniil Vlasenko , Isak B. Blank , Fedor Ratnikov

Graph Transformers have recently been successful in various graph representation learning tasks, providing a number of advantages over message-passing Graph Neural Networks. Utilizing Graph Transformers for learning the representation of…

Neurons and Cognition · Quantitative Biology 2023-12-27 Byung-Hoon Kim , Jungwon Choi , EungGu Yun , Kyungsang Kim , Xiang Li , Juho Lee

Investigations of the human connectome have elucidated core features of adult structural networks, particularly the crucial role of hub-regions. However, little is known regarding network organisation of the healthy elderly connectome, a…

Neurons and Cognition · Quantitative Biology 2015-12-15 Alistair Perry , Wei Wen , Anton Lord , Anbupalam Thalamuthu , Perminder Sachdev , Michael Breakspear

White matter tract segmentation is crucial for studying brain structural connectivity and neurosurgical planning. However, segmentation remains challenging due to issues like class imbalance between major and minor tracts, structural…

Computer Vision and Pattern Recognition · Computer Science 2025-01-28 Anoushkrit Goel , Bipanjit Singh , Ankita Joshi , Ranjeet Ranjan Jha , Chirag Ahuja , Aditya Nigam , Arnav Bhavsar

Large bundles of myelinated axons, called white matter, anatomically connect disparate brain regions together and compose the structural core of the human connectome. We recently proposed a method of measuring the local integrity along the…

Applications · Statistics 2018-09-18 Yo Joong Choe , Sivaraman Balakrishnan , Aarti Singh , Jean M. Vettel , Timothy Verstynen

The human connectome has been widely studied over the past decade. A principal finding is that it can be decomposed into communities of densely interconnected brain regions. This result, however, may be limited methodologically. Past…

The lack of analytical models describing diffusion time dependence at intermediate time scales in complex tissue microstructure limits the accurate quantification of extracellular diffusivity and tissue microstructure. We introduce TRACED,…

Human braingraphs or connectomes are widely studied in the last decade to understand the structural and functional properties of our brain. In the last several years our research group has computed and deposited thousands of human…

Neurons and Cognition · Quantitative Biology 2024-12-03 Balint Varga , Vince Grolmusz

Modeling the behavior of coupled networks is challenging due to their intricate dynamics. For example in neuroscience, it is of critical importance to understand the relationship between the functional neural processes and anatomical…

Machine Learning · Computer Science 2021-04-20 Hongyuan You , Sikun Lin , Ambuj K. Singh

The human brain is the most complex object of study we encounter today. Mapping the neuronal-level connections between the more than 80 billion neurons in the brain is a hopeless task for science. By the recent advancement of magnetic…

Neurons and Cognition · Quantitative Biology 2020-09-01 Balint Varga , Vince Grolmusz

We present a method combining affinity prediction with region agglomeration, which improves significantly upon the state of the art of neuron segmentation from electron microscopy (EM) in accuracy and scalability. Our method consists of a…

Computer Vision and Pattern Recognition · Computer Science 2020-07-29 Jan Funke , Fabian David Tschopp , William Grisaitis , Arlo Sheridan , Chandan Singh , Stephan Saalfeld , Srinivas C. Turaga

Diffusion MRI (dMRI) is an advanced imaging technique characterizing tissue microstructure and white matter structural connectivity of the human brain. The demand for high-quality dMRI data is growing, driven by the need for better…

Image and Video Processing · Electrical Eng. & Systems 2024-08-26 Xi Zhu , Wei Zhang , Yijie Li , Lauren J. O'Donnell , Fan Zhang

Accurately identifying white matter tracts in medical images is essential for various applications, including surgery planning and tract-specific analysis. Supervised machine learning models have reached state-of-the-art solving this task…

Image and Video Processing · Electrical Eng. & Systems 2023-08-04 Robin Peretzke , Klaus Maier-Hein , Jonas Bohn , Yannick Kirchhoff , Saikat Roy , Sabrina Oberli-Palma , Daniela Becker , Pavlina Lenga , Peter Neher

Brain network analysis plays an increasingly important role in studying brain function and the exploring of disease mechanisms. However, existing brain network construction tools have some limitations, including dependency on empirical…

Neurons and Cognition · Quantitative Biology 2024-07-29 Yongcheng Zong , Shuqiang Wang

Building comprehensive brain connectomes has proved of fundamental importance in resting-state fMRI (rs-fMRI) analysis. Based on the foundation of brain network, spatial-temporal-based graph convolutional networks have dramatically improved…

Machine Learning · Computer Science 2023-12-19 Rui Yang , Wenrui Dai , Huajun She , Yiping P. Du , Dapeng Wu , Hongkai Xiong

In this work, we explore the various Brain Neuron tracking techniques, which is one of the most significant applications of Diffusion Tensor Imaging. Tractography provides us with a non-invasive method to analyze underlying tissue…

Computer Vision and Pattern Recognition · Computer Science 2018-06-12 Nandakishore Puttashamachar , Ulas Bagci

The thalamus consists of several histologically and functionally distinct nuclei increasingly implicated in brain pathology and important for treatment, motivating the need for development of fast and accurate thalamic segmentation. The…

Image and Video Processing · Electrical Eng. & Systems 2019-12-19 Charles Iglehart , Martin Monti , Joshua Cain , Thomas Tourdias , Manojkumar Saranathan

The shape of the brain's white matter connections is relatively unexplored in diffusion MRI tractography analysis. While it is known that tract shape varies in populations and across the human lifespan, it is unknown if the variability in…

Purpose: Conventional automated segmentation of the head anatomy in MRI distinguishes different brain and non-brain tissues based on image intensities and prior tissue probability maps (TPM). This works well for normal head anatomies, but…

Image and Video Processing · Electrical Eng. & Systems 2021-05-20 Lukas Hirsch , Yu Huang , Lucas C Parra

The specificty and sensitivity of resting state functional MRI (rs-fMRI) measurements depend on pre-processing choices, such as the parcellation scheme used to define regions of interest (ROIs). In this study, we critically evaluate the…

Computer Vision and Pattern Recognition · Computer Science 2019-06-06 Meenakshi Khosla , Keith Jamison , Amy Kuceyeski , Mert R. Sabuncu