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Large language models perform well on many medical QA benchmarks, but real clinical reasoning often requires integrating evidence across multiple images rather than interpreting a single view. We introduce MedThinkVQA, an expert-annotated…

Computer Vision and Pattern Recognition · Computer Science 2026-05-05 Zonghai Yao , Benlu Wang , Yifan Zhang , Junda Wang , Iris Xia , Zhipeng Tang , Shuo Han , Feiyun Ouyang , Zhichao Yang , Arman Cohan , Hong Yu

Medical Image Quality Assessment (IQA) serves as the first-mile safety gate for clinical AI, yet existing approaches remain constrained by scalar, score-based metrics and fail to reflect the descriptive, human-like reasoning process central…

We introduce MedXpertQA, a highly challenging and comprehensive benchmark to evaluate expert-level medical knowledge and advanced reasoning. MedXpertQA includes 4,460 questions spanning 17 specialties and 11 body systems. It includes two…

Artificial Intelligence · Computer Science 2025-06-09 Yuxin Zuo , Shang Qu , Yifei Li , Zhangren Chen , Xuekai Zhu , Ermo Hua , Kaiyan Zhang , Ning Ding , Bowen Zhou

This paper introduces MedExQA, a novel benchmark in medical question-answering, to evaluate large language models' (LLMs) understanding of medical knowledge through explanations. By constructing datasets across five distinct medical…

Computation and Language · Computer Science 2024-07-04 Yunsoo Kim , Jinge Wu , Yusuf Abdulle , Honghan Wu

Multimodal/vision language models (VLMs) are increasingly being deployed in healthcare settings worldwide, necessitating robust benchmarks to ensure their safety, efficacy, and fairness. Multiple-choice question and answer (QA) datasets…

Explainability is critical for the clinical adoption of medical visual question answering (VQA) systems, as physicians require transparent reasoning to trust AI-generated diagnoses. We present MedXplain-VQA, a comprehensive framework…

Computer Vision and Pattern Recognition · Computer Science 2025-10-28 Hai-Dang Nguyen , Minh-Anh Dang , Minh-Tan Le , Minh-Tuan Le

Large language models (LLMs) are increasingly envisioned as decision-support tools in clinical practice, yet safe clinical reasoning demands integrating heterogeneous knowledge bases -- trials, primary studies, regulatory documents, and…

Computation and Language · Computer Science 2025-05-22 Shan Chen , Pedro Moreira , Yuxin Xiao , Sam Schmidgall , Jeremy Warner , Hugo Aerts , Thomas Hartvigsen , Jack Gallifant , Danielle S. Bitterman

Brain imaging analysis is crucial for diagnosing and treating brain disorders, and multimodal large language models (MLLMs) are increasingly supporting it. However, current brain imaging visual question-answering (VQA) benchmarks either…

Computer Vision and Pattern Recognition · Computer Science 2025-12-29 Zhihao Peng , Cheng Wang , Shengyuan Liu , Zhiying Liang , Zanting Ye , Minjie Ju , PeterYM Woo , Yixuan Yuan

Scientific research demands sophisticated reasoning over multimodal data, a challenge especially prevalent in biology. Despite recent advances in multimodal large language models (MLLMs) for AI-assisted research, existing multimodal…

Multimodal Large Language Models (MLLMs) have demonstrated impressive abilities across various tasks, including visual question answering and chart comprehension, yet existing benchmarks for chart-related tasks fall short in capturing the…

Computation and Language · Computer Science 2025-02-11 Zifeng Zhu , Mengzhao Jia , Zhihan Zhang , Lang Li , Meng Jiang

Visual grounding is essential for precise perception and reasoning in multimodal large language models (MLLMs), especially in medical imaging domains. While existing medical visual grounding benchmarks primarily focus on single-image…

Computer Vision and Pattern Recognition · Computer Science 2025-05-20 Jingkun Yue , Siqi Zhang , Zinan Jia , Huihuan Xu , Zongbo Han , Xiaohong Liu , Guangyu Wang

MLLMs MLLMs are beginning to appear in clinical workflows, but their ability to perform complex medical reasoning remains unclear. We present Med-CMR, a fine-grained Medical Complex Multimodal Reasoning benchmark. Med-CMR distinguishes from…

Spatial reasoning and visual grounding are core capabilities for vision-language models (VLMs), yet most medical VLMs produce predictions without transparent reasoning or spatial evidence. Existing benchmarks also evaluate VLMs on isolated…

Computer Vision and Pattern Recognition · Computer Science 2026-04-20 Lama Moukheiber , Caleb M. Yeung , Haotian Xue , Alec Helbling , Zelin Zhao , Yongxin Chen

Vision-Language Models (VLMs) have demonstrated remarkable capabilities in interpreting visual layouts and text. However, a significant challenge remains in their ability to interpret robustly and reason over multi-tabular data presented as…

Computer Vision and Pattern Recognition · Computer Science 2025-06-16 Anshul Singh , Chris Biemann , Jan Strich

Multimodal Large Language Models (MLLMs) have tremendous potential to improve the accuracy, availability, and cost-effectiveness of healthcare by providing automated solutions or serving as aids to medical professionals. Despite promising…

Computer Vision and Pattern Recognition · Computer Science 2025-05-22 Mohammad Shahab Sepehri , Zalan Fabian , Maryam Soltanolkotabi , Mahdi Soltanolkotabi

Large Vision-Language Models (LVLMs) have demonstrated remarkable capabilities in various multimodal tasks. However, their potential in the medical domain remains largely unexplored. A significant challenge arises from the scarcity of…

Image and Video Processing · Electrical Eng. & Systems 2024-04-23 Yutao Hu , Tianbin Li , Quanfeng Lu , Wenqi Shao , Junjun He , Yu Qiao , Ping Luo

Vision-language models have demonstrated impressive capabilities in general medical visual question answering, yet due to limited interpretability, it remains unclear whether their predictions reflect evidence-grounded clinical reasoning or…

Computer Vision and Pattern Recognition · Computer Science 2026-05-26 Wen Ma , Fucheng Niu , Zhiting Fan , Zikai Xiao , Jiaxiang Liu , Zuozhu Liu

Medical Visual Question Answering (MedVQA) presents a significant opportunity to enhance diagnostic accuracy and healthcare delivery by leveraging artificial intelligence to interpret and answer questions based on medical images. In this…

Computer Vision and Pattern Recognition · Computer Science 2024-09-10 Xiaoman Zhang , Chaoyi Wu , Ziheng Zhao , Weixiong Lin , Ya Zhang , Yanfeng Wang , Weidi Xie

Large language models (LLMs) show promise for clinical use. They are often evaluated using datasets such as MedQA. However, Many medical datasets, such as MedQA, rely on simplified Question-Answering (Q\A) that underrepresents real-world…

Computation and Language · Computer Science 2025-10-24 Yunpeng Xiao , Carl Yang , Mark Mai , Xiao Hu , Kai Shu

The potential of Multimodal Large Language Models (MLLMs) in domain of medical imaging raise the demands of systematic and rigorous evaluation frameworks that are aligned with the real-world medical imaging practice. Existing practices that…

Computation and Language · Computer Science 2026-04-16 Zhijie Bao , Fangke Chen , Licheng Bao , Chenhui Zhang , Wei Chen , Jiajie Peng , Zhongyu Wei
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