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Neural models that do not rely on pre-training have excelled in the keyphrase generation task with large annotated datasets. Meanwhile, new approaches have incorporated pre-trained language models (PLMs) for their data efficiency. However,…

Computation and Language · Computer Science 2024-02-26 Di Wu , Wasi Uddin Ahmad , Kai-Wei Chang

Multi-modality pre-training paradigm that aligns protein sequences and biological descriptions has learned general protein representations and achieved promising performance in various downstream applications. However, these works were…

Machine Learning · Computer Science 2024-12-31 Hanjing Zhou , Mingze Yin , Wei Wu , Mingyang Li , Kun Fu , Jintai Chen , Jian Wu , Zheng Wang

Phenotype-driven gene prioritization is a critical process in the diagnosis of rare genetic disorders for identifying and ranking potential disease-causing genes based on observed physical traits or phenotypes. While traditional approaches…

Quantitative Methods · Quantitative Biology 2024-04-04 Junyoung Kim , Jingye Yang , Kai Wang , Chunhua Weng , Cong Liu

Pre-trained language models (PLMs) have shown remarkable successes in acquiring a wide range of linguistic knowledge, relying solely on self-supervised training on text streams. Nevertheless, the effectiveness of this language-agnostic…

Computation and Language · Computer Science 2023-11-02 Eylon Gueta , Omer Goldman , Reut Tsarfaty

The reusability of state-of-the-art Pre-trained Language Models (PLMs) is often limited by their generalization problem, where their performance drastically decreases when evaluated on examples that differ from the training dataset, known…

Computation and Language · Computer Science 2023-08-09 Somayeh Ghanbarzadeh , Hamid Palangi , Yan Huang , Radames Cruz Moreno , Hamed Khanpour

Process mining is increasingly using textual information associated with events to tackle tasks such as anomaly detection and process discovery. Such semantics-aware process mining focuses on what behavior should be possible in a process…

Computation and Language · Computer Science 2025-08-25 Vira Pyrih , Adrian Rebmann , Han van der Aa

While pre-trained language models (LMs) have brought great improvements in many NLP tasks, there is increasing attention to explore capabilities of LMs and interpret their predictions. However, existing works usually focus only on a certain…

Computation and Language · Computer Science 2022-07-29 Yaozong Shen , Lijie Wang , Ying Chen , Xinyan Xiao , Jing Liu , Hua Wu

We present MeshLLM, a novel framework that leverages large language models (LLMs) to understand and generate text-serialized 3D meshes. Our approach addresses key limitations in existing methods, including the limited dataset scale when…

One of the challenges with finetuning pretrained language models (PLMs) is that their tokenizer is optimized for the language(s) it was pretrained on, but brittle when it comes to previously unseen variations in the data. This can for…

Computation and Language · Computer Science 2023-04-21 Verena Blaschke , Hinrich Schütze , Barbara Plank

Predicting molecular properties is a critical component of drug discovery. Recent advances in deep learning, particularly Graph Neural Networks (GNNs), have enabled end-to-end learning from molecular structures, reducing reliance on manual…

Computation and Language · Computer Science 2025-09-26 Peng Zhou , Lai Hou Tim , Zhixiang Cheng , Kun Xie , Chaoyi Li , Wei Liu , Xiangxiang Zeng

In the rapidly advancing field of Large Language Models (LLMs), effectively leveraging existing datasets during fine-tuning to maximize the model's potential is of paramount importance. This paper introduces P3, an adaptive framework aimed…

Computation and Language · Computer Science 2024-10-21 Yingxuan Yang , Huayi Wang , Muning Wen , Xiaoyun Mo , Qiuying Peng , Jun Wang , Weinan Zhang

Pre-trained language models have recently emerged as a powerful tool for fine-tuning a variety of language tasks. Ideally, when models are pre-trained on large amount of data, they are expected to gain implicit knowledge. In this paper, we…

Computation and Language · Computer Science 2023-06-22 Mohamad Ballout , Ulf Krumnack , Gunther Heidemann , Kai-Uwe Kühnberger

Recent advances in protein language models (PLMs) have demonstrated remarkable capabilities in understanding protein sequences. However, the extent to which different model architectures capture antibody-specific biological properties…

Machine Learning · Computer Science 2025-12-11 Mengren , Liu , Yixiang Zhang , Yiming , Zhang

We introduce Concept Bottleneck Protein Language Models (CB-pLM), a generative masked language model with a layer where each neuron corresponds to an interpretable concept. Our architecture offers three key benefits: i) Control: We can…

Pre-trained language model (PTM) has been shown to yield powerful text representations for dense passage retrieval task. The Masked Language Modeling (MLM) is a major sub-task of the pre-training process. However, we found that the…

Computation and Language · Computer Science 2022-10-28 Dingkun Long , Yanzhao Zhang , Guangwei Xu , Pengjun Xie

Pre-trained language models learn informative word representations on a large-scale text corpus through self-supervised learning, which has achieved promising performance in fields of natural language processing (NLP) after fine-tuning.…

Computation and Language · Computer Science 2023-10-31 Jian Yang , Xinyu Hu , Gang Xiao , Yulong Shen

Language models (LMs) are pre-trained on raw text datasets to generate text sequences token-by-token. While this approach facilitates the learning of world knowledge and reasoning, it does not explicitly optimize for linguistic competence.…

Computation and Language · Computer Science 2026-04-17 Atsuki Yamaguchi , Maggie Mi , Nikolaos Aletras

Less than 1% of protein sequences are structurally and functionally annotated. Natural Language Processing (NLP) community has recently embraced self-supervised learning as a powerful approach to learn representations from unlabeled text,…

Biomolecules · Quantitative Biology 2020-12-08 Modestas Filipavicius , Matteo Manica , Joris Cadow , Maria Rodriguez Martinez

Protein language models (pLMs) have shown strong potential for zero-shot prediction of missense variant effects, yet systematic benchmarking on viral proteins remains limited, a critical gap given the need for proactive tools that can…

Quantitative Methods · Quantitative Biology 2026-05-20 Yichen Zhou , Jonathan Golob , Amir Karimi , Stefan Bauer , Patrick Schwab

Language is essentially a complex, intricate system of human expressions governed by grammatical rules. It poses a significant challenge to develop capable AI algorithms for comprehending and grasping a language. As a major approach,…

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