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Finding frequently occurring subgraph patterns or network motifs in neural architectures is crucial for optimizing efficiency, accelerating design, and uncovering structural insights. However, as the subgraph size increases,…

Machine Learning · Computer Science 2026-02-04 Yikang Yang , Zhengxin Yang , Minghao Luo , Luzhou Peng , Hongxiao Li , Wanling Gao , Lei Wang , Jianfeng Zhan

Graph similarity is critical in graph-related tasks such as graph retrieval, where metrics like maximum common subgraph (MCS) and graph edit distance (GED) are commonly used. However, exact computations of these metrics are known to be…

Machine Learning · Computer Science 2025-10-02 Zhouyang Liu , Yixin Chen , Ning Liu , Jiezhong He , Dongsheng Li

Controllable molecular graph generation is essential for material and drug discovery, where generated molecules must satisfy diverse property constraints. While recent advances in graph diffusion models have improved generation quality,…

Machine Learning · Computer Science 2025-09-30 Anjie Qiao , Zhen Wang , Chuan Chen , DeFu Lian , Enhong Chen

Molecule generation is central to a variety of applications. Current attention has been paid to approaching the generation task as subgraph prediction and assembling. Nevertheless, these methods usually rely on hand-crafted or external…

Machine Learning · Computer Science 2022-12-20 Xiangzhe Kong , Wenbing Huang , Zhixing Tan , Yang Liu

Accurate prediction of drug-target interaction (DTI) is essential for in silico drug design. For the purpose, we propose a novel approach for predicting DTI using a GNN that directly incorporates the 3D structure of a protein-ligand…

Machine Learning · Computer Science 2019-04-18 Jaechang Lim , Seongok Ryu , Kyubyong Park , Yo Joong Choe , Jiyeon Ham , Woo Youn Kim

Entity Resolution (ER) is a constitutional part for integrating different knowledge graphs in order to identify entities referring to the same real-world object. A promising approach is the use of graph embeddings for ER in order to…

Machine Learning · Computer Science 2021-01-18 Daniel Obraczka , Jonathan Schuchart , Erhard Rahm

Predicting relaxed atomic structures of chemically complex materials remains a major computational challenge, particularly for high-entropy systems where traditional first-principles methods become prohibitively expensive. We introduce the…

Disordered Systems and Neural Networks · Physics 2025-12-09 Neethu Mohan Mangalassery , Abhishek Kumar Singh

Recent advances in molecular representation learning have produced highly effective encodings of molecules for numerous cheminformatics and bioinformatics tasks. However, extracting general chemical insight while balancing predictive…

Machine Learning · Computer Science 2025-09-26 Rahul Khorana

In recent years, AI-assisted drug design methods have been proposed to generate molecules given the pockets' structures of target proteins. Most of them are atom-level-based methods, which consider atoms as basic components and generate…

Biomolecules · Quantitative Biology 2024-03-19 Haitao Lin , Yufei Huang , Odin Zhang , Lirong Wu , Siyuan Li , Zhiyuan Chen , Stan Z. Li

Knowledge graphs (KGs) represent connections and relationships between real-world entities. We propose a link prediction framework for KGs named Enrichment-Driven GrAph Reasoner (EDGAR), which infers new edges by mining entity-local rules.…

Information Theory · Computer Science 2024-11-14 Olawumi Olasunkanmi , Evan Morris , Yaphet Kebede , Harlin Lee , Stanley Ahalt , Alexander Tropsha , Chris Bizon

In this paper we study the practicality and usefulness of incorporating distributed representations of graphs into models within the context of drug pair scoring. We argue that the real world growth and update cycles of drug pair scoring…

Machine Learning · Computer Science 2022-11-28 Paul Scherer , Pietro Liò , Mateja Jamnik

Embedding graphs in continous spaces is a key factor in designing and developing algorithms for automatic information extraction to be applied in diverse tasks (e.g., learning, inferring, predicting). The reliability of graph embeddings…

Machine Learning · Computer Science 2023-11-30 Andrea Marinoni , Pietro Lio' , Alessandro Barp , Christian Jutten , Mark Girolami

Image guided depth completion aims to recover per-pixel dense depth maps from sparse depth measurements with the help of aligned color images, which has a wide range of applications from robotics to autonomous driving. However, the 3D…

Computer Vision and Pattern Recognition · Computer Science 2022-10-20 Xin Liu , Xiaofei Shao , Bo Wang , Yali Li , Shengjin Wang

Recent electroencephalography (EEG) spatial super-resolution (SR) methods, while showing improved quality by either directly predicting missing signals from visible channels or adapting latent diffusion-based generative modeling to temporal…

Machine Learning · Computer Science 2026-02-03 Laura Yao , Gengwei Zhang , Moajjem Chowdhury , Yunmei Liu , Tianlong Chen

Graphs are widely used for describing systems made up of many interacting components and for understanding the structure of their interactions. Various statistical models exist, which describe this structure as the result of a combination…

Methodology · Statistics 2021-06-28 Louis Duvivier , Rémy Cazabet , Céline Robardet

Spatial graphs are particular graphs for which the nodes are localized in space (e.g., public transport network, molecules, branching biological structures). In this work, we consider the problem of spatial graph reduction, that aims to…

Machine Learning · Statistics 2026-03-10 Anna Calissano , Etienne Lasalle

Many real-world graphs (networks) are heterogeneous with different types of nodes and edges. Heterogeneous graph embedding, aiming at learning the low-dimensional node representations of a heterogeneous graph, is vital for various…

Social and Information Networks · Computer Science 2021-12-15 Wentao Xu , Yingce Xia , Weiqing Liu , Jiang Bian , Jian Yin , Tie-Yan Liu

Generating 3D content from a single image remains a fundamentally challenging and ill-posed problem due to the inherent absence of geometric and textural information in occluded regions. While state-of-the-art generative models can…

Computer Vision and Pattern Recognition · Computer Science 2026-02-12 Zehua Ma , Hanhui Li , Zhenyu Xie , Xiaonan Luo , Michael Kampffmeyer , Feng Gao , Xiaodan Liang

While deep learning has revolutionized the prediction of rigid protein structures, modelling the conformational ensembles of Intrinsically Disordered Proteins (IDPs) remains a key frontier. Current AI paradigms present a trade-off: Protein…

Biomolecules · Quantitative Biology 2025-12-19 Eoin Quinn , Marco Carobene , Jean Quentin , Sebastien Boyer , Miguel Arbesú , Oliver Bent

The Random Dot Product Graph (RDPG) is a generative model for relational data, where nodes are represented via latent vectors in low-dimensional Euclidean space. RDPGs crucially postulate that edge formation probabilities are given by the…

Machine Learning · Computer Science 2023-12-11 Marcelo Fiori , Bernardo Marenco , Federico Larroca , Paola Bermolen , Gonzalo Mateos