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The growing disparity between the exponential scaling of computational resources and the finite growth of high-quality text data now constrains conventional scaling approaches for large language models (LLMs). To address this challenge, we…

Multimodal Large Language Models (MLLMs) have achieved remarkable progress in domains such as visual understanding and mathematical reasoning. However, their application in the medical domain is constrained by two key challenges: (1)…

Computation and Language · Computer Science 2025-10-09 Zeyu Liu , Zhitian Hou , Guanghao Zhu , Zhijie Sang , Congkai Xie , Hongxia Yang

Large Language Models (LLMs) have emerged as transformative tools in the healthcare sector, demonstrating remarkable capabilities in natural language understanding and generation. However, their proficiency in numerical reasoning,…

Artificial Intelligence · Computer Science 2025-01-27 Arjun R. Malghan

The proliferation of Large Language Models (LLMs) in medicine has enabled impressive capabilities, yet a critical gap remains in their ability to perform systematic, transparent, and verifiable reasoning, a cornerstone of clinical practice.…

Computation and Language · Computer Science 2025-08-04 Wenxuan Wang , Zizhan Ma , Meidan Ding , Shiyi Zheng , Shengyuan Liu , Jie Liu , Jiaming Ji , Wenting Chen , Xiang Li , Linlin Shen , Yixuan Yuan

In medical scenarios, effectively retrieving external knowledge and leveraging it for rigorous logical reasoning is of significant importance. Despite their potential, existing work has predominantly focused on enhancing either retrieval or…

Computation and Language · Computer Science 2026-01-21 Keer Lu , Zheng Liang , Youquan Li , Jiejun Tan , Xili Wang , Da Pan , Shusen Zhang , Guosheng Dong , Bin Cui , Yunhuai Liu , Wentao Zhang

As large language models (LLMs) become increasingly integrated into clinical decision-making, ensuring transparent and trustworthy reasoning is essential. However, existing evaluation strategies of LLMs' medical reasoning capability either…

Large language models (LLMs) hold transformative potential for medical decision support yet their application in psychiatry remains constrained by hallucinations and superficial reasoning. This limitation is particularly acute in…

In recent years, training methods centered on Reinforcement Learning (RL) have markedly enhanced the reasoning and alignment performance of Large Language Models (LLMs), particularly in understanding human intents, following user…

Computation and Language · Computer Science 2025-09-23 Keliang Liu , Dingkang Yang , Ziyun Qian , Weijie Yin , Yuchi Wang , Hongsheng Li , Jun Liu , Peng Zhai , Yang Liu , Lihua Zhang

Large Language Models (LLMs) have been shown to encode clinical knowledge. Many evaluations, however, rely on structured question-answer benchmarks, overlooking critical challenges of interpreting and reasoning about unstructured clinical…

Computation and Language · Computer Science 2026-04-01 Meghal Dani , Muthu Jeyanthi Prakash , Filip Rosa , Zeynep Akata , Stefanie Liebe

Recent advances in fine-tuning large language models (LLMs) with reinforcement learning (RL) have shown promising improvements in complex reasoning tasks, particularly when paired with chain-of-thought (CoT) prompting. However, these…

Machine Learning · Computer Science 2025-04-04 Hung Le , Dai Do , Dung Nguyen , Svetha Venkatesh

Large language models (LLMs) have achieved strong performance on medical exam-style tasks, motivating growing interest in their deployment in real-world clinical settings. However, clinical decision-making is inherently safety-critical,…

Computation and Language · Computer Science 2026-04-13 Xiaohan Ren , Chenxiao Fan , Wenyin Ma , Hongliang He , Chongming Gao , Xiaoyan Zhao , Fuli Feng

Reinforcement learning (RL) has become a key technique for enhancing the reasoning abilities of large language models (LLMs), with policy-gradient algorithms dominating the post-training stage because of their efficiency and effectiveness.…

Artificial Intelligence · Computer Science 2025-08-08 Chang Tian , Matthew B. Blaschko , Mingzhe Xing , Xiuxing Li , Yinliang Yue , Marie-Francine Moens

Physicians considering clinical trials for their patients are met with the laborious process of checking many text based eligibility criteria. Large Language Models (LLMs) have shown to perform well for clinical information extraction and…

Machine Learning · Computer Science 2023-06-30 Danny M. den Hamer , Perry Schoor , Tobias B. Polak , Daniel Kapitan

The growing integration of vision-language models (VLMs) in medical applications offers promising support for diagnostic reasoning. However, current medical VLMs often face limitations in generalization, transparency, and computational…

Computer Vision and Pattern Recognition · Computer Science 2025-06-17 Tan-Hanh Pham , Chris Ngo

Recent large reasoning models (LRMs) have demonstrated strong reasoning capabilities through reinforcement learning (RL). These improvements have primarily been observed within the short-context reasoning tasks. In contrast, extending LRMs…

Computation and Language · Computer Science 2025-05-28 Fanqi Wan , Weizhou Shen , Shengyi Liao , Yingcheng Shi , Chenliang Li , Ziyi Yang , Ji Zhang , Fei Huang , Jingren Zhou , Ming Yan

Recent advancements in large language models (LLMs) have shown promise in medical applications such as disease diagnosis and treatment planning. However, most existing medical LLMs struggle with the deep reasoning required for complex…

Computation and Language · Computer Science 2025-07-31 Hongzhou Yu , Tianhao Cheng , Yingwen Wang , Wen He , Qing Wang , Ying Cheng , Yuejie Zhang , Rui Feng , Xiaobo Zhang

Open-source, multilingual medical large language models (LLMs) have the potential to serve linguistically diverse populations across different regions. Adapting generic LLMs for healthcare often requires continual pretraining, but this…

Computation and Language · Computer Science 2024-09-10 Meng Zhou , Surajsinh Parmar , Anubhav Bhatti

Large language models (LLMs) face significant challenges in specialized biomedical tasks due to the inherent complexity of medical reasoning and the sensitive nature of clinical data. Existing LLMs often struggle with intricate medical…

Computation and Language · Computer Science 2026-05-12 Zongxian Yang , Jiayu Qian , Kay Chen Tan , Hau-San Wong , Yulong Chen , Haoyu Zhang , Zhi-An Huang

Recent advancements in reasoning-enhanced large language models (LLMs), such as DeepSeek-R1 and OpenAI-o3, have demonstrated significant progress. However, their application in professional medical contexts remains underexplored,…

Computation and Language · Computer Science 2025-03-11 Pengcheng Qiu , Chaoyi Wu , Shuyu Liu , Weike Zhao , Zhuoxia Chen , Hongfei Gu , Chuanjin Peng , Ya Zhang , Yanfeng Wang , Weidi Xie

Large Language Models (LLMs) have achieved remarkable success through imitation learning on vast text corpora, but this paradigm creates a training-generation gap and limits robust reasoning. Reinforcement learning (RL) offers a more…

Computation and Language · Computer Science 2026-04-13 Zhepeng Cen , Haolin Chen , Shiyu Wang , Zuxin Liu , Zhiwei Liu , Jielin Qiu , Ding Zhao , Silvio Savarese , Caiming Xiong , Huan Wang , Weiran Yao
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