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The histological assessment of human tissue has emerged as the key challenge for detection and treatment of cancer. A plethora of different data sources ranging from tissue microarray data to gene expression, proteomics or metabolomics data…

Computer Vision and Pattern Recognition · Computer Science 2016-01-05 Thomas J. Fuchs , Joachim M. Buhmann

Mitotic figures are classified into typical and atypical variants, with atypical counts correlating strongly with tumor aggressiveness. Accurate differentiation is therefore essential for patient prognostication and resource allocation, yet…

Image and Video Processing · Electrical Eng. & Systems 2025-09-19 Mieko Ochi , Bae Yuan

Conventional histopathology has long been essential for disease diagnosis, relying on visual inspection of tissue sections. Immunohistochemistry aids in detecting specific biomarkers but is limited by its single-marker approach, restricting…

Accurate prediction of cancer progression remains a challenge due to the high heterogeneity of molecular omics data across patients. While biologically informed models have improved the interpretability of these predictions, a persistent…

Machine Learning · Computer Science 2026-04-21 Koushik Howlader , Md Tauhidul Islam , Wei Le

Foundation models pretrained on large-scale histopathology data have found great success in various fields of computational pathology, but their impact on regressive biomarker prediction remains underexplored. In this work, we…

Computer Vision and Pattern Recognition · Computer Science 2026-02-06 Alexander Blezinger , Wolfgang Nejdl , Ming Tang

Whole slide image (WSI) analysis has emerged as an increasingly essential technique in computational pathology. Recent advances in the pathology foundation models (FMs) have demonstrated significant advantages in deriving meaningful…

Computer Vision and Pattern Recognition · Computer Science 2025-11-21 Zhidong Yang , Xiuhui Shi , Wei Ba , Zhigang Song , Haijing Luan , Taiyuan Hu , Senlin Lin , Jiguang Wang , Shaohua Kevin Zhou , Rui Yan

Recent advancements in computational pathology have produced patch-level Multi-modal Large Language Models (MLLMs), but these models are limited by their inability to analyze whole slide images (WSIs) comprehensively and their tendency to…

Computer Vision and Pattern Recognition · Computer Science 2025-08-13 Yuci Liang , Xinheng Lyu , Wenting Chen , Meidan Ding , Jipeng Zhang , Xiangjian He , Song Wu , Xiaohan Xing , Sen Yang , Xiyue Wang , Linlin Shen

Recently, histopathology vision-language foundation models (VLMs) have gained popularity due to their enhanced performance and generalizability across different downstream tasks. However, most existing histopathology benchmarks are either…

Image and Video Processing · Electrical Eng. & Systems 2025-03-18 Roba Al Majzoub , Hashmat Malik , Muzammal Naseer , Zaigham Zaheer , Tariq Mahmood , Salman Khan , Fahad Khan

There exist numerous diagnostic tasks in pathology. Conventional computational pathology formulates and tackles them as independent and individual image classification problems, thereby resulting in computational inefficiency and high…

Image and Video Processing · Electrical Eng. & Systems 2024-07-15 Anh Tien Nguyen , Keunho Byeon , Kyungeun Kim , Boram Song , Seoung Wan Chae , Jin Tae Kwak

The rapidly evolving field of digital oncopathology faces significant challenges, including the need to address diverse and complex clinical questions, often involving rare conditions, with limited availability of labeled data. These…

Image and Video Processing · Electrical Eng. & Systems 2024-09-05 Jonathan Zalach , Inbal Gazy , Assaf Avinoam , Ron Sinai , Eran Shmuel , Inbar Gilboa , Christine Swisher , Naim Matasci , Reva Basho , David B. Agus

Liver cancer, especially hepatocellular carcinoma (HCC), imposes a substantial global disease burden. Accurate diagnosis and prognostic assessment directly influence treatment selection and patient survival, and pathological examination…

Computer Vision and Pattern Recognition · Computer Science 2026-04-28 Ying Xiao , Shimiao Tang , Xitong Ling , Weiming Chen , Jun Wang , Jiawen Li , Huaitian Yuan , Jianghui Yang , Bowen Li , Huan Li , Yiting Meng , Tian Guan , Yonghong He , Hongfang Yin

Pathology image segmentation across multiple centers encounters significant challenges due to diverse sources of heterogeneity including imaging modalities, organs, and scanning equipment, whose variability brings representation bias and…

Computer Vision and Pattern Recognition · Computer Science 2025-05-29 Yuan Zhang , Feng Chen , Yaolei Qi , Guanyu Yang , Huazhu Fu

Large language models (LLMs) have shown significant promise across various medical applications, with ophthalmology being a notable area of focus. Many ophthalmic tasks have shown substantial improvement through the integration of LLMs.…

Computation and Language · Computer Science 2025-02-04 Chengfeng Zhou , Ji Wang , Juanjuan Qin , Yining Wang , Ling Sun , Weiwei Dai

Foundation models are reshaping computational pathology by enabling transfer learning, where models pre-trained on vast datasets can be adapted for downstream diagnostic, prognostic, and therapeutic response tasks. Despite these advances,…

Foundation models, often pre-trained with large-scale data, have achieved paramount success in jump-starting various vision and language applications. Recent advances further enable adapting foundation models in downstream tasks efficiently…

Computer Vision and Pattern Recognition · Computer Science 2023-06-19 Dequan Wang , Xiaosong Wang , Lilong Wang , Mengzhang Li , Qian Da , Xiaoqiang Liu , Xiangyu Gao , Jun Shen , Junjun He , Tian Shen , Qi Duan , Jie Zhao , Kang Li , Yu Qiao , Shaoting Zhang

Pathology foundation models (PFMs) have enabled robust generalization in computational pathology through large-scale datasets and expansive architectures, but their substantial computational cost, particularly for gigapixel whole slide…

Breast cancer is one of the leading causes of death among women worldwide. We introduce Mammo-FM, the first foundation model specifically for mammography, pretrained on the largest and most diverse dataset to date - 140,677 patients…

Large pretrained transformers are increasingly being developed as generalised foundation models which can underpin powerful task-specific artificial intelligence models. Histopathology foundation models show great promise across many tasks,…

Image and Video Processing · Electrical Eng. & Systems 2024-09-10 Jack Breen , Katie Allen , Kieran Zucker , Lucy Godson , Nicolas M. Orsi , Nishant Ravikumar

As natural image understanding moves towards the pretrain-finetune era, research in pathology imaging is concurrently evolving. Despite the predominant focus on pretraining pathological foundation models, how to adapt foundation models to…

Computer Vision and Pattern Recognition · Computer Science 2024-07-16 Jiaxuan Lu , Fang Yan , Xiaofan Zhang , Yue Gao , Shaoting Zhang

Machine learning on graphs has made substantial progress across domains such as molecular property prediction and chip design. Yet benchmarking practices remain fragmented, often relying on narrow, task-specific datasets and inconsistent…

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