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This paper studies unsupervised/self-supervised whole-graph representation learning, which is critical in many tasks such as molecule properties prediction in drug and material discovery. Existing methods mainly focus on preserving the…

Machine Learning · Computer Science 2021-06-09 Minghao Xu , Hang Wang , Bingbing Ni , Hongyu Guo , Jian Tang

The interval Distance Geometry Problem (iDGP) consists in finding a realization in $\mathbb{R}^K$ of a simple undirected graph $G=(V,E)$ with nonnegative intervals assigned to the edges in such a way that, for each edge, the Euclidean…

Computational Geometry · Computer Science 2016-07-05 Claudia D'Ambrosio , Ky Vu , Carlile Lavor , Leo Liberti , Nelson Maculan

Minimizing adverse reactions caused by drug-drug interactions has always been a momentous research topic in clinical pharmacology. Detecting all possible interactions through clinical studies before a drug is released to the market is a…

Artificial Intelligence · Computer Science 2018-03-13 Meng Wang

Knowledge Graph Completion is a task of expanding the knowledge graph/base through estimating possible entities, or proper nouns, that can be connected using a set of predefined relations, or verb/predicates describing interconnections of…

Computation and Language · Computer Science 2021-01-25 Tong Chen , Sirou Zhu , Yiming Wen , Zhaomin Zheng

A regularized version of Mixture Models is proposed to learn a principal graph from a distribution of $D$-dimensional data points. In the particular case of manifold learning for ridge detection, we assume that the underlying manifold can…

Machine Learning · Computer Science 2023-07-13 Tony Bonnaire , Aurélien Decelle , Nabila Aghanim

In this paper, we explore an open research problem concerning the reconstruction of 3D scenes from images. Recent methods have adopt 3D Gaussian Splatting (3DGS) to produce 3D scenes due to its efficient training process. However, these…

Computer Vision and Pattern Recognition · Computer Science 2025-04-21 Beizhen Zhao , Yifan Zhou , Zijian Wang , Hao Wang

Accurately predicting drug-target interactions (DTIs) is pivotal for advancing drug discovery and target validation techniques. While machine learning approaches including those that are based on Graph Neural Networks (GNN) have achieved…

Machine Learning · Computer Science 2025-09-30 Yuehua Song , Yong Gao

Tomography medical imaging is essential in the clinical workflow of modern cancer radiotherapy. Radiation oncologists identify cancerous tissues, applying delineation on treatment regions throughout all image slices. This kind of task is…

Computer Vision and Pattern Recognition · Computer Science 2019-04-08 Chun-Hung Chao , Yen-Chi Cheng , Hsien-Tzu Cheng , Chi-Wen Huang , Tsung-Ying Ho , Chen-Kan Tseng , Le Lu , Min Sun

Cancer is the second leading cause of death, with chemotherapy as one of the primary forms of treatment. As a result, researchers are turning to drug combination therapy to decrease drug resistance and increase efficacy. Current methods of…

Quantitative Methods · Quantitative Biology 2024-11-08 Zachary Schwehr

Graph representation learning is a fast-growing field where one of the main objectives is to generate meaningful representations of graphs in lower-dimensional spaces. The learned embeddings have been successfully applied to perform various…

Machine Learning · Computer Science 2021-12-21 Md. Khaledur Rahman , Ariful Azad

Graph neural networks (GNNs) are processing architectures that exploit graph structural information to model representations from network data. Despite their success, GNNs suffer from sub-optimal generalization performance given limited…

Machine Learning · Computer Science 2021-06-08 Zhan Gao , Subhrajit Bhattacharya , Leiming Zhang , Rick S. Blum , Alejandro Ribeiro , Brian M. Sadler

Subgraph-based methods have proven to be effective and interpretable in predicting drug-drug interactions (DDIs), which are essential for medical practice and drug development. Subgraph selection and encoding are critical stages in these…

Machine Learning · Computer Science 2024-11-05 Haotong Du , Quanming Yao , Juzheng Zhang , Yang Liu , Zhen Wang

Drug synergy, characterized by the amplified combined effect of multiple drugs, is critically important for optimizing therapeutic outcomes. Limited data on drug synergy, arising from the vast number of possible drug combinations and…

Machine Learning · Computer Science 2023-11-08 Oleksii Tsepa , Bohdan Naida , Anna Goldenberg , Bo Wang

Automatic emotion recognition based on multichannel Electroencephalography (EEG) holds great potential in advancing human-computer interaction. However, several significant challenges persist in existing research on algorithmic emotion…

Machine Learning · Computer Science 2023-10-24 Hongxiang Gao , Xiangyao Wang , Zhenghua Chen , Min Wu , Zhipeng Cai , Lulu Zhao , Jianqing Li , Chengyu Liu

In recent years, deep learning based methods have shown success in essential medical image analysis tasks such as segmentation. Post-processing and refining the results of segmentation is a common practice to decrease the misclassifications…

Image and Video Processing · Electrical Eng. & Systems 2021-08-29 Ufuk Demir , Atahan Ozer , Yusuf H. Sahin , Gozde Unal

We consider the problem of embedding the nodes of a hypergraph into Euclidean space under the assumption that the interactions arose through closeness to unknown hyperedge centres. In this way, we tackle the inverse problem associated with…

Social and Information Networks · Computer Science 2025-09-11 Francesco Zigliotto , Desmond J. Higham

The dipole moment is a physical quantity indicating the polarity of a molecule and is determined by reflecting the electrical properties of constituent atoms and the geometric properties of the molecule. Most embeddings used to represent…

Machine Learning · Computer Science 2022-06-28 Yang Jeong Park

The rise of graph-structured data has driven major advances in Graph Machine Learning (GML), where graph embeddings (GEs) map features from Knowledge Graphs (KGs) into vector spaces, enabling tasks like node classification and link…

Machine Learning · Computer Science 2026-01-27 Rosario Napoli , Gabriele Morabito , Antonio Celesti , Massimo Villari , Maria Fazio

Effective molecular representation learning is of great importance to facilitate molecular property prediction, which is a fundamental task for the drug and material industry. Recent advances in graph neural networks (GNNs) have shown great…

Machine Learning · Computer Science 2022-05-17 Xiaomin Fang , Lihang Liu , Jieqiong Lei , Donglong He , Shanzhuo Zhang , Jingbo Zhou , Fan Wang , Hua Wu , Haifeng Wang

Graph embedding methods aim at finding useful graph representations by mapping nodes to a low-dimensional vector space. It is a task with important downstream applications, such as link prediction, graph reconstruction, data visualization,…

Machine Learning · Computer Science 2022-09-13 Said Kerrache , Hafida Benhidour
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