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With the growing interest in foundation models for brain signals, graph-based pretraining has emerged as a promising paradigm for learning transferable representations from connectome data. However, existing contrastive and masked…

Machine Learning · Computer Science 2026-03-10 Xinxu Wei , Rong Zhou , Lifang He , Yu Zhang

Tractography has become an indispensable part of brain connectivity studies. However, it is currently facing problems with reliability. In particular, a substantial amount of nerve fiber reconstructions (streamlines) in tractograms produced…

Computer Vision and Pattern Recognition · Computer Science 2023-07-25 Antonia Hain , Daniel Jörgens , Rodrigo Moreno

Tractography from high-dimensional diffusion magnetic resonance imaging (dMRI) data allows brain's structural connectivity analysis. Recent dMRI studies aim to compare connectivity patterns across subject groups and disease populations to…

Functional connectivity estimates are highly sensitive to analysis choices and can be dominated by noise when the number of sampled time points is small relative to network dimensionality. This issue is particularly acute in fMRI, where…

Disordered Systems and Neural Networks · Physics 2026-02-10 Izaro Fernandez-Iriondo , Antonio Jimenez-Marin , Jesus Cortes , Pablo Villegas

Diffusion MRI tractography is an important tool for identifying and analyzing the intracranial course of cranial nerves (CNs). However, the complex environment of the skull base leads to ambiguous spatial correspondence between diffusion…

Image and Video Processing · Electrical Eng. & Systems 2024-09-23 Lei Xie , Qingrun Zeng , Huajun Zhou , Guoqiang Xie , Mingchu Li , Jiahao Huang , Jianan Cui , Hao Chen , Yuanjing Feng

In mapping the human structural connectome, we are in a very fortunate situation: one can compute and compare graphs, describing the cerebral connections between the very same, anatomically identified small regions of the gray matter among…

Neurons and Cognition · Quantitative Biology 2017-12-01 Mate Fellner , Balint Varga , Vince Grolmusz

Neuroimaging measures of the brain's white matter connections can enable the prediction of non-imaging phenotypes, such as demographic and cognitive measures. Existing works have investigated traditional microstructure and connectivity…

Computer Vision and Pattern Recognition · Computer Science 2023-05-23 Wan Liu , Yuqian Chen , Chuyang Ye , Nikos Makris , Yogesh Rathi , Weidong Cai , Fan Zhang , Lauren J. O'Donnell

This manuscript presents a novel, tightly integrated pipeline for estimating a connectome, which is a comprehensive description of the neural circuits in the brain. The pipeline utilizes magnetic resonance imaging (MRI) data to produce a…

Neurons and Cognition · Quantitative Biology 2011-11-14 William R. Gray , John A. Bogovic , Joshua T. Vogelstein , Bennett A. Landman , Jerry L. Prince , R. Jacob Vogelstein

Tractography parcellation classifies streamlines reconstructed from diffusion MRI into anatomically defined fiber tracts for clinical and research applications. However, clinical scans often have incomplete fields of view (FOV) where brain…

Computer Vision and Pattern Recognition · Computer Science 2025-03-07 Yuqian Chen , Leo Zekelman , Yui Lo , Suheyla Cetin-Karayumak , Tengfei Xue , Yogesh Rathi , Nikos Makris , Fan Zhang , Weidong Cai , Lauren J. O'Donnell

Graph deep learning models, a class of AI-driven approaches employing a message aggregation mechanism, have gained popularity for analyzing the functional brain connectome in neuroimaging. However, their actual effectiveness remains…

Neural and Evolutionary Computing · Computer Science 2026-02-10 Keqi Han , Yao Su , Lifang He , Liang Zhan , Sergey Plis , Vince Calhoun , Carl Yang

Diffusion magnetic resonance imaging (dMRI) is a crucial non-invasive technique for exploring the microstructure of the living human brain. Traditional hand-crafted and model-based tissue microstructure reconstruction methods often require…

Image and Video Processing · Electrical Eng. & Systems 2025-02-26 Xinrui Ma , Jian Cheng , Wenxin Fan , Ruoyou Wu , Yongquan Ye , Shanshan Wang

Accurate brain parcellation in diffusion MRI (dMRI) space is essential for advanced neuroimaging analyses. However, most existing approaches rely on anatomical MRI for segmentation and inter-modality registration, a process that can…

Image and Video Processing · Electrical Eng. & Systems 2025-08-12 Yousef Sadegheih , Dorit Merhof

Tractography fiber clustering using diffusion MRI (dMRI) is a crucial strategy for white matter (WM) parcellation. Current methods primarily use the geometric information of fibers (i.e., the spatial trajectories) to group similar fibers…

Image and Video Processing · Electrical Eng. & Systems 2024-12-17 Jin Wang , Bocheng Guo , Yijie Li , Junyi Wang , Yuqian Chen , Jarrett Rushmore , Nikos Makris , Yogesh Rathi , Lauren J O'Donnell , Fan Zhang

High-throughput methods for yielding the set of connections in a neural system, the connectome, are now being developed. This tutorial describes ways to analyze the topological and spatial organization of the connectome at the macroscopic…

Neurons and Cognition · Quantitative Biology 2011-12-23 Marcus Kaiser

In brain connectomics, the cortical surface is parcellated into different regions of interest (ROIs) prior to statistical analysis. The brain connectome for each individual can then be represented as a graph, with the nodes corresponding to…

Methodology · Statistics 2020-10-07 Steven Winter , Zhengwu Zhang , David Dunson

Tractograms are virtual representations of the white matter fibers of the brain. They are of primary interest for tasks like presurgical planning, and investigation of neuroplasticity or brain disorders. Each tractogram is composed of…

Neurons and Cognition · Quantitative Biology 2020-07-10 Pietro Astolfi , Ruben Verhagen , Laurent Petit , Emanuele Olivetti , Jonathan Masci , Davide Boscaini , Paolo Avesani

Our understanding of the structure of the brain and its relationships with human traits is largely determined by how we represent the structural connectome. Standard practice divides the brain into regions of interest (ROIs) and represents…

Applications · Statistics 2023-06-13 Rongjie Liu , Meng Li , David B. Dunson

The state-of-the-art method for automatically segmenting white matter bundles in diffusion-weighted MRI is tractography in conjunction with streamline cluster selection. This process involves long chains of processing steps which are not…

Computer Vision and Pattern Recognition · Computer Science 2017-03-08 Jakob Wasserthal , Peter F. Neher , Fabian Isensee , Klaus H. Maier-Hein

The assessment of brain fingerprints has emerged in the recent years as an important tool to study individual differences and to infer quality of neuroimaging datasets. Studies so far have mainly focused on connectivity fingerprints between…

Neurons and Cognition · Quantitative Biology 2021-01-13 Uttara Tipnis , Kausar Abbas , Elizabeth Tran , Enrico Amico , Li Shen , Alan D. Kaplan , Joaquín Goñi

While the major white matter tracts are of great interest to numerous studies in neuroscience and medicine, their manual dissection in larger cohorts from diffusion MRI tractograms is time-consuming, requires expert knowledge and is hard to…

Computer Vision and Pattern Recognition · Computer Science 2018-06-15 Jakob Wasserthal , Peter F. Neher , Klaus H. Maier-Hein
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