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Multimodal large language models (MLLMs) have advanced clinical tasks for common conditions, but their performance on rare diseases remains largely untested. In rare-disease scenarios, clinicians often lack prior clinical knowledge, forcing…

Computer Vision and Pattern Recognition · Computer Science 2026-05-14 Junzhi Ning , Jiashi Lin , Yingying Fang , Wei Li , Jiyao Liu , Cheng Tang , Chenglong Ma , Wenhao Tang , Tianbin Li , Ziyan Huang , Guang Yang , Junjun He

Recent advancements in Large Language Models (LLMs) and Large Multi-modal Models (LMMs) have shown potential in various medical applications, such as Intelligent Medical Diagnosis. Although impressive results have been achieved, we find…

Visual reasoning over structured data such as tables is a critical capability for modern vision-language models (VLMs), yet current benchmarks remain limited in scale, diversity, or reasoning depth, especially when it comes to rendered…

Computer Vision and Pattern Recognition · Computer Science 2026-04-22 Boammani Aser Lompo , Marc Haraoui

Multimodal language models (MLMs) show promise for clinical decision support and diagnostic reasoning, raising the prospect of end-to-end automated medical image interpretation. However, clinicians are highly selective in adopting AI tools;…

Artificial Intelligence · Computer Science 2025-08-06 Mahtab Bigverdi , Wisdom Ikezogwo , Kevin Zhang , Hyewon Jeong , Mingyu Lu , Sungjae Cho , Linda Shapiro , Ranjay Krishna

Vision-Language Models (VLMs) have demonstrated remarkable progress in multimodal understanding, yet their capabilities for scientific reasoning remain inadequately assessed. Current multimodal benchmarks predominantly evaluate generic…

Computer Vision and Pattern Recognition · Computer Science 2025-06-18 Ai Jian , Weijie Qiu , Xiaokun Wang , Peiyu Wang , Yunzhuo Hao , Jiangbo Pei , Yichen Wei , Yi Peng , Xuchen Song

Rapid advances in medical imaging technology underscore the critical need for precise and automated image quality assessment (IQA) to ensure diagnostic accuracy. Existing medical IQA methods, however, struggle to generalize across diverse…

Computer Vision and Pattern Recognition · Computer Science 2025-07-28 Siyi Xun , Yue Sun , Jingkun Chen , Zitong Yu , Tong Tong , Xiaohong Liu , Mingxiang Wu , Tao Tan

Large language models (LLMs) have excelled across domains, also delivering notable performance on the medical evaluation benchmarks, such as MedQA. However, there still exists a significant gap between the reported performance and the…

Computation and Language · Computer Science 2024-06-06 Yuxuan Zhou , Xien Liu , Chen Ning , Ji Wu

Medical vision-language models (VLMs) and AI agents have made significant progress in learning to analyze and reason about clinical images. However, existing medical visual question answering (VQA) benchmarks collapse model capabilities…

Computer Vision and Pattern Recognition · Computer Science 2026-05-12 Yixiong Chen , Wenjie Xiao , Pedro R. A. S. Bassi , Boyan Wang , Liang He , Xinze Zhou , Sezgin Er , Ibrahim Ethem Hamamci , Zongwei Zhou , Alan Yuille

Recent advances in vision-language models (VLMs) have achieved remarkable performance on standard medical benchmarks, yet their true clinical reasoning ability remains unclear. Existing datasets predominantly emphasize classification…

Computer Vision and Pattern Recognition · Computer Science 2026-05-20 Miao Jing , Mengting Jia , Junling Lin , Zhongxia Shen , Huan Gao , Mingkun Xu , Shangyang Li

Multimodal Large Language Models are increasingly applied to biomedical imaging, yet scientific reasoning for microscopy remains limited by the scarcity of large-scale, high-quality training data. We introduce MicroVQA++, a three-stage,…

Computer Vision and Pattern Recognition · Computer Science 2025-11-17 Manyu Li , Ruian He , Chenxi Ma , Weimin Tan , Bo Yan

Medical Large Multi-modal Models (LMMs) have demonstrated remarkable capabilities in medical data interpretation. However, these models frequently generate hallucinations contradicting source evidence, particularly due to inadequate…

Establishing a clear link between model predictions and the visual evidence that supports them is critical for transparency and reliability in multimodal reasoning, yet current multimodal large language model (MLLM) evaluations do not…

Computer Vision and Pattern Recognition · Computer Science 2026-05-21 Mozhgan Nasr Azadani , Yimu Wang , Yongpeng Zhu , Lihong Chen , Milan Ganai , Sean Sedwards , Marco Pavone , Krzysztof Czarnecki

Large language models (LLMs) have demonstrated impressive capabilities in natural language understanding and generation, but the quality bar for medical and clinical applications is high. Today, attempts to assess models' clinical knowledge…

Large vision-language models (VLMs) demonstrate strong performance in medical image understanding, but frequently generate clinically plausible yet incorrect statements, raising significant safety concerns. Existing medical hallucination…

With the rapid growth of large language models (LLMs) and vision-language models (VLMs) in medicine, simply integrating clinical text and medical imaging does not guarantee reliable reasoning. Existing multimodal models often produce…

Artificial Intelligence · Computer Science 2025-12-29 Zelin Zang , Wenyi Gu , Siqi Ma , Dan Yang , Yue Shen , Zhu Zhang , Guohui Fan , Wing-Kuen Ling , Fuji Yang

Medical Visual Question Answering (MedVQA), which offers language responses to image-based medical inquiries, represents a challenging task and significant advancement in healthcare. It assists medical experts to swiftly interpret medical…

Computer Vision and Pattern Recognition · Computer Science 2024-10-08 Xiaotang Gai , Chenyi Zhou , Jiaxiang Liu , Yang Feng , Jian Wu , Zuozhu Liu

Background: The rapid integration of foundation models into clinical practice and public health necessitates a rigorous evaluation of their true clinical reasoning capabilities beyond narrow examination success. Current benchmarks,…

Computer Vision and Pattern Recognition · Computer Science 2025-12-30 Dingyu Wang , Zimu Yuan , Jiajun Liu , Shanggui Liu , Nan Zhou , Tianxing Xu , Di Huang , Dong Jiang

With the increasing integration of Multimodal Large Language Models (MLLMs) into the medical field, comprehensive evaluation of their performance in various medical domains becomes critical. However, existing benchmarks primarily assess…

Computer Vision and Pattern Recognition · Computer Science 2025-10-15 Chenghanyu Zhang , Zekun Li , Peipei Li , Xing Cui , Shuhan Xia , Weixiang Yan , Yiqiao Zhang , Qianyu Zhuang

Clinical reasoning in medicine is a hypothesis-driven process where physicians refine diagnoses from limited information through targeted history, physical examination, and diagnostic investigations. In contrast, current medical benchmarks…

Machine Learning · Computer Science 2025-10-14 Christopher Chiu , Silviu Pitis , Mihaela van der Schaar

Medical Vision-Language Models (Med-VLMs) have achieved expert-level proficiency in interpreting diagnostic imaging. However, current models are predominantly trained on professional literature, limiting their ability to communicate…

Computation and Language · Computer Science 2026-04-08 Han Jang , Junhyeok Lee , Heeseong Eum , Kyu Sung Choi